(data stored in ACNUC9543 zone)

SWISSPROT: E9BGX5_LEIDB

ID   E9BGX5_LEIDB            Unreviewed;      1086 AA.
AC   E9BGX5;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   08-MAY-2019, entry version 42.
DE   SubName: Full=Pre-mRNA splicing factor, putative {ECO:0000313|EMBL:CBZ34501.1};
GN   ORFNames=LDBPK_241120 {ECO:0000313|EMBL:CBZ34501.1};
OS   Leishmania donovani (strain BPK282A1).
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae;
OC   Leishmaniinae; Leishmania.
OX   NCBI_TaxID=981087 {ECO:0000313|EMBL:CBZ34501.1, ECO:0000313|Proteomes:UP000008980};
RN   [1] {ECO:0000313|EMBL:CBZ34501.1, ECO:0000313|Proteomes:UP000008980}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BPK282A1 {ECO:0000313|EMBL:CBZ34501.1,
RC   ECO:0000313|Proteomes:UP000008980};
RX   PubMed=22038251; DOI=10.1101/gr.123430.111;
RA   Downing T., Imamura H., Decuypere S., Clark T.G., Coombs G.H.,
RA   Cotton J.A., Hilley J.D., de Doncker S., Maes I., Mottram J.C.,
RA   Quail M.A., Rijal S., Sanders M., Schonian G., Stark O., Sundar S.,
RA   Vanaerschot M., Hertz-Fowler C., Dujardin J.C., Berriman M.;
RT   "Whole genome sequencing of multiple Leishmania donovani clinical
RT   isolates provides insights into population structure and mechanisms of
RT   drug resistance.";
RL   Genome Res. 21:2143-2156(2011).
RN   [2] {ECO:0000313|Proteomes:UP000008980}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BPK282A1 {ECO:0000313|Proteomes:UP000008980};
RA   Downing T., Imamura H., Sanders M., Decuypere S., Hertz-Fowler C.,
RA   Clark T.G., Rijal S., Sundar S., Quail M.A., De Doncker S., Maes I.,
RA   Vanaerschot M., Stark O., Schonian G., Dujardin J.C., Berriman M.;
RT   "Whole genome sequencing of Leishmania donovani clinical lines reveals
RT   dynamic variation related to drug resistance.";
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; FR799611; CBZ34501.1; -; Genomic_DNA.
DR   RefSeq; XP_003861203.1; XM_003861155.1.
DR   EnsemblProtists; CBZ34501; CBZ34501; LDBPK_241120.
DR   GeneDB; LdBPK_241120.1.1:pep; -.
DR   GeneID; 13390888; -.
DR   KEGG; ldo:LDBPK_241120; -.
DR   EuPathDB; TriTrypDB:LdBPK_241120.1; -.
DR   HOGENOM; HOG000175261; -.
DR   OMA; DEMGCAL; -.
DR   Proteomes; UP000008980; Chromosome 24.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   CDD; cd00079; HELICc; 1.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
DR   PRODOM; E9BGX5.
DR   SWISS-2DPAGE; E9BGX5.
KW   ATP-binding {ECO:0000256|SAAS:SAAS01176619};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008980};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01176622};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS01176608}.
FT   DOMAIN      386    550       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      575    754       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
FT   COILED      346    366       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1086 AA;  119263 MW;  2D2874275FFEB956 CRC64;
     MDAVPADHGI KRPREANSPG HTPPFVSAND VAASLQEQAQ RFISQLEMGE VLEHDRDTTE
     AVMTGTDESA QWAYGSEYYL RHDGEDDKEH PSCSHTAGST AAAAAAQESA SDAQADKARK
     VVVSLTVAPP SFFTSGNDFE TSVLSRRSAA AANKDDDDDG GDLDRRGGFV ASRFLHEALR
     TSDVDIIVPV VSHSCSLAVS ASKGSQTLAE LKRLMDRERT NRDVMDTSKS SLTQLLQKDT
     YGRMVNGEEK GVAGVGSGSA PGHAHSGSVS SFTDDRRNDN GEEEEAKYLM RQLRLEQERL
     ADMARLRGAS DASSTAPPPA AGGANSQWGS SQESRRQRKD EQLARIEGRK AQMETLADDA
     DEVERRDAMR RQRESLPIHH CKDELLRYIG ESAVTVVVGE TGSGKTTQLV QYLYQRGYAR
     HGKIIGCTQP RRLAAIGVAR RVSDEMGCAL GTTVGYSIHL DDTTTADTRV KFMTDGVLLR
     ETVNDPSLDK YSVVMLDEAH ERSVDTDVLM GVLKLALRRR GDLKLIVTSA TMDVRKFSAF
     FGNAPCYEIP GQTFPVKIHY SPTPVADYVA EAVFRVCQLH LQMPLEAKHD ILVFMTGRED
     VYGTCELIRR RLAELSPQHL STLLIMSCLS EAASAWSTEI GVLDATPAGL RKVVVATNVA
     ETSLTIDGVR YVVDCGFMKT NVYRPSIGMN TLQRYPTSQA QANQRKGRAG RTTEGTCYRL
     YTEEQYAEEM LPNSVPEIQR SSVDSVVLLL KSIGVHRLCD FDFMDAPPAA NVRSSMFHLW
     VLGFLDDAGA ITEQGQQALE FPMSPVLAKL LLESAKMGCA LEMARIVAMI SADPKNLFEL
     PKGREKVAQQ HHSRFYSNDS DHLTLLHVFT QYLDHGRSRQ WAQDHFLHSP TLARANDVFA
     QLIEKLRKVH LPIQSCGHAE TDKVRHCLAK AFALQAARRS DRRWTEYRPL LNAGVACEVH
     PASAVHARSE MPPYIIYNDL LLTHKEYLVM VTAVEPEWLV ESSRGIYEMR HGVTSSSTTT
     APSSFAVAVT TTPTPFTASR ASRASMSSSP TAPSASGSST KVCAETKAPT KKPAFGMLSS
     KRRPNI
//

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