(data stored in ACNUC7421 zone)

SWISSPROT: Q4W905_ASPFU

ID   Q4W905_ASPFU            Unreviewed;       334 AA.
AC   Q4W905;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 103.
DE   SubName: Full=NADP-dependent alcohol dehydrogenase {ECO:0000313|EMBL:EAL84214.1};
DE            EC=1.1.1.1 {ECO:0000313|EMBL:EAL84214.1};
GN   ORFNames=AFUA_6G00510 {ECO:0000313|EMBL:EAL84214.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL84214.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL84214.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL84214.1}.
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DR   EMBL; AAHF01000018; EAL84214.1; -; Genomic_DNA.
DR   RefSeq; XP_731504.1; XM_726411.1.
DR   EnsemblFungi; EAL84214; EAL84214; AFUA_6G00510.
DR   GeneID; 3503630; -.
DR   KEGG; afm:AFUA_6G00510; -.
DR   EuPathDB; FungiDB:Afu6g00510; -.
DR   HOGENOM; HOG000294667; -.
DR   InParanoid; Q4W905; -.
DR   OMA; EHDSCGH; -.
DR   OrthoDB; 1131787at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IBA:GO_Central.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006066; P:alcohol metabolic process; IBA:GO_Central.
DR   InterPro; IPR013149; ADH_C.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
DR   PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4W905.
DR   SWISS-2DPAGE; Q4W905.
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000313|EMBL:EAL84214.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          11..329
FT                   /note="PKS_ER"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   334 AA;  36025 MW;  D8A16E202CE2514F CRC64;
     MGFDFTVYKG SSDGSIKKAT THRDDLQGDS VLVRITHSGV CFTDVHYMKA DMALGHEGAG
     VVGATGPGAQ HLKKGDRVGW GYEHDSCGSC KQCLTGWETF CPERKFYGYA DLDQGSFATH
     AVWREAFLFK IPDALSNQDA APLMCGGSTV WNAIVVGEVK PVSRVGIVGI GGLGHLAIQF
     AAKMGCEVVV FSGSDNKKEE AMKLGASEFY ATKGATELKV GKPLDNLIIT TSAQPDWKLY
     LPILAPGAVI SPLTVDEKDL QIPYMPLLVG GIRIQGGIVA ARQSHRDMLD FAAHHGIKPI
     IMTYPMSVEG IQECLKTLQD GKMRYRGVLV SDKQ
//

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