(data stored in SCRATCH zone)

SWISSPROT: E6UYX7_VARPE

ID   E6UYX7_VARPE            Unreviewed;       428 AA.
AC   E6UYX7;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   08-MAY-2019, entry version 49.
DE   RecName: Full=3-hydroxy-3-methylglutaryl coenzyme A reductase {ECO:0000256|RuleBase:RU361219};
DE            Short=HMG-CoA reductase {ECO:0000256|RuleBase:RU361219};
DE            EC=1.1.1.88 {ECO:0000256|RuleBase:RU361219};
GN   OrderedLocusNames=Varpa_0083 {ECO:0000313|EMBL:ADU34306.1};
OS   Variovorax paradoxus (strain EPS).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=595537 {ECO:0000313|EMBL:ADU34306.1, ECO:0000313|Proteomes:UP000008917};
RN   [1] {ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|Proteomes:UP000008917};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
RA   Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Orwin P.,
RA   Han J.-I.G., Woyke T.;
RT   "Complete sequence of Variovorax paradoxus EPS.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADU34306.1, ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|EMBL:ADU34306.1,
RC   ECO:0000313|Proteomes:UP000008917};
RX   PubMed=24158554;
RA   Han J.I., Spain J.C., Leadbetter J.R., Ovchinnikova G., Goodwin L.A.,
RA   Han C.S., Woyke T., Davenport K.W., Orwin P.M.;
RT   "Genome of the Root-Associated Plant Growth-Promoting Bacterium
RT   Variovorax paradoxus Strain EPS.";
RL   Genome Announc. 1:e00843-13(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-mevalonate + CoA + 2 NAD(+) = (3S)-hydroxy-3-
CC         methylglutaryl-CoA + 2 H(+) + 2 NADH; Xref=Rhea:RHEA:14833,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:36464, ChEBI:CHEBI:43074,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945;
CC         EC=1.1.1.88; Evidence={ECO:0000256|RuleBase:RU361219};
CC   -!- PATHWAY: Metabolic intermediate metabolism; (R)-mevalonate
CC       degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-
CC       mevalonate: step 1/1. {ECO:0000256|RuleBase:RU361219}.
CC   -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC       {ECO:0000256|RuleBase:RU361219}.
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DR   EMBL; CP002417; ADU34306.1; -; Genomic_DNA.
DR   RefSeq; WP_013538553.1; NC_014931.1.
DR   STRING; 595537.Varpa_0083; -.
DR   EnsemblBacteria; ADU34306; ADU34306; Varpa_0083.
DR   GeneID; 29717487; -.
DR   KEGG; vpe:Varpa_0083; -.
DR   eggNOG; ENOG4107EEU; Bacteria.
DR   eggNOG; COG1257; LUCA.
DR   HOGENOM; HOG000266314; -.
DR   KO; K00054; -.
DR   OMA; ATGNDFR; -.
DR   OrthoDB; 617929at2; -.
DR   BioCyc; VPAR595537:G1GQO-81-MONOMER; -.
DR   UniPathway; UPA00257; UER00367.
DR   Proteomes; UP000008917; Chromosome.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.
DR   GO; GO:0042282; F:hydroxymethylglutaryl-CoA reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR   CDD; cd00644; HMG-CoA_reductase_classII; 1.
DR   Gene3D; 3.30.70.420; -; 1.
DR   Gene3D; 3.90.770.10; -; 1.
DR   InterPro; IPR002202; HMG_CoA_Rdtase.
DR   InterPro; IPR004553; HMG_CoA_Rdtase_bac-typ.
DR   InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR   InterPro; IPR023076; HMG_CoA_Rdtase_CS.
DR   InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR   InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR   PANTHER; PTHR10572; PTHR10572; 1.
DR   PANTHER; PTHR10572:SF13; PTHR10572:SF13; 1.
DR   Pfam; PF00368; HMG-CoA_red; 1.
DR   PRINTS; PR00071; HMGCOARDTASE.
DR   SUPFAM; SSF55035; SSF55035; 1.
DR   SUPFAM; SSF56542; SSF56542; 1.
DR   TIGRFAMs; TIGR00532; HMG_CoA_R_NAD; 1.
DR   PROSITE; PS00066; HMG_COA_REDUCTASE_1; 1.
DR   PROSITE; PS00318; HMG_COA_REDUCTASE_2; 1.
DR   PROSITE; PS01192; HMG_COA_REDUCTASE_3; 1.
DR   PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE   3: Inferred from homology;
DR   PRODOM; E6UYX7.
DR   SWISS-2DPAGE; E6UYX7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008917};
KW   NAD {ECO:0000256|RuleBase:RU361219};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU361219,
KW   ECO:0000313|EMBL:ADU34306.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008917}.
SQ   SEQUENCE   428 AA;  45123 MW;  FE667FF42B505EE8 CRC64;
     MVADSRIPNF RALTPAQRFA HIAKAASLTD DEVALLAQPG ALSVDRANGM VENVIGTFEL
     PLGVAGNFTV NGRDYLVPMA VEEPSVVAAA SFMAKLAREG GGFEASSTGP LMRAQVQVIG
     ITDPYGARLA LLRAREEILA VANSRDKVLI DLGGGCRDIE VHVFGDTPRG AMVVMHLIVD
     VRDAMGANTV NTMAEAVSPL VEKLTGGTVR LRILSNLADL RLARARVRLA PAVLATRERS
     GEEVVEGVID AYTFAAIDPY RAATHNKGIM NGVDPVIVAT GNDWRAVEAG AHAYACRSGR
     YTSLTTWEKD TTGALVGTIE MPMPVGLVGG ATKTHPLARL ALKILDVKSA QELGEVAVAV
     GLAQNLGALR ALATEGIQRG HMALHARNIA LVAGATGDEI DSIAKQMAAE HDVRTDRAVA
     LLEALRKK
//

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