(data stored in SCRATCH zone)

SWISSPROT: E6V5F0_VARPE

ID   E6V5F0_VARPE            Unreviewed;       731 AA.
AC   E6V5F0;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   08-MAY-2019, entry version 56.
DE   RecName: Full=Catalase {ECO:0000256|PIRNR:PIRNR038927, ECO:0000256|RuleBase:RU000498};
DE            EC=1.11.1.6 {ECO:0000256|PIRNR:PIRNR038927, ECO:0000256|RuleBase:RU000498};
GN   OrderedLocusNames=Varpa_0535 {ECO:0000313|EMBL:ADU34756.1};
OS   Variovorax paradoxus (strain EPS).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=595537 {ECO:0000313|EMBL:ADU34756.1, ECO:0000313|Proteomes:UP000008917};
RN   [1] {ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|Proteomes:UP000008917};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
RA   Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Orwin P.,
RA   Han J.-I.G., Woyke T.;
RT   "Complete sequence of Variovorax paradoxus EPS.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADU34756.1, ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|EMBL:ADU34756.1,
RC   ECO:0000313|Proteomes:UP000008917};
RX   PubMed=24158554;
RA   Han J.I., Spain J.C., Leadbetter J.R., Ovchinnikova G., Goodwin L.A.,
RA   Han C.S., Woyke T., Davenport K.W., Orwin P.M.;
RT   "Genome of the Root-Associated Plant Growth-Promoting Bacterium
RT   Variovorax paradoxus Strain EPS.";
RL   Genome Announc. 1:e00843-13(2013).
CC   -!- FUNCTION: Serves to protect cells from the toxic effects of
CC       hydrogen peroxide. {ECO:0000256|PIRNR:PIRNR038927}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240;
CC         EC=1.11.1.6; Evidence={ECO:0000256|PIRNR:PIRNR038927,
CC         ECO:0000256|RuleBase:RU000498};
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000256|PIRNR:PIRNR038927,
CC         ECO:0000256|PIRSR:PIRSR038927-2};
CC   -!- SIMILARITY: Belongs to the catalase family.
CC       {ECO:0000256|PIRNR:PIRNR038927, ECO:0000256|RuleBase:RU000498}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; CP002417; ADU34756.1; -; Genomic_DNA.
DR   RefSeq; WP_013539002.1; NC_014931.1.
DR   STRING; 595537.Varpa_0535; -.
DR   EnsemblBacteria; ADU34756; ADU34756; Varpa_0535.
DR   GeneID; 29714280; -.
DR   KEGG; vpe:Varpa_0535; -.
DR   eggNOG; ENOG4105CH6; Bacteria.
DR   eggNOG; COG0753; LUCA.
DR   HOGENOM; HOG000087851; -.
DR   KO; K03781; -.
DR   OMA; VMWQMSD; -.
DR   OrthoDB; 1584770at2; -.
DR   BioCyc; VPAR595537:G1GQO-537-MONOMER; -.
DR   Proteomes; UP000008917; Chromosome.
DR   GO; GO:0004096; F:catalase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0020037; F:heme binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   Gene3D; 2.40.180.10; -; 1.
DR   Gene3D; 3.40.50.880; -; 1.
DR   InterPro; IPR018028; Catalase.
DR   InterPro; IPR024708; Catalase_AS.
DR   InterPro; IPR024712; Catalase_clade2.
DR   InterPro; IPR011614; Catalase_core.
DR   InterPro; IPR037060; Catalase_core_sf.
DR   InterPro; IPR002226; Catalase_haem_BS.
DR   InterPro; IPR010582; Catalase_immune_responsive.
DR   InterPro; IPR041399; Catalase_large_C.
