(data stored in ACNUC7421 zone)

SWISSPROT: Q4WD73_ASPFU

ID   Q4WD73_ASPFU            Unreviewed;       628 AA.
AC   Q4WD73;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 71.
DE   SubName: Full=C-5 cytosine methyltransferase DmtA {ECO:0000313|EMBL:EAL85665.1};
GN   ORFNames=AFUA_6G03740 {ECO:0000313|EMBL:EAL85665.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL85665.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL85665.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC       ProRule:PRU01016, ECO:0000256|RuleBase:RU000416}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL85665.1}.
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DR   EMBL; AAHF01000012; EAL85665.1; -; Genomic_DNA.
DR   RefSeq; XP_747703.1; XM_742610.1.
DR   STRING; 746128.CADAFUBP00009191; -.
DR   EnsemblFungi; EAL85665; EAL85665; AFUA_6G03740.
DR   GeneID; 3505069; -.
DR   KEGG; afm:AFUA_6G03740; -.
DR   EuPathDB; FungiDB:Afu6g03740; -.
DR   HOGENOM; HOG000201738; -.
DR   InParanoid; Q4WD73; -.
DR   KO; K00558; -.
DR   OMA; SHGSPPC; -.
DR   OrthoDB; 1519639at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0010424; P:DNA methylation on cytosine within a CG sequence; IBA:GO_Central.
DR   GO; GO:0010216; P:maintenance of DNA methylation; IBA:GO_Central.
DR   InterPro; IPR001525; C5_MeTfrase.
DR   InterPro; IPR031303; C5_meth_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases.
DR   Pfam; PF00145; DNA_methylase; 2.
DR   PRINTS; PR00105; C5METTRFRASE.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00675; dcm; 1.
DR   PROSITE; PS00095; C5_MTASE_2; 1.
DR   PROSITE; PS51679; SAM_MT_C5; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4WD73.
DR   SWISS-2DPAGE; Q4WD73.
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01016,
KW   ECO:0000313|EMBL:EAL85665.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01016};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU01016,
KW   ECO:0000313|EMBL:EAL85665.1}.
FT   REGION          1..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..48
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        397
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ   SEQUENCE   628 AA;  70572 MW;  90BD45FAFE04AC56 CRC64;
     MNRPTNDSLH SQEPPQPSEP ICLDDSDDNS SVCDTYSNTD SSVTIDNDPD RSFFLDDEQF
     HPGGGRRTPT PFHIGPQTHQ EIIDLTSGPE LLVTEGDYLT DECFERLLRD WSRPGPAAAP
     LPIREASEWE KRPIDHACVD GIVYKAGHSL ELHNGLFLRI ETVLQDTAEE IFFQGRHLIR
     TWNHKGTYIP KWSNELVWIV NESTEVPLSF VKRFINIRFT NCCHVEQDLQ KRNRPNDLFC
     RLKENLKSSQ AAVEYLSFED SDEGFAIGSM SLRHSWRGET RPFGSADANS QPQSPIIVLD
     ADPVIDLTGI EKEDARVQKK HRKYTFGDGF CGAGGVSCGA SKAGLHIKWA FDKSENAITT
     YRLNFATAVC EACDIFCFLT NKLEELKVDV SHGSPPCQTF SPAHTINSVN DDDNSACIFS
     CADMIKKSRP RVHTMEETSG LFDRHKETFH RVIQDFIEIG YSVRWRILNC MDYGVPQSRR
     RLIIIASGPG EVLPPFPKPT HGLPGSGLSD YTTINQMIAN IPPNAPDHDI EGARSRGLRN
     GTRVPFDPNQ QAKTVTCSGG ENNYHPSGTR GFTNREFACL QTFPLDYRFG AREVRRQIGN
     AVPPALSKAI YREIIKSLQR TDEQELRG
//

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