(data stored in ACNUC7421 zone)

SWISSPROT: Q4WDF0_ASPFU

ID   Q4WDF0_ASPFU            Unreviewed;       492 AA.
AC   Q4WDF0;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 83.
DE   RecName: Full=Ribosomal lysine N-methyltransferase 4 {ECO:0000256|PIRNR:PIRNR011771};
DE            EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR011771};
GN   ORFNames=AFUA_6G04520 {ECO:0000313|EMBL:EAL85588.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL85588.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL85588.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: S-adenosyl-L-methionine-dependent protein-lysine N-
CC       methyltransferase that monomethylates 60S ribosomal protein L42.
CC       {ECO:0000256|PIRNR:PIRNR011771}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR011771}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
CC       {ECO:0000256|PIRNR:PIRNR011771}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL85588.1}.
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DR   EMBL; AAHF01000012; EAL85588.1; -; Genomic_DNA.
DR   RefSeq; XP_747626.1; XM_742533.1.
DR   STRING; 746128.CADAFUBP00009115; -.
DR   EnsemblFungi; EAL85588; EAL85588; AFUA_6G04520.
DR   GeneID; 3505227; -.
DR   KEGG; afm:AFUA_6G04520; -.
DR   EuPathDB; FungiDB:Afu6g04520; -.
DR   HOGENOM; HOG000201152; -.
DR   InParanoid; Q4WDF0; -.
DR   KO; K05302; -.
DR   OMA; VAMVPMA; -.
DR   OrthoDB; 490654at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; IBA:GO_Central.
DR   Gene3D; 3.90.1420.10; -; 1.
DR   InterPro; IPR011383; N-lys_methylase_SETD6.
DR   InterPro; IPR015353; Rubisco_LSMT_subst-bd.
DR   InterPro; IPR036464; Rubisco_LSMT_subst-bd_sf.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF09273; Rubis-subs-bind; 1.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF011771; RMS1_SET; 2.
DR   SUPFAM; SSF81822; SSF81822; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4WDF0.
DR   SWISS-2DPAGE; Q4WDF0.
KW   Methyltransferase {ECO:0000256|PIRNR:PIRNR011771};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR011771};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   S-adenosyl-L-methionine {ECO:0000256|PIRNR:PIRNR011771};
KW   Transferase {ECO:0000256|PIRNR:PIRNR011771}.
FT   DOMAIN          34..279
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   REGION          210..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          464..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..225
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   492 AA;  54456 MW;  975A32264E333042 CRC64;
     MSSTTHFPDS DSFQRQSDEF ITWLAGKPGV KINSKISIAD LRSKSAGRGV VARSDIFDGE
     ELFSIPRGLV LSAQNSKLKD LLSQDLEELG PWLSLILVMM YEYLLGEQSA WAPYFKILPK
     SFDTLMFWSP SELRELQGSA IVSKIGKEGA EDSIMQMIAP VVRANPSLFP SVDGLASWDG
     EAGSHALLRL AHIMGSLIMA YAFDIEKVED EDDENNDEED GYVTDDEQDQ SSKGMVPLAD
     ILNADADRNN ARLFQEDDSL VMKAIKPIRV GEEIFNDYGE LPRADLLRRY GYVTDNYAQY
     DVVELSLDQI CRSAGLQNAD IESYPPLAFL EDLELLDDGY VIPRPSPEDS LTDFLPDELL
     VLVKTLTLSS EQLEHQKSKS KAPKPSFGHA EAAILLKAVQ LVGSQYPTTV AQDEEILSGL
     VQSEAFQPLN QTDRRQKMAI QVRLGEKYIL QTLANMLEKF ITNSAQSNGG SGLKRGANGD
     SGDSRRTKAP KN
//

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