(data stored in ACNUC7421 zone)

SWISSPROT: Q4W9I3_ASPFU

ID   Q4W9I3_ASPFU            Unreviewed;       296 AA.
AC   Q4W9I3;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 81.
DE   SubName: Full=C-4 methyl sterol oxidase Erg25, putative {ECO:0000313|EMBL:EAL84630.1};
DE            EC=1.-.-.- {ECO:0000313|EMBL:EAL84630.1};
GN   ORFNames=AFUA_4G04820 {ECO:0000313|EMBL:EAL84630.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL84630.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL84630.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- SIMILARITY: Belongs to the sterol desaturase family.
CC       {ECO:0000256|SAAS:SAAS00565350}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL84630.1}.
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DR   EMBL; AAHF01000016; EAL84630.1; -; Genomic_DNA.
DR   RefSeq; XP_746668.1; XM_741575.1.
DR   STRING; 746128.CADAFUBP00009538; -.
DR   EnsemblFungi; EAL84630; EAL84630; AFUA_4G04820.
DR   GeneID; 3503949; -.
DR   KEGG; afm:AFUA_4G04820; -.
DR   EuPathDB; FungiDB:Afu4g04820; -.
DR   HOGENOM; HOG000162289; -.
DR   InParanoid; Q4W9I3; -.
DR   KO; K07750; -.
DR   OMA; IHHEFQA; -.
DR   OrthoDB; 1493916at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0000254; F:C-4 methylsterol oxidase activity; IBA:GO_Central.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0006696; P:ergosterol biosynthetic process; IBA:GO_Central.
DR   GO; GO:0016126; P:sterol biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR006694; Fatty_acid_hydroxylase.
DR   Pfam; PF04116; FA_hydroxylase; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4W9I3.
DR   SWISS-2DPAGE; Q4W9I3.
KW   Oxidoreductase {ECO:0000313|EMBL:EAL84630.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT   DOMAIN          140..276
FT                   /note="Fatty acid hydroxylase"
FT                   /evidence="ECO:0000259|Pfam:PF04116"
SQ   SEQUENCE   296 AA;  34910 MW;  67C1FDB6D31428ED CRC64;
     MNSTLYSTSP GTYWEQYEEV SQHSAHLNVV ERLWSAWYAW MQNDVLATGI MSFVMHEIVY
     FGRSVPWILI DTLGLFKNYK IQNNKIPSLR EQWDCAKFVL LSHFTVELPQ IWLFHPMAQF
     FGLSTSVPFP SVWTMMYQIA IFFVLEDTWH YFSHRALHWG PLYKAIHKIH HQYSAPFGMA
     AEYASPIEVM ILGFGTVGCP ILWCALTGDL HIFTMYVWIV LRLFQAIDAH SGYEFPWSLH
     HFLPFWAGAD HHDLHHEKFV GNYSSSFRWW DYLLDTEYTP EALKRRREGK LTKKAQ
//

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