(data stored in ACNUC7421 zone)

SWISSPROT: SEC16_ASPFU

ID   SEC16_ASPFU             Reviewed;        1832 AA.
AC   Q4WD95;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 85.
DE   RecName: Full=COPII coat assembly protein sec16;
DE   AltName: Full=Protein transport protein sec16;
GN   Name=sec16; ORFNames=AFUA_6G03960;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Involved in the initiation of assembly of the COPII coat
CC       required for the formation of transport vesicles from the endoplasmic
CC       reticulum (ER) and the selection of cargo molecules. Also involved in
CC       autophagy (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Cytoplasmic side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SEC16 family. {ECO:0000305}.
DR   EMBL; AAHF01000012; EAL85643.1; -; Genomic_DNA.
DR   RefSeq; XP_747681.1; XM_742588.1.
DR   SMR; Q4WD95; -.
DR   STRING; 746128.CADAFUBP00009169; -.
DR   EnsemblFungi; EAL85643; EAL85643; AFUA_6G03960.
DR   GeneID; 3505046; -.
DR   KEGG; afm:AFUA_6G03960; -.
DR   EuPathDB; FungiDB:Afu6g03960; -.
DR   HOGENOM; HOG000048639; -.
DR   InParanoid; Q4WD95; -.
DR   KO; K20353; -.
DR   OMA; AAHICFI; -.
DR   OrthoDB; 56582at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   Proteomes; UP000002530; Unassembled WGS sequence.
DR   GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:GOC.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0048208; P:COPII vesicle coating; IBA:GO_Central.
DR   GO; GO:0007029; P:endoplasmic reticulum organization; IBA:GO_Central.
DR   GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR   GO; GO:0070863; P:positive regulation of protein exit from endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0070973; P:protein localization to endoplasmic reticulum exit site; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd09233; ACE1-Sec16-like; 1.
DR   InterPro; IPR024298; ACE1_Sec16_Sec31.
DR   InterPro; IPR024880; Sec16.
DR   InterPro; IPR024340; Sec16_CCD.
DR   InterPro; IPR024468; Sec16_N.
DR   Pfam; PF12932; Sec16; 1.
DR   Pfam; PF12931; Sec16_C; 1.
DR   Pfam; PF12935; Sec16_N; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4WD95.
DR   SWISS-2DPAGE; Q4WD95.
KW   Autophagy; Endoplasmic reticulum; ER-Golgi transport; Membrane;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..1832
FT                   /note="COPII coat assembly protein sec16"
FT                   /id="PRO_0000295529"
FT   COMPBIAS        350..382
FT                   /note="Asp-rich"
FT   COMPBIAS        507..878
FT                   /note="Pro-rich"
FT   COMPBIAS        1697..1793
FT                   /note="Pro-rich"
SQ   SEQUENCE   1832 AA;  194987 MW;  4FD33EBF7E665837 CRC64;
     MAQPEGVLAW NPAFRPEDND SVATDLARLA LDSGKEVSET TDVDTHVSPP AEEFTDENGS
     IESKTAISAD TSDQGAPDLV DSNTPAADNG SKPDTEEPDK PSRDESIFMQ TDKSRAVEDV
     TENVPTENGN VDITSGLEEH VAEEPHYEGP EKSTGLAGRN DAQDLFEGND TAWMDEAEGE
     VNGATVNGEA SGTRPGFWDS LGDNERDNED DFFNQLKTQT KPIYSPPETE ARFEEGIPLL
     GQGAAPQNNH AHKGESQVDD VFGDDEDDES GFFSEIQKRT SAEGPPPITR KSTSQVIDSI
     NAVSDSMFSK QLPAAAELNN SLAVPTADGE IKNSPSEEDL AARWQAELSD DADETMPTED
     DLAARWQAEL DDDDDDLLLD DDTTNAQRPP EAANIDHMND TSMLQSPFGT PENLARPKVQ
     PVSYTPHQPS TSDLLSGIPA QNTAAQPTNA SMSSYFSAQA PPNPVTTRAE SFAERSKEGY
     KSPYDIPEDL ARPRRAVANS RTVVAQPGTV PKPPPRSSSI PAPPLKASTV SPAPLGTSST
     APTAPQKNFF EELPLPPPRP KSRPASSGRY TPNAPVSAPS LPQSIPPPAN QYSNVPGAPQ
     SNIGPPDPPQ LQQPERLDPY SNLLAPNVPS APAVPSTASR YSPRPPGVQA GVKPPPSPRY
     SPAPPQSTNA VAAAPRNRYA SQPASISGQG AALQFQPRTS SPLAYHEKIH YEDQGQSEER
     PQLQSTASPP PLNHSHPSEQ PVSSENKGPS GVDVLENVPP LSTRPQSPPK NPYAPSAYTN
     EFANRVAPVS TGPPIAGMTG VLNSSTEESP FVPPRRSQTQ SPSQTLSPRL SVPSLDPFQR
     PASVHGSTSP TRTVNPYAPA PVPTHNRAPS QVLEFIPPTD GQQLDSLERW KGAPIFKFGF
     GGAVISCFPK HIPRYSAGQA APMIKSCPGE VRISQLNDWL PAAEGIVQHP GPLKGKSKKK
     DLVAWLSSKI AAFENADIPD FDRLSPDASK LREEKTLLWK VIRVLVENDG VLEGSVEAQK
     SLRNLLFPNL QDSGPNQSLG DVFTPSATLQ PLNAPSQPDA VDSRSVDLLR DTLVLGEREK
     AVWAAVDKRL WGHAMIIASR MDRSVWQQVV QEFVRREVRS ATSRTESLAA FYEILAGNIE
     ESIDELVPPS ARAGLQMISK VDGHGPAKNS LDGLDSWRET VGLVLSNRSP DDQRALVALG
     RLLLSYNRTE AAHICFILSR VAVFGGLDDP QANIVLLGVD HQRLSSCAAL YNDDSILLTE
     AYEFATSVLA GSSVSTLPHL LAFKLIHAWS LAERGRKSEA QQYCDAIAAA LKATTKPSGY
     HNQHLFFGVD ELSARLRETT SDGGSSWISR PSMEKVSGSM WAKFNSFVAG DDSDAASTGS
     VKAEEIGPFA RVSGTPTISR SPSVSDIYGS YPVAAAQPLP ATGPSRYQPV SQYAPSASPE
     QLRGRSSMDS QRSASFGYPL GQRRGSQEPS TPVDTNMFHG MPMYGSPPVA GYQSTPPQSS
     YMPLAPVAED SASGAQQESF SAHSQVSDNA PSHRSSTYAP EPFGHPFDTQ AVSTTSQPDQ
     GGYMPPTSSG AYEPPSFESN TESADGAQDE STEEDKPKKK SIMDEDDDED LAARAAAIQK
     AERARRDREA DEAFRKAAEA DAKKPPPATG KKGWFSGWFG GKKDDNSGGG PIRAKLGEEN
     SFYYDTELKK WVNKKDPGSA APTRGTPPPP KGSAPPSRSM SGSGGPPPAM ATPPPTGASG
     SRPSSSAGAP TSVSASPAPP SLGAPPPAIP RSVSTGAVLP TPPSSSAGAP PRPATSLSNA
     SSIDDLLGAP QARKGPAARG KKKGRYVDVM AK
//

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