(data stored in ACNUC7421 zone)

SWISSPROT: Q4W9U4_ASPFU

ID   Q4W9U4_ASPFU            Unreviewed;       254 AA.
AC   Q4W9U4;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 2.
DT   11-DEC-2019, entry version 79.
DE   SubName: Full=GMP synthase {ECO:0000313|EMBL:EAL84519.2};
DE            EC=6.3.5.2 {ECO:0000313|EMBL:EAL84519.2};
GN   ORFNames=AFUA_4G03700 {ECO:0000313|EMBL:EAL84519.2};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL84519.2, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL84519.2, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL84519.2}.
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DR   EMBL; AAHF01000016; EAL84519.2; -; Genomic_DNA.
DR   RefSeq; XP_746557.2; XM_741464.2.
DR   STRING; 746128.CADAFUBP00009652; -.
DR   EnsemblFungi; EAL84519; EAL84519; AFUA_4G03700.
DR   GeneID; 3503893; -.
DR   KEGG; afm:AFUA_4G03700; -.
DR   EuPathDB; FungiDB:Afu4g03700; -.
DR   HOGENOM; HOG000238441; -.
DR   InParanoid; Q4W9U4; -.
DR   KO; K01951; -.
DR   OMA; PWIQTLK; -.
DR   OrthoDB; 1450344at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003922; F:GMP synthase (glutamine-hydrolyzing) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.880; -; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR017926; GATASE.
DR   Pfam; PF00117; GATase; 1.
DR   SUPFAM; SSF52317; SSF52317; 1.
DR   PROSITE; PS51273; GATASE_TYPE_1; 1.
PE   4: Predicted;
DR   PRODOM; Q4W9U4.
DR   SWISS-2DPAGE; Q4W9U4.
KW   Glutamine amidotransferase {ECO:0000256|PROSITE-ProRule:PRU00605};
KW   Ligase {ECO:0000313|EMBL:EAL84519.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT   DOMAIN          20..211
FT                   /note="Glutamine amidotransferase type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51273"
FT   ACT_SITE        109
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT   ACT_SITE        195
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT   ACT_SITE        197
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ   SEQUENCE   254 AA;  28250 MW;  F736860161F3D2EF CRC64;
     MARLLRAAIL ECDTPIQPVK DRYGTYGDLF ENLLKASLKA QGLDPQVDLQ ITKWDVVNGS
     VYPEPDDCDA ILLTGSKHDA FADEPWIIKL TNYTRELYEK HKKPIIGICF GHQIIARALG
     ARVGRSDRGW EIAVEPIILT DTGRVLFSKN VLSLHQMHRD IAYEVPEGCV NLGSSAICEI
     HGLYRAGRIF SVQGHPEYDE FVVSKLIETR HAMGVFDDQL SKDGLSRAGK PHDGLVVGEA
     ICKFLLDDPG VNRV
//

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