SWISSPROT: E6V5E6_VARPE

ID   E6V5E6_VARPE            Unreviewed;       331 AA.
AC   E6V5E6;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   08-MAY-2019, entry version 48.
DE   RecName: Full=Non-homologous end joining protein Ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN   Name=ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN   OrderedLocusNames=Varpa_0531 {ECO:0000313|EMBL:ADU34752.1};
OS   Variovorax paradoxus (strain EPS).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=595537 {ECO:0000313|EMBL:ADU34752.1, ECO:0000313|Proteomes:UP000008917};
RN   [1] {ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|Proteomes:UP000008917};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
RA   Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Orwin P.,
RA   Han J.-I.G., Woyke T.;
RT   "Complete sequence of Variovorax paradoxus EPS.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADU34752.1, ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|EMBL:ADU34752.1,
RC   ECO:0000313|Proteomes:UP000008917};
RX   PubMed=24158554;
RA   Han J.I., Spain J.C., Leadbetter J.R., Ovchinnikova G., Goodwin L.A.,
RA   Han C.S., Woyke T., Davenport K.W., Orwin P.M.;
RT   "Genome of the Root-Associated Plant Growth-Promoting Bacterium
RT   Variovorax paradoxus Strain EPS.";
RL   Genome Announc. 1:e00843-13(2013).
CC   -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC       repair enzyme, which repairs dsDNA breaks with reduced fidelity.
CC       Binds linear dsDNA with 5'- and 3'- overhangs but not closed
CC       circular dsDNA nor ssDNA. Recruits and stimulates the ligase
CC       activity of LigD. {ECO:0000256|HAMAP-Rule:MF_01875}.
CC   -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000256|HAMAP-
CC       Rule:MF_01875}.
CC   -!- SIMILARITY: Belongs to the prokaryotic Ku family.
CC       {ECO:0000256|HAMAP-Rule:MF_01875}.
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DR   EMBL; CP002417; ADU34752.1; -; Genomic_DNA.
DR   RefSeq; WP_013538998.1; NC_014931.1.
DR   STRING; 595537.Varpa_0531; -.
DR   EnsemblBacteria; ADU34752; ADU34752; Varpa_0531.
DR   GeneID; 29719828; -.
DR   KEGG; vpe:Varpa_0531; -.
DR   eggNOG; ENOG4105FDF; Bacteria.
DR   eggNOG; COG1273; LUCA.
DR   HOGENOM; HOG000237248; -.
DR   KO; K10979; -.
DR   OMA; IWKGAVS; -.
DR   OrthoDB; 1724780at2; -.
DR   BioCyc; VPAR595537:G1GQO-534-MONOMER; -.
DR   Proteomes; UP000008917; Chromosome.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR   CDD; cd00789; KU_like; 1.
DR   Gene3D; 2.40.290.10; -; 1.
DR   HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR   InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR   InterPro; IPR009187; Prok_Ku.
DR   InterPro; IPR016194; SPOC-like_C_dom_sf.
DR   PANTHER; PTHR41251; PTHR41251; 1.
DR   Pfam; PF02735; Ku; 1.
DR   PIRSF; PIRSF006493; Prok_Ku; 1.
DR   SMART; SM00559; Ku78; 1.
DR   SUPFAM; SSF100939; SSF100939; 1.
DR   TIGRFAMs; TIGR02772; Ku_bact; 1.
PE   3: Inferred from homology;
DR   PRODOM; E6V5E6.
DR   SWISS-2DPAGE; E6V5E6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008917};
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA recombination {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01875};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008917}.
FT   DOMAIN       61    190       Ku. {ECO:0000259|SMART:SM00559}.
SQ   SEQUENCE   331 AA;  36720 MW;  158AB4A6AC1F6D73 CRC64;
     MPVSKKAPAP RVLWKGAISF GLVHIPVALY SATTDHGIDF DWLDKRSMDP VGYKRINKKT
     GKEITRENIV KGVEYEDGEY VVLSDKEIAA AYPKTTQTIE IETFVPANGI PFVYLERPYY
     VAPINKGAKV YALLRETLQR SERVGVARVV IQTKQHLAVL VPVGPGLVLN LLRWGADIRP
     WNDLPLPSED AKKAGLTDRE LKMAQQLVED MSGEWDPMEY KDEFKDEILR LVDRKVKAGQ
     TETVTQPDPE EGQSTEGKGA KIIDLTELLQ RSLRSKGGKT KAVANDEDED DDKEGDAPAP
     RAKPAARKRK PAAKAASKAA SKTATRHRRA A
//