(data stored in ACNUC7421 zone)

SWISSPROT: Q4WDG5_ASPFU

ID   Q4WDG5_ASPFU            Unreviewed;       249 AA.
AC   Q4WDG5;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 78.
DE   RecName: Full=Derlin {ECO:0000256|RuleBase:RU363059};
GN   ORFNames=AFUA_6G04670 {ECO:0000313|EMBL:EAL85573.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL85573.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL85573.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: May be involved in the degradation of misfolded endoplasmic
CC       reticulum (ER) luminal proteins. {ECO:0000256|RuleBase:RU363059}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU363059}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU363059}.
CC   -!- SIMILARITY: Belongs to the derlin family.
CC       {ECO:0000256|RuleBase:RU363059}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL85573.1}.
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DR   EMBL; AAHF01000012; EAL85573.1; -; Genomic_DNA.
DR   RefSeq; XP_747611.1; XM_742518.1.
DR   STRING; 746128.CADAFUBP00009100; -.
DR   EnsemblFungi; EAL85573; EAL85573; AFUA_6G04670.
DR   GeneID; 3505211; -.
DR   KEGG; afm:AFUA_6G04670; -.
DR   EuPathDB; FungiDB:Afu6g04670; -.
DR   HOGENOM; HOG000200948; -.
DR   InParanoid; Q4WDG5; -.
DR   KO; K13989; -.
DR   OMA; IVVGHIW; -.
DR   OrthoDB; 1609512at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0000839; C:Hrd1p ubiquitin ligase ERAD-L complex; IBA:GO_Central.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0051787; F:misfolded protein binding; IBA:GO_Central.
DR   GO; GO:1990381; F:ubiquitin-specific protease binding; IBA:GO_Central.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR   GO; GO:0071712; P:ER-associated misfolded protein catabolic process; IMP:AspGD.
DR   GO; GO:0030448; P:hyphal growth; IGI:AspGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:AspGD.
DR   GO; GO:0032940; P:secretion by cell; IGI:AspGD.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   InterPro; IPR007599; DER1.
DR   Pfam; PF04511; DER1; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4WDG5.
DR   SWISS-2DPAGE; Q4WDG5.
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU363059};
KW   Membrane {ECO:0000256|RuleBase:RU363059};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Transmembrane {ECO:0000256|RuleBase:RU363059};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363059}.
FT   TRANSMEM        29..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363059"
FT   TRANSMEM        65..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363059"
FT   TRANSMEM        108..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363059"
FT   TRANSMEM        153..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363059"
SQ   SEQUENCE   249 AA;  28724 MW;  9C61DD4D6D4C8ACD CRC64;
     MAAIWGNGGQ GGQFPLEQWF YEMPPVTRWW TVATVATSVL VQCHILTPFQ LFYSFRAVYF
     KSQYWRLLTT FLYFGPLNLD LLFHVFFLQR YSRLLEESSG RSPAHFSWLL FYAMTSLLLI
     SPFLSLPFLG TALSSSLVYI WSRRNPDTRL SFLGILVFTA PYLPWVLMAF SLVVHGIVPK
     DEICGIVVGH IWYFFNDVYP SLHGGHRPLD PPRWWRRIFD PRAAAGEAQR TDTDNVNRDF
     AAAAAPEVR
//

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