DR   InterPro; IPR020835; Catalase_sf.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   PANTHER; PTHR42821; PTHR42821; 1.
DR   Pfam; PF00199; Catalase; 1.
DR   Pfam; PF06628; Catalase-rel; 1.
DR   Pfam; PF18011; Catalase_C; 1.
DR   PIRSF; PIRSF038927; Catalase_clade2; 1.
DR   PRINTS; PR00067; CATALASE.
DR   SMART; SM01060; Catalase; 1.
DR   SUPFAM; SSF52317; SSF52317; 1.
DR   SUPFAM; SSF56634; SSF56634; 1.
DR   PROSITE; PS00437; CATALASE_1; 1.
DR   PROSITE; PS00438; CATALASE_2; 1.
DR   PROSITE; PS51402; CATALASE_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; E6V5F0.
DR   SWISS-2DPAGE; E6V5F0.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008917};
KW   Heme {ECO:0000256|PIRNR:PIRNR038927, ECO:0000256|PIRSR:PIRSR038927-3,
KW   ECO:0000256|RuleBase:RU000498};
KW   Hydrogen peroxide {ECO:0000256|PIRNR:PIRNR038927,
KW   ECO:0000256|RuleBase:RU000498};
KW   Iron {ECO:0000256|PIRNR:PIRNR038927, ECO:0000256|PIRSR:PIRSR038927-2,
KW   ECO:0000256|RuleBase:RU000498};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR038927,
KW   ECO:0000256|PIRSR:PIRSR038927-2, ECO:0000256|RuleBase:RU000498};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR038927,
KW   ECO:0000256|RuleBase:RU000498, ECO:0000313|EMBL:ADU34756.1};
KW   Peroxidase {ECO:0000256|PIRNR:PIRNR038927,
KW   ECO:0000256|RuleBase:RU000498, ECO:0000313|EMBL:ADU34756.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008917}.
FT   DOMAIN       44    432       Catalase. {ECO:0000259|SMART:SM01060}.
FT   ACT_SITE     91     91       {ECO:0000256|PIRSR:PIRSR038927-1}.
FT   ACT_SITE    164    164       {ECO:0000256|PIRSR:PIRSR038927-1}.
FT   METAL       378    378       Iron (heme axial ligand).
FT                                {ECO:0000256|PIRSR:PIRSR038927-2}.
FT   BINDING      88     88       Heme. {ECO:0000256|PIRSR:PIRSR038927-3}.
FT   BINDING     128    128       Heme. {ECO:0000256|PIRSR:PIRSR038927-3}.
FT   BINDING     177    177       Heme. {ECO:0000256|PIRSR:PIRSR038927-3}.
FT   BINDING     374    374       Heme. {ECO:0000256|PIRSR:PIRSR038927-3}.
FT   BINDING     385    385       Heme. {ECO:0000256|PIRSR:PIRSR038927-3}.
SQ   SEQUENCE   731 AA;  80231 MW;  57FD8BBE3C393405 CRC64;
     MTPQNKAAAG RRANATKTAK SGDGRNTKQL QLDGFTTEHP AHLTTNQGLQ IPDNHNSLKA
     GVRGPTLLED FILREKITHF DHERIPERAV HARGSAAHGY FQVYKSMSQF TSADFLQDPD
     VKTPVFVRFS TVAGERGSAD TVRDVRGFAV KFYTREGNYD LVGNNIPVFF IQDAMKFPDL
     IHAVKPEPHH AMPQAASAHD TFWDFASLMP ESTHMLMWAM SDRAIPRSYR MMEGFGVHTF
     RFVNSHGESH FVKFHWKPKL GIHGLVWDEA QKIAGKDADF HRRDLWEAIE NGDFPEWELG
     VQIIPADKEH SLGFDLLDPT KLIPEEMVPV QRIGKLVLDR NPDNFFAETE QVAFHPGHVV
     PGIDFSNDPL LQGRLFSYTD TQISRLGGAN FHELPINKGV CPFHNFQRDG MHRQTIARGQ
     VAYEPNTLGS GTEFRVDGGS NGFQSFPEAI DAPKVRRRSA SFDDHFTQAR LFFNSQSVAE
     KEHIIAAFRF ELSKLEVPAI RQRMVDNLAH VDEKLARRVA EPLGIGEPDA KAAAGRAGFR
     DHRIALPIDE SPALSMADTG DGSIRTRKIA ILVADGIDSA SLKPIREALE QAGAQCKIVG
     PRLGTVASAS KRQIDVEMTF SNTPSVMFDA VLVPAGADSA ATMSATGDAV HFVLEAYKHC
     KAICTVGEGV KLLASLGVGA DGDAPAGVVV AATPVTNLGD TTAAQQIAQD FVAAIGKHRH
     WDRANIDAVP A
//

If you have problems or comments...

PBIL Back to PBIL home page