(data stored in ACNUC7421 zone)

SWISSPROT: Q4W9C7_ASPFU

ID   Q4W9C7_ASPFU            Unreviewed;      1349 AA.
AC   Q4W9C7;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 2.
DT   11-DEC-2019, entry version 99.
DE   SubName: Full=ABC multidrug transporter, putative {ECO:0000313|EMBL:EAL84314.2};
DE            EC=3.6.3.- {ECO:0000313|EMBL:EAL84314.2};
GN   ORFNames=AFUA_4G01050 {ECO:0000313|EMBL:EAL84314.2};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL84314.2, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL84314.2, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC       PDR (TC 3.A.1.205) subfamily. {ECO:0000256|SAAS:SAAS00709344}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00434}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL84314.2}.
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DR   EMBL; AAHF01000017; EAL84314.2; -; Genomic_DNA.
DR   RefSeq; XP_746352.2; XM_741259.2.
DR   EnsemblFungi; EAL84314; EAL84314; AFUA_4G01050.
DR   GeneID; 3503854; -.
DR   KEGG; afm:AFUA_4G01050; -.
DR   EuPathDB; FungiDB:Afu4g01050; -.
DR   HOGENOM; HOG000162078; -.
DR   InParanoid; Q4W9C7; -.
DR   OMA; WFRWIFY; -.
DR   OrthoDB; 324553at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   CDD; cd03233; ABCG_PDR_domain1; 1.
DR   CDD; cd03232; ABCG_PDR_domain2; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013525; ABC_2_trans.
DR   InterPro; IPR003439; ABC_transporter-like.
DR   InterPro; IPR017871; ABC_transporter_CS.
DR   InterPro; IPR034001; ABCG_PDR_1.
DR   InterPro; IPR034003; ABCG_PDR_2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010929; PDR_CDR_ABC.
DR   Pfam; PF01061; ABC2_membrane; 2.
DR   Pfam; PF00005; ABC_tran; 2.
DR   Pfam; PF06422; PDR_CDR; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   3: Inferred from homology;
DR   PRODOM; Q4W9C7.
DR   SWISS-2DPAGE; Q4W9C7.
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00434,
KW   ECO:0000256|SAAS:SAAS00555301}; Hydrolase {ECO:0000313|EMBL:EAL84314.2};
KW   Membrane {ECO:0000256|SAAS:SAAS00709359, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00434,
KW   ECO:0000256|SAAS:SAAS00555311};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Repeat {ECO:0000256|SAAS:SAAS00709352};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00709342, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00709353,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00709346}.
FT   TRANSMEM        407..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        481..508
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        520..541
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        553..571
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        655..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1051..1070
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1082..1101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1121..1154
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1192..1214
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1319..1338
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          51..299
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
FT   DOMAIN          721..963
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
FT   NP_BIND         757..764
FT                   /note="ATP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   1349 AA;  151535 MW;  B09E5C45D3AA4E0D CRC64;
     MDTPSSGTID LEHGEAGLRK RLTLTFRSVS VHVTAPDAAL GDTLLSVADP RQFLGFLKGS
     RPKRTILKDV SGQVKPGEML LVLGRPGSGC TSLLRVLSND RESFDEVIGE TRYGSMDHVA
     ARRFRQQIMF NNEDDVHFPT LTVNRTMKFA LRNKVPRERP DGQGSKEFVQ EQRDNILSAL
     GIRHTTKTLV GNEFIRGVSG GERKRVSLAE VIAGQSPIQV WDNPTRGLDS KTAVEFARLL
     RREADMNQKT MVATMYQAGN GIYNEFDQVL VLADGRVTYY GPRQLAKSYF EDMGFVCPKG
     ANVADFLTSV TVLTERIVRP GMEDKVPSTA EEFEARYRQS DIHQKAMEGF DPPEKLTHEV
     DELTAAVASE KRKRHLPRSP SVYTTSLWEQ IQACTIRQFQ IMAGDRLSLI IKVVSAILQA
     LVCGSLFYNL KDDSSSIFLR PGALFFPVLY FLLESMSETT ASFMGRPILS RQKRFGFYRP
     TAFCIANAIT DIPVVLVQVS CFCIILYFMA ALQMDAGRFF TYWIIVIANT LCFMQMFRAV
     GALCKRFGNA SKITGLLSTI FFVYGGYLIP YEKMHVWFRW IFYLNPGAYA FEALMANEFV
     GKSLQCVQPD YIPYGSGYPG SESPYRGCSI PGSEGDVILG AAYIRAQYNY SWHHIWRSFG
     VIIGFWVFFI VLTALGLELL NSQGGSSVLL YKRGSQKTRS EDTTTPVQEA ARASHAKQST
     FTWHDLDYHV PYQGQKKQLL DKVFGFVKPG NLVALMGCSG AGKTTLLDVL AQRKDSGEIY
     GSILIDGRPQ GISFQRTTGY CEQMDVHEPT ATVREALVFS ALLRQPAHVP REEKLAYVDH
     IIDLLELRDI SDALIGVPGA GLSIEQRKRV TLGVELVAKP TLLFLDEPTS GLDGQSAYNI
     IRFLRKLVDG GQAVLCTIHQ PSAVLFEAFD SLLLLARGGK MAYFGETGKD SQTVLDYFAR
     HGAPCPPDEN PAEHIVEVIQ GNTDKPIDWV QVWNESEEKQ RALAQLQTLN ARGKADADYV
     EDTADYATSK WFQFTMVTKR LMVQLWRSPD YVWNKVILHV FAALFSGFTF WKIGDGAFDL
     QLRLFAIFNF IFVAPGCINQ MQPFFLHNRD IFEAREKKSK IYHWLAFIGA QTVSEIPYLI
     LCATLYFACW YFTAGFPTTA SISGHMYLQM IFYEFLYTSI GQGIAAYAPN EYFAAVMNPV
     LIGAGLVSFC GVVVPFSQMQ PFWRDWLYYL DPFTYLVGGL LGEVLWDVEV RCDPSELVRF
     RAPLGQTCGE YMAAFLAEKP GYLVDGNATA CEFCQYSTGA DYARTFNLKE RYYSWRDTGI
     TALFCVSSYA MVFLMMKLRS KKTKSARSE
//

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