(data stored in ACNUC7421 zone)

SWISSPROT: SLT11_ASPFU

ID   SLT11_ASPFU             Reviewed;         383 AA.
AC   Q4W9V0;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 92.
DE   RecName: Full=Pre-mRNA-splicing factor slt11;
GN   Name=slt11; ORFNames=AFUA_4G03640;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. Facilitates the cooperative
CC       formation of U2/U6 helix II in association with stem II in the
CC       spliceosome. Binds to RNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SLT11 family. {ECO:0000305}.
DR   EMBL; AAHF01000016; EAL84513.1; -; Genomic_DNA.
DR   RefSeq; XP_746551.1; XM_741458.1.
DR   SMR; Q4W9V0; -.
DR   STRING; 746128.CADAFUBP00009659; -.
DR   EnsemblFungi; EAL84513; EAL84513; AFUA_4G03640.
DR   GeneID; 3504017; -.
DR   KEGG; afm:AFUA_4G03640; -.
DR   EuPathDB; FungiDB:Afu4g03640; -.
DR   HOGENOM; HOG000171086; -.
DR   InParanoid; Q4W9V0; -.
DR   KO; K12872; -.
DR   OMA; VCSHMSH; -.
DR   OrthoDB; 1272857at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   Proteomes; UP000002530; Unassembled WGS sequence.
DR   GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR   GO; GO:0071006; C:U2-type catalytic step 1 spliceosome; IBA:GO_Central.
DR   GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0036002; F:pre-mRNA binding; IBA:GO_Central.
DR   GO; GO:0017070; F:U6 snRNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   CDD; cd12265; RRM_SLT11; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR039171; Cwc2/Slt11.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR034356; Slt11_RRM.
DR   PANTHER; PTHR14089; PTHR14089; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4W9V0.
DR   SWISS-2DPAGE; Q4W9V0.
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; RNA-binding;
KW   Spliceosome.
FT   CHAIN           1..383
FT                   /note="Pre-mRNA-splicing factor slt11"
FT                   /id="PRO_0000212422"
FT   DOMAIN          242..315
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   383 AA;  42471 MW;  76971FE04C2009FD CRC64;
     MPPPQIKQDL NRSGWESTDF PSVCENCLPD NPYVQMLKED YGAECKICTR PFTIFRWKAD
     RTARTKRTTI CLTCARLKNC CQCCMLDLSF GLPIVVRDAA LKMVAPGPES SINREYYAQE
     HEKEIQEGRG AVEAYEKTDE KARELLRRLA NSEPYYRKPR QQLEGPSDDS TEAQPTDAPV
     VQSRYGNGPG PIRTSESRRG TPLPGRGRGN MRGGRAGRPF PGTAQIPPSP EDYLPPADPN
     IMSLFVTGVE DDLPEHTLRT FFTQFGQLRS LICSHRAHCA FINFATREGA EAAAQHCKGK
     AVIQGCPLRV RWGKPKPLDN MDREERMKNA REGRLTVQAQ KDGESGQRAI TAAGEPATEK
     PQSFVVAPPP GSGDVQYSSL SGD
//

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