(data stored in ACNUC7421 zone)

SWISSPROT: TOF1_ASPFU

ID   TOF1_ASPFU              Reviewed;        1176 AA.
AC   Q4W9M7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 2.
DT   11-DEC-2019, entry version 71.
DE   RecName: Full=Topoisomerase 1-associated factor 1;
GN   Name=tof1; ORFNames=AFUA_4G04390;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Forms a fork protection complex (FPC) with csm3 and which is
CC       required for chromosome segregation during meiosis and DNA damage
CC       repair. FPC coordinates leading and lagging strand synthesis and moves
CC       with the replication fork. FPC stabilizes replication forks in a
CC       configuration that is recognized by replication checkpoint sensors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC       tof1 and csm3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the timeless family. {ECO:0000305}.
DR   EMBL; AAHF01000016; EAL84586.2; -; Genomic_DNA.
DR   RefSeq; XP_746624.2; XM_741531.2.
DR   STRING; 746128.CADAFUBP00009583; -.
DR   EnsemblFungi; EAL84586; EAL84586; AFUA_4G04390.
DR   GeneID; 3503983; -.
DR   KEGG; afm:AFUA_4G04390; -.
DR   EuPathDB; FungiDB:Afu4g04390; -.
DR   HOGENOM; HOG000048676; -.
DR   InParanoid; Q4W9M7; -.
DR   KO; K10997; -.
DR   OMA; MTVNHHR; -.
DR   OrthoDB; 839367at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   Proteomes; UP000002530; Unassembled WGS sequence.
DR   GO; GO:0000790; C:nuclear chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0031298; C:replication fork protection complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0000076; P:DNA replication checkpoint; IBA:GO_Central.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0043111; P:replication fork arrest; IBA:GO_Central.
DR   GO; GO:0048478; P:replication fork protection; IBA:GO_Central.
DR   InterPro; IPR006906; Timeless.
DR   InterPro; IPR007725; TIMELESS_C.
DR   Pfam; PF04821; TIMELESS; 1.
DR   Pfam; PF05029; TIMELESS_C; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4W9M7.
DR   SWISS-2DPAGE; Q4W9M7.
KW   Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..1176
FT                   /note="Topoisomerase 1-associated factor 1"
FT                   /id="PRO_0000301729"
SQ   SEQUENCE   1176 AA;  134897 MW;  236EADF236015816 CRC64;
     MDEEGAPLSE GVQVVDPDVR AHVYSLVTAL GGFNGESADR YVLGDDALAC LRDIKRWLKL
     YDEKHNRMDV ARCLGEANLV NGDLLPILTL WSTSGQKSKH MSRIALACLE LLVPLTWPLE
     VHSEMTVNHH RHTPYLQQAQ VLYKRGILSH GSGSILRTII RIGLPSMAVP RSERTTRDEG
     ILKLMLYFLR NIAVISPNAR LAAEGDEEET SRSATINAFQ NQDAFALLLT MCSNVGEDFS
     LQDVVLLEIL FHIVKGVNVE KLFMNDAQRK AKRTDELGEL LQKESSLRRE YAKNAPTRHG
     RFGTMIWVKR DDAKVSTVSG QDVLKDSQTT LHKMDQSKKW NKPQIRRRAA EVTANNDFNT
     PVNINSTATK NLRMFVEEFL DSGFNPLFTH VRKAIEREAD RVMDINTRQF FYTVAWFLEA
     ERVRRAHQRE KRHLGDTPLK EIEPDSFALV ASVLNQETFV FLNRSMQYSY DNKDVEDLTA
     EMRCFTQILL TVQEMAQSPL EEDQEIADNI QNRIFYEETT HDRIVAIVRG YKDQGFGYLD
     ACTELAHVFL RMLEHYSKEN VDMHVRSRRR AKRKAKQAKQ ADIEGDDEEE ASEEEDLMDV
     ERISKERKFD FRRFAAKFCN QSCVDTFIAF TKYYRELNVD QLKRAHRYFY RIAFKQEMSV
     LLFRLDIINL FYRMIKGPGA LDSNKPIFKE WEELVRQIIR RMIKKIDQRP ALITELLFSK
     INSTVFYLEY GHEKQTISAS KRPPAELEVE PREAKTIDEK IRIVVHVMVK DEHTDLVKWV
     SDVLNSAADE REAWESQEQH SGGQKAPNPM IPVKSDNESC QKAMFSNAKL RLLMSLVRFE
     RLGMEDVPGA SWVVPSSLNS QELRHTRSII EQCLTEPVTE NSDRDLSQLI RRKSGNNTRR
     DRDDQMANVD FGSDSEGDDN VPDGPLFPPN PRSRANALEQ LKKQRKKRRK QAGEEEEPDE
     EDLEARRRAR LENALARQAK IKSDLYIHAS DEETDEEADQ EFFRLEEQRR KEQAERIRKA
     LLHGVVEEVS ENSRKKSSGR KRQSDQYTAS TADSQSKRQR RLQQTEGLDG NDDLVVAGTE
     ARSPDSLGQG SPSLKGANDV EDTLVTSEEN ELDFDDDLAF SRNRTRDKVL SAENDDSDTE
     PPAPDTIDED GEEAAAVAAP PRRRVRAGFV IESDSE
//

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