(data stored in ACNUC7421 zone)

SWISSPROT: FMPR_ASPFU

ID   FMPR_ASPFU              Reviewed;         525 AA.
AC   Q4WD42;
DT   15-FEB-2017, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 68.
DE   RecName: Full=C6 finger transcription factor fmpR {ECO:0000303|PubMed:25582336};
DE   AltName: Full=Fumipyrrole biosynthesis protein R {ECO:0000303|PubMed:25582336};
GN   Name=fmpR {ECO:0000303|PubMed:25582336}; ORFNames=AFUA_6G03430;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
RN   [2]
RP   INDUCTION, FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=25582336; DOI=10.1111/mmi.12926;
RA   Macheleidt J., Scherlach K., Neuwirth T., Schmidt-Heck W., Strassburger M.,
RA   Spraker J., Baccile J.A., Schroeder F.C., Keller N.P., Hertweck C.,
RA   Heinekamp T., Brakhage A.A.;
RT   "Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated
RT   genes reveals the production of the novel natural compound fumipyrrole by
RT   Aspergillus fumigatus.";
RL   Mol. Microbiol. 96:148-162(2015).
CC   -!- FUNCTION: Transcription factor that regulates the gene cluster that
CC       mediates the biosynthesis of fumipyrrole, a brown pigment that is
CC       involved in growth and conidiation (PubMed:25582336).
CC       {ECO:0000269|PubMed:25582336}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- INDUCTION: Expression is induced by the cAMP-dependent protein kinase A
CC       signaling pathway (PubMed:25582336). {ECO:0000269|PubMed:25582336}.
CC   -!- DISRUPTION PHENOTYPE: Leads to reduced growth and sporulation, but does
CC       not affect virulence in infected mice (PubMed:25582336).
CC       {ECO:0000269|PubMed:25582336}.
DR   EMBL; AAHF01000012; EAL85696.1; -; Genomic_DNA.
DR   RefSeq; XP_747734.1; XM_742641.1.
DR   STRING; 746128.CADAFUBP00009220; -.
DR   EnsemblFungi; EAL85696; EAL85696; AFUA_6G03430.
DR   GeneID; 3505181; -.
DR   KEGG; afm:AFUA_6G03430; -.
DR   EuPathDB; FungiDB:Afu6g03430; -.
DR   HOGENOM; HOG000217012; -.
DR   InParanoid; Q4WD42; -.
DR   OMA; YILQAYE; -.
DR   OrthoDB; 1576792at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   Proteomes; UP000002530; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q4WD42.
DR   SWISS-2DPAGE; Q4WD42.
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..525
FT                   /note="C6 finger transcription factor fmpR"
FT                   /id="PRO_0000438868"
FT   DNA_BIND        12..53
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   525 AA;  58058 MW;  B13101FE73A0C7F0 CRC64;
     MMDDKHGRYG ACDRCRGQKL RCVGAGKPIP NSSSRLLRNE IPCDRCRRAK VECYSVRPAP
     RRAASNVKEQ MIATQAASER SSSLAYHTSG PVVSPPNSLV TAASKPHPNS LSFNHPRSDA
     VAAPGGLQTR RQSRDTDSLG DMPSMPHEWM AYLHDHKMDD RQGLGMETPP LIESDLNLSR
     DPAMDSMHEH NMMMELIHQD HQEEWNSGPP ELEAYPDPIV PPNPAPLKAR KLTSPDCDDY
     PYGHTRRSSH TPTQPPEPAG RSCIQELAQF NEMLLRDKCS LEDTSARRGY KDSWLSIGRT
     LHHCQQFFSI LKRIKYSRPD SQLSADRARS QWSSLPEGTS LADGAPTDSP QARRSLARGA
     TPCSSSLARS SSTSSAASTS YLGLSTLLSI LFCYTYILQA YEDILTSILH AVTRPTPTIP
     PTLSGLRIDG FQLDGHHTLQ LECLLHVSYN LLEKIENILF GSAGPEELSN PVKYGILGDK
     LSAGLIDALF EHNETNGLLH CQGKREVAAK RLIREIQAAL KQLDL
//

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