SWISSPROT: E6V195_VARPE

ID   E6V195_VARPE            Unreviewed;       325 AA.
AC   E6V195;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   08-MAY-2019, entry version 42.
DE   SubName: Full=2-dehydropantoate 2-reductase {ECO:0000313|EMBL:ADU34459.1};
DE            EC=1.1.1.169 {ECO:0000313|EMBL:ADU34459.1};
GN   OrderedLocusNames=Varpa_0237 {ECO:0000313|EMBL:ADU34459.1};
OS   Variovorax paradoxus (strain EPS).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=595537 {ECO:0000313|EMBL:ADU34459.1, ECO:0000313|Proteomes:UP000008917};
RN   [1] {ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|Proteomes:UP000008917};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
RA   Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Orwin P.,
RA   Han J.-I.G., Woyke T.;
RT   "Complete sequence of Variovorax paradoxus EPS.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADU34459.1, ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|EMBL:ADU34459.1,
RC   ECO:0000313|Proteomes:UP000008917};
RX   PubMed=24158554;
RA   Han J.I., Spain J.C., Leadbetter J.R., Ovchinnikova G., Goodwin L.A.,
RA   Han C.S., Woyke T., Davenport K.W., Orwin P.M.;
RT   "Genome of the Root-Associated Plant Growth-Promoting Bacterium
RT   Variovorax paradoxus Strain EPS.";
RL   Genome Announc. 1:e00843-13(2013).
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DR   EMBL; CP002417; ADU34459.1; -; Genomic_DNA.
DR   RefSeq; WP_013538705.1; NC_014931.1.
DR   STRING; 595537.Varpa_0237; -.
DR   EnsemblBacteria; ADU34459; ADU34459; Varpa_0237.
DR   GeneID; 29718476; -.
DR   KEGG; vpe:Varpa_0237; -.
DR   eggNOG; ENOG41084M5; Bacteria.
DR   eggNOG; COG1893; LUCA.
DR   HOGENOM; HOG000050222; -.
DR   KO; K00077; -.
DR   OMA; RHHQGNG; -.
DR   OrthoDB; 427052at2; -.
DR   BioCyc; VPAR595537:G1GQO-239-MONOMER; -.
DR   Proteomes; UP000008917; Chromosome.
DR   GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR013752; KPA_reductase.
DR   InterPro; IPR013332; KPR_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF02558; ApbA; 1.
DR   Pfam; PF08546; ApbA_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   4: Predicted;
DR   PRODOM; E6V195.
DR   SWISS-2DPAGE; E6V195.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008917};
KW   Oxidoreductase {ECO:0000313|EMBL:ADU34459.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008917}.
FT   DOMAIN        3    167       ApbA. {ECO:0000259|Pfam:PF02558}.
FT   DOMAIN      198    317       ApbA_C. {ECO:0000259|Pfam:PF08546}.
SQ   SEQUENCE   325 AA;  34234 MW;  AE9E047CB2293543 CRC64;
     MKICIYGAGA IGGWIGAGLA QAGERLNVVA RGATLDVLQR DGLSLMRADV RTRVPVNAVA
     DPDALGVQDL VVIAVKAPAL AAVAERIGPL IGPDTIVLVA MNGVPWWFLE GGFGGEITGR
     RLAAVDPDGA IAKAIPARNV IGCVVHASCS LDGPGVVRHH FGNGLIVGEP SGEATPRVQA
     LVELLTRAGI NTTLSPQIQK DVWFKLWGNM TVNPISALTG ATTDLIMGDD YVRGFISAVM
     LEAKEIGRRI GIEITQSPED RHEVTKKLGA FKTSMLQDVE AGRSVELDAL VTVVRELGEL
     TGVATPFTDA LLGLARLRTR QLGLY
//