(data stored in ACNUC7421 zone)

SWISSPROT: Q4W9J8_ASPFU

ID   Q4W9J8_ASPFU            Unreviewed;      1117 AA.
AC   Q4W9J8;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 76.
DE   SubName: Full=Calcium permease family membrane transporter {ECO:0000313|EMBL:EAL84615.1};
GN   ORFNames=AFUA_4G04670 {ECO:0000313|EMBL:EAL84615.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL84615.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL84615.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC       family. {ECO:0000256|SAAS:SAAS00611730}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL84615.1}.
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DR   EMBL; AAHF01000016; EAL84615.1; -; Genomic_DNA.
DR   RefSeq; XP_746653.1; XM_741560.1.
DR   STRING; 746128.CADAFUBP00009554; -.
DR   EnsemblFungi; EAL84615; EAL84615; AFUA_4G04670.
DR   GeneID; 3503963; -.
DR   KEGG; afm:AFUA_4G04670; -.
DR   EuPathDB; FungiDB:Afu4g04670; -.
DR   HOGENOM; HOG000170275; -.
DR   InParanoid; Q4W9J8; -.
DR   KO; K07300; -.
DR   OMA; WKYTIDG; -.
DR   OrthoDB; 312952at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015369; F:calcium:proton antiporter activity; IBA:GO_Central.
DR   GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR005185; YccF.
DR   Pfam; PF01699; Na_Ca_ex; 2.
DR   Pfam; PF03733; YccF; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4W9J8.
DR   SWISS-2DPAGE; Q4W9J8.
KW   Membrane {ECO:0000256|SAAS:SAAS00087576, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00460754, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00460801,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        274..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        508..527
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        539..559
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        571..595
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        607..627
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        639..662
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        707..727
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        926..946
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        958..982
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        994..1015
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1035..1052
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1064..1082
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          271..323
FT                   /note="YccF"
FT                   /evidence="ECO:0000259|Pfam:PF03733"
FT   DOMAIN          542..726
FT                   /note="Na_Ca_ex"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
FT   DOMAIN          926..1075
FT                   /note="Na_Ca_ex"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
FT   REGION          1..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          150..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          797..835
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..85
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..200
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..216
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1117 AA;  123586 MW;  8A1C813C4CA1FEB5 CRC64;
     MDNSQRVPDI SRFSQAETTS RLSSTVSTGS TSSDTIRPTR PMANSRRSYG TISSSDLADF
     DTLPNDGQAD NSSRIPSSQS PSVAALPSDR PRKPSVTRRI SSRRQVPHKG QEFSTDDDVQ
     EVEEDIAMQQ QGSNPQPSPR LRPLRKQSST LRRRLNARPS PLARADSDND SGEESLLPES
     CMEAIGTRPP SQQSEASSHH GINHGDGDND ETSDAESFTL KDRQQAINET HPFGIRLWKP
     ALYKKSRSVE KTAEGDIHSS PGGRVGNILF LANLLWTAFF GWWLALAALF GAIACFIFAY
     SPSAVEYGKV FWGLSWYLLY PFGSFVRLET DEHYAEEDEG EGRSISEYEQ WQNGDLEHGR
     LFFGPRSSRS LVGRRRNSID SVSEQDSLLG RTQRISPRES NLHSKRRLFG RGEWTLGRVV
     FFVFFYFLIG PLMLFVSMVC WLLVFWIPMG RVTLILFDHL RRHPLALSFH SDTSYTRLSP
     GSPSSILLCT YRAAGLSYWK YTVDGTNIFL INLLGVVLFV IIDYFLLAET LGLHNWMTHP
     GFVFTLALVS IIPLAYFIGQ AVASISAQSS MGLGAAVNAF FSTVVEVYLY CVALTEGKGQ
     LVEGSIIGSI FAGILFLPGL SMCFGAIRRK TQRFNVKSAG VTSTMLMFAV IAAFGPTLFY
     QIYGSHELNC YSCAETTDSG IKDCRRCYFA QVPAVDDNFF RKVVQPYSWF AALFLFLSYI
     IGLWFTLRTH AALIWATEVE EKKAAVLQQE QSAYEPRHLL SPAGTANATS SNAKGSIRDS
     QLYKRILGQS LKQVGLSENA NEDASHQPES SSARDKGAMP YIVPPRTEDE DGYSSFKGFR
     GYTGEENEDL VRQVTEVAAT AAAVAARDVA RTRKPSVQQG TARHSNKITG DLSKSVLEDQ
     EDVGIEHTHA SGGHDAPNWS KAKSSIILLV ATILYAIIAE ILVNTVDVVL ESVDIDEKFL
     GITLFALVPN TTEFLNAISF AMNGNIALSM EIGSAYALQV CLLQIPALVL FSALYSRILD
     PSDLLTHSFN LIFPQWDMVS VILCVFLLSY VYGEGKSNYF KGSILVLTYL VVVIGFYLAG
     YSNVDTMGVD RFDTLALGPI RSENFHTIGQ PTRGMAF
//

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