(data stored in ACNUC7421 zone)

SWISSPROT: Q4WDF2_ASPFU

ID   Q4WDF2_ASPFU            Unreviewed;       193 AA.
AC   Q4WDF2;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 95.
DE   SubName: Full=Calcineurin Ca2+-binding regulatory subunit CnaB {ECO:0000313|EMBL:EAL85586.1};
GN   ORFNames=AFUA_6G04540 {ECO:0000313|EMBL:EAL85586.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL85586.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL85586.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
RN   [2] {ECO:0000213|PDB:6TZ7}
RP   X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 21-193.
RX   PubMed=31537789; DOI=10.1038/s41467-019-12199-1;
RA   Juvvadi P.R., Fox D., Bobay B.G., Hoy M.J., Gobeil S.M.C., Venters R.A.,
RA   Chang Z., Lin J.J., Averette A.F., Cole D.C., Barrington B.C.,
RA   Wheaton J.D., Ciofani M., Trzoss M., Li X., Lee S.C., Chen Y.L., Mutz M.,
RA   Spicer L.D., Schumacher M.A., Heitman J., Steinbach W.J.;
RT   "Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive
RT   fungal pathogens to develop antifungal agents.";
RL   Nat. Commun. 10:4275-4275(2019).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL85586.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAHF01000012; EAL85586.1; -; Genomic_DNA.
DR   RefSeq; XP_747624.1; XM_742531.1.
DR   PDB; 6TZ7; X-ray; 2.50 A; B=21-193.
DR   PDBsum; 6TZ7; -.
DR   SMR; Q4WDF2; -.
DR   STRING; 746128.CADAFUBP00009113; -.
DR   EnsemblFungi; EAL85586; EAL85586; AFUA_6G04540.
DR   GeneID; 3505202; -.
DR   KEGG; afm:AFUA_6G04540; -.
DR   EuPathDB; FungiDB:Afu6g04540; -.
DR   HOGENOM; HOG000233019; -.
DR   InParanoid; Q4WDF2; -.
DR   KO; K06268; -.
DR   OMA; VDKTMME; -.
DR   OrthoDB; 1271942at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   Pfam; PF13202; EF-hand_5; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   SMART; SM00054; EFh; 4.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 4.
DR   PROSITE; PS50222; EF_HAND_2; 4.
PE   1: Evidence at protein level;
DR   PRODOM; Q4WDF2.
DR   SWISS-2DPAGE; Q4WDF2.
KW   3D-structure {ECO:0000213|PDB:6TZ7};
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT   DOMAIN          40..75
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          79..107
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          109..144
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          150..185
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   CA_BIND         53..64
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00448"
FT   CA_BIND         85..96
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00448"
FT   CA_BIND         122..133
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00448"
FT   CA_BIND         163..174
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00448"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   193 AA;  21886 MW;  866EC370F8A78885 CRC64;
     MEQPSEPNNA AMYDARRRRA SVGTSQLLDN IVSASNFDRD EVDRLRKRFM KLDKDSSGTI
     DRDEFLSLPQ VSSNPLATRM IAIFDEDGGG DVDFQEFVSG LSAFSSKGNK EEKLRFAFKV
     YDIDRDGYIS NGELFIVLKM MVGNNLKDVQ LQQIVDKTIM EADKDRDGKI SFEEFTEMVE
     NTDVSLSMTL SMF
//

If you have problems or comments...

PBIL Back to PBIL home page