(data stored in ACNUC7421 zone)

SWISSPROT: Q4WCZ7_ASPFU

ID   Q4WCZ7_ASPFU            Unreviewed;       179 AA.
AC   Q4WCZ7;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 58.
DE   RecName: Full=Mitochondrial pyruvate carrier {ECO:0000256|RuleBase:RