(data stored in ACNUC7421 zone)

SWISSPROT: Q4WA42_ASPFU

ID   Q4WA42_ASPFU            Unreviewed;       569 AA.
AC   Q4WA42;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 83.
DE   SubName: Full=O-methylsterigmatocystin oxidoreductase, putative {ECO:0000313|EMBL:EAL84421.1};
GN   ORFNames=AFUA_4G02730 {ECO:0000313|EMBL:EAL84421.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL84421.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL84421.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC       {ECO:0000256|RuleBase:RU000461}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL84421.1}.
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DR   EMBL; AAHF01000016; EAL84421.1; -; Genomic_DNA.
DR   RefSeq; XP_746459.1; XM_741366.1.
DR   EnsemblFungi; EAL84421; EAL84421; AFUA_4G02730.
DR   GeneID; 3503882; -.
DR   KEGG; afm:AFUA_4G02730; -.
DR   EuPathDB; FungiDB:Afu4g02730; -.
DR   HOGENOM; HOG000217305; -.
DR   InParanoid; Q4WA42; -.
DR   OMA; CEHVQAR; -.
DR   OrthoDB; 702827at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4WA42.
DR   SWISS-2DPAGE; Q4WA42.
KW   Heme {ECO:0000256|RuleBase:RU000461}; Iron {ECO:0000256|RuleBase:RU000461};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|RuleBase:RU000461};
KW   Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   569 AA;  64438 MW;  95165134623DC1A6 CRC64;
     MDPFKAIDLP LPPHFVAALG RPTVLVGFAC VFLFSQLLVW TAKYSRKKSK GLADIPGPSG
     WPIIGIGLDL PARPRKLLNS WANQFGDTFK VRVGWYNWVF FNHPDAVKEV FDRQAAVTSG
     KPPLPIAQEY CLRGDGVLPM TYNAKWKRLH AFLKQLLNAK ASAAFIPSQE FEIKQLLWDL
     SHEAGKNSTD FYMHIRRMTF SIVMTSAYGL RIPQWDCQEV RDVYGNMRML SIILSPGVFW
     IDVFPPLNWL PRFLFPSWPK AKFMAQKMHA NKMRHWNNLK ERIALGNAPD CFAKDLMESN
     YRDYGLEEET VSWLASAVPE AGAETTASAL NGMIRYLAMF PEAQARAHEE VTRILGDGRM
     ATLADEPQMP YIKAVIKETL RLCPVATTGL RRMADGDVKY RDYVIPKGTI LLANLNALHW
     DPERFPDPFS FKPERYLNHP HRSAVYAAGG DIMARDHFTF GAGRRICPGI HLAENGLFLA
     VSNLIWAYEF KLPLDEKGNE IPLDISDEGF MEGAIRVPKQ YTVRILERNP ARSRLIRESW
     EQAQKDGYIL RGVHVDADGG VRGSAKVKA
//

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