(data stored in ACNUC7421 zone)

SWISSPROT: Q4W9N6_ASPFU

ID   Q4W9N6_ASPFU            Unreviewed;       286 AA.
AC   Q4W9N6;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 75.
DE   RecName: Full=Pyridoxal phosphate homeostasis protein {ECO:0000256|HAMAP-Rule:MF_03225};
DE            Short=PLP homeostasis protein {ECO:0000256|HAMAP-Rule:MF_03225};
GN   ORFNames=AFUA_4G04300 {ECO:0000313|EMBL:EAL84577.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL84577.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL84577.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be
CC       involved in intracellular homeostatic regulation of pyridoxal 5'-
CC       phosphate (PLP), the active form of vitamin B6. {ECO:0000256|HAMAP-
CC       Rule:MF_03225}.
CC   -!- SIMILARITY: Belongs to the pyridoxal phosphate-binding protein
CC       YggS/PROSC family. {ECO:0000256|HAMAP-Rule:MF_03225,
CC       ECO:0000256|RuleBase:RU004514}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL84577.1}.
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DR   EMBL; AAHF01000016; EAL84577.1; -; Genomic_DNA.
DR   RefSeq; XP_746615.1; XM_741522.1.
DR   STRING; 746128.CADAFUBP00009593; -.
DR   EnsemblFungi; EAL84577; EAL84577; AFUA_4G04300.
DR   GeneID; 3503999; -.
DR   KEGG; afm:AFUA_4G04300; -.
DR   EuPathDB; FungiDB:Afu4g04300; -.
DR   HOGENOM; HOG000048983; -.
DR   InParanoid; Q4W9N6; -.
DR   KO; K06997; -.
DR   OMA; LQWHFIG; -.
DR   OrthoDB; 1423577at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
DR   Gene3D; 3.20.20.10; -; 1.
DR   HAMAP; MF_02087; PLP_homeostasis; 1.
DR   InterPro; IPR001608; Ala_racemase_N.
DR   InterPro; IPR029066; PLP-binding_barrel.
DR   InterPro; IPR011078; PyrdxlP_homeostasis.
DR   PANTHER; PTHR10146; PTHR10146; 1.
DR   Pfam; PF01168; Ala_racemase_N; 1.
DR   SUPFAM; SSF51419; SSF51419; 1.
DR   TIGRFAMs; TIGR00044; TIGR00044; 1.
DR   PROSITE; PS01211; UPF0001; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4W9N6.
DR   SWISS-2DPAGE; Q4W9N6.
KW   Pyridoxal phosphate {ECO:0000256|HAMAP-Rule:MF_03225};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT   DOMAIN          55..278
FT                   /note="Ala_racemase_N"
FT                   /evidence="ECO:0000259|Pfam:PF01168"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         63
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03225"
SQ   SEQUENCE   286 AA;  31285 MW;  F69A96A133507A9D CRC64;
     MTPTEQQEQE QPSPTSTTIM PASPSRTGTL LANLSSVTSR ISTAALNANR PATKPIRLIA
     VSKLKPAADI LALHNPPTNH LHFGENYLQE LLEKSKLLPP SIRWHFIGGL QSNKCVTLAR
     DVRGLWAVES VDSEKKASLL DRGWGERSEE VRGVALEDRL RVFVQVNTSG EENKAGVDPV
     AGAVPLARFI REKCPRLKLQ GVMTIGAIAR SKATTPETEN EDFVCLRETR DRIVRELGLQ
     GDDAELELSM GMSEDFEGAI KLGSDEVRVG TTIFGERPPK SEAKVV
//

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