(data stored in ACNUC7421 zone)

SWISSPROT: Q4WD76_ASPFU

ID   Q4WD76_ASPFU            Unreviewed;       636 AA.
AC   Q4WD76;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 89.
DE   SubName: Full=Oxidoreductase (Msc7), putative {ECO:0000313|EMBL:EAL85662.1};
DE            EC=1.2.1.- {ECO:0000313|EMBL:EAL85662.1};
GN   ORFNames=AFUA_6G03770 {ECO:0000313|EMBL:EAL85662.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL85662.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL85662.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL85662.1}.
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DR   EMBL; AAHF01000012; EAL85662.1; -; Genomic_DNA.
DR   RefSeq; XP_747700.1; XM_742607.1.
DR   STRING; 746128.CADAFUBP00009188; -.
DR   EnsemblFungi; EAL85662; EAL85662; AFUA_6G03770.
DR   GeneID; 3505066; -.
DR   KEGG; afm:AFUA_6G03770; -.
DR   EuPathDB; FungiDB:Afu6g03770; -.
DR   HOGENOM; HOG000271512; -.
DR   InParanoid; Q4WD76; -.
DR   OMA; CEDRFGW; -.
DR   OrthoDB; 398557at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4WD76.
DR   SWISS-2DPAGE; Q4WD76.
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003345,
KW   ECO:0000313|EMBL:EAL85662.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT   DOMAIN          92..572
FT                   /note="Aldedh"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        329
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
FT   ACT_SITE        367
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10008"
SQ   SEQUENCE   636 AA;  68782 MW;  2F778650C56998CD CRC64;
     MDSLASLVPP ALAPLIDTLA TNAQLLGVAV ISVAAIYLGY AFVLNSKEAA VTFNIPLPAE
     VRANWTGKKW EDVQGEEKKV LEGQVRGQWS DKLIMSYCPA DGRVLGTGIK PNTADDVNRA
     IQAAKTAQVE WAKTSFADRR KVLRTLLKYV LDHQDEIVAA CCLDSGKTKV DASFGEILVT
     AEKLKWTIDH GEKALTAESR PTNFLMMYKK NVVTYEPLGV VSACVSWNYP FHNFISPVIS
     AIFAGNGIVV KPSEQTAWCT MFFLEIIRGA LSSCGHSRDL VQSVVCLPDV AGALTSHPDI
     SQLTFIGSRP VAHKVCESAA KALTPVTVEL GGKDPAVILD DPRTVSEVSS IASVLMRGVF
     QSAGQNCIGV ERVIALPGIY DKLLDTVAPR IQALRLGSVL LDSRPKDARQ KPNTPDMGAM
     ISPASFDRLE SLIEDAVRQG ARLICGGKRY NHPRHPYGHY FTPTLLADVT PSMRIAQTEL
     FAPVFVLMRA ESVSHAISIA NSTMYALGAS VFGYNQKDVA ACVSQIKAGM VSVNDFASYY
     AVQLPFGGVK GSGYGRFAGE EGLRSVSNIK AVCVDRFPRL MATRIPPRVD YPIQKGDDDK
     QNGTGAWELC KGVVETGYQL TLAGRLGGIL RLLKNM
//

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