(data stored in SCRATCH zone)

SWISSPROT: E6V5G3_VARPE

ID   E6V5G3_VARPE            Unreviewed;       630 AA.
AC   E6V5G3;
DT   08-MAR-2011, integrated into UniProtKB/TrEMBL.
DT   08-MAR-2011, sequence version 1.
DT   08-MAY-2019, entry version 53.
DE   RecName: Full=Histidine kinase {ECO:0000256|SAAS:SAAS00924638};
DE            EC=2.7.13.3 {ECO:0000256|SAAS:SAAS00924638};
GN   OrderedLocusNames=Varpa_0548 {ECO:0000313|EMBL:ADU34769.1};
OS   Variovorax paradoxus (strain EPS).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Variovorax.
OX   NCBI_TaxID=595537 {ECO:0000313|EMBL:ADU34769.1, ECO:0000313|Proteomes:UP000008917};
RN   [1] {ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|Proteomes:UP000008917};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L.,
RA   Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Orwin P.,
RA   Han J.-I.G., Woyke T.;
RT   "Complete sequence of Variovorax paradoxus EPS.";
RL   Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADU34769.1, ECO:0000313|Proteomes:UP000008917}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EPS {ECO:0000313|EMBL:ADU34769.1,
RC   ECO:0000313|Proteomes:UP000008917};
RX   PubMed=24158554;
RA   Han J.I., Spain J.C., Leadbetter J.R., Ovchinnikova G., Goodwin L.A.,
RA   Han C.S., Woyke T., Davenport K.W., Orwin P.M.;
RT   "Genome of the Root-Associated Plant Growth-Promoting Bacterium
RT   Variovorax paradoxus Strain EPS.";
RL   Genome Announc. 1:e00843-13(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|SAAS:SAAS01126420};
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DR   EMBL; CP002417; ADU34769.1; -; Genomic_DNA.
DR   RefSeq; WP_013539015.1; NC_014931.1.
DR   STRING; 595537.Varpa_0548; -.
DR   EnsemblBacteria; ADU34769; ADU34769; Varpa_0548.
DR   GeneID; 29714455; -.
DR   KEGG; vpe:Varpa_0548; -.
DR   eggNOG; ENOG410XQNC; LUCA.
DR   HOGENOM; HOG000082280; -.
DR   OMA; DIEFNRE; -.
DR   OrthoDB; 1755994at2; -.
DR   BioCyc; VPAR595537:G1GQO-550-MONOMER; -.
DR   Proteomes; UP000008917; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   CDD; cd00156; REC; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   4: Predicted;
DR   PRODOM; E6V5G3.
DR   SWISS-2DPAGE; E6V5G3.
KW   ATP-binding {ECO:0000256|SAAS:SAAS01002602};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008917};
KW   Kinase {ECO:0000256|SAAS:SAAS00924871, ECO:0000313|EMBL:ADU34769.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS01002785};
KW   Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008917};
KW   Transferase {ECO:0000256|SAAS:SAAS00924820};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Two-component regulatory system {ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM    151    174       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      175    226       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      259    475       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
FT   DOMAIN      501    621       Response regulatory.
FT                                {ECO:0000259|PROSITE:PS50110}.
FT   COILED      218    252       {ECO:0000256|SAM:Coils}.
FT   MOD_RES     552    552       4-aspartylphosphate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00169}.
SQ   SEQUENCE   630 AA;  68200 MW;  7986B17EACEBA223 CRC64;
     MNWNFRVLRG LARLTFAQQL ILLALVPATA ATLTAIAVLT RQHLGNLTEL MRANAQTVAL
     QVATVAQAPL ARMDKRALQR TAQSGTYQPH VQQVQIWTED GEIVANSETV DRARGEGLQV
     VVPIVADDGR HNGKVMVEIS LSAVQNARRS VWLNVAVVLA ISLLGVGLAG WWAARRISEP
     IRALGKAVDR LGAGEDASVA IEGTSEVKHL QLGFNHAARA LAESRRLLQS RINEATAELA
     RKNALLEVAS QAKTRLLAAA SHDLRQPLHA LTLFSDGLAN GETDPVKLQR IGHIRECVES
     LDRLFSELLN LSQLDAGVLQ PQWADFPLDR LFDEISRNFR PVAEQQGLRL VARKTELWVR
     CDYVMLSRIL NNLVSNSLRH TLEGGVLIGA RRRGKGVRID VVDTGVGIAA QHQTRVFEEF
     YQVEPAGRPS ARGARGMGLG LATVQRLTEL LNTRVELSSR LHKGTCVRVL VRSAPAALPS
     PTPSPVAAGM EDGEPSLANL RILVIDDERT ILEGLSVVLA NWGAEVLVAQ TRAEALALAD
     TWAEPPDVVV SDLLLQGGDN GLDVIAALER HPRGIGPGTA RLLVTGETKP DRLREVASAG
     IAVLYKPVSP RVLRQSIHAQ RAAALLNLDA
//

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