(data stored in ACNUC7421 zone)

SWISSPROT: Q4W955_ASPFU

ID   Q4W955_ASPFU            Unreviewed;      1250 AA.
AC   Q4W955;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 2.
DT   11-DEC-2019, entry version 96.
DE   SubName: Full=Sensor histidine kinase/response regulator, putative {ECO:0000313|EMBL:EAL84386.2};
GN   ORFNames=AFUA_4G00320 {ECO:0000313|EMBL:EAL84386.2};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL84386.2, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL84386.2, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL84386.2}.
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DR   EMBL; AAHF01000017; EAL84386.2; -; Genomic_DNA.
DR   RefSeq; XP_746424.2; XM_741331.2.
DR   EnsemblFungi; EAL84386; EAL84386; AFUA_4G00320.
DR   GeneID; 3503741; -.
DR   KEGG; afm:AFUA_4G00320; -.
DR   EuPathDB; FungiDB:Afu4g00320; -.
DR   HOGENOM; HOG000200377; -.
DR   InParanoid; Q4W955; -.
DR   OMA; MSEDYIN; -.
DR   OrthoDB; 60843at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd00082; HisKA; 1.
DR   CDD; cd00156; REC; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00065; GAF; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   4: Predicted;
DR   PRODOM; Q4W955.
DR   SWISS-2DPAGE; Q4W955.
KW   Kinase {ECO:0000313|EMBL:EAL84386.2};
KW   Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Transferase {ECO:0000313|EMBL:EAL84386.2}.
FT   DOMAIN          587..890
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
FT   DOMAIN          1118..1249
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000259|PROSITE:PS50110"
FT   REGION          250..338
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          377..417
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        285..299
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..335
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        384..415
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1169
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   1250 AA;  137601 MW;  0687CFCDE1C0978B CRC64;
     MLEISEFCTS GRNPSPEIAM AQEREFYKYC QLPQRPGLLH RPPPSPRCEI NAELLPQSSQ
     DTTLTALAQL GALRLNARRC MISLFDRHTQ YILAESTRTL SLQDDRVYVD GDGLWLGSSV
     IPKPDGICHY CCEEDQLNAG PTGPNGGYTA LVIPDMTKDD RCSKRQYVVN APHLRFYAGV
     PIMSRRGIAI GAFAVSDGQP RAGLDPLEIR FMTDTAAAVM NHLEMMRSHE QNRRGANMIA
     GLGSFVEGAT LPSSSLRRPV HPHDDEEDQE SENSQNIIPQ TRRHHPTLAD GRPPLKERGQ
     HGEAAALPSG SHERPESEKQ PRVSSTPNHP RQPEITLASG TRVIISRAAR VLRDSLEVEG
     VVFFDASVNS YATLVRNSDG RHSDVESSSS TGDANSSSDS DNPTTGHSST ETDDSAVCDV
     LGYSTAQDDS EKMTGPMRES FLRSLLRHYP RGAIFNIDEN GGVSSSEGSD TASASYVSRE
     IVYRRDEGSK VQRRWKQRKQ ERLSLKEENK TLIKVFPAAR SVTMFPLWDS RRNRWFSGLF
     VWTAAPRVFS LTGELAYLYA FSNSIMAEIH RLDIELANKA HATLVGSISH ELRSPLHGIL
     GSTELLTDST MKPAQVALVN TIEHCGRSLL DIINNMLDFA KINQFTRKSR SSRFKSTHAL
     RRRPGLPAGI AFKDKPGLGV VNLISDVQLD AVLEEVVDSV FAGHCFSAKG GLVARPASQA
     PARDRDGHLI MKGATERPLS AFNEALTIIY DVEPGVQWLF ETQAGSWRRI LMNLFGNALK
     YTQSGYISVT LRCSSTPSNA KMKRLARGDG TREGMGSVTL TVRDTGQGID KQYLQSNVFK
     PFSQEDPLSP GSGLGLSIVH QTVVSLGGKV DITSTKGIGT EVTVTLDLPR TPQAEVAENE
     RDASIIRKAK DRVRGKSIGL IGFESSSAEE DEALVLLRLS LLRMYKEHFG MEVGLVPSNV
     SDQQVYDIYL VRQSNLDEVD QICRQVTMAE SDSRSPPMIV ICSTPQMVQK LSTTASQRPS
     TSIYEFISQP CGPSKMANSL LTCLKRQRER PSCMSAGGLD TAFLNAACAS KPRRHSENVS
     RVDFSLMPEK AIVSVTTTNV DDSAMEVTTI EATKRVPSVL LVDDNDVNLK LLVAFMKKAK
     FPYYTASNGL EALEVYKANA GYIPVVLMDI SMPVMDGLEA TREIRLFEKM HREGSTNAGH
     SCFKPTTVIV LSGLGSAPVR QEAFNSGIDL FLSKPIRFQE LVKQIDELMH
//

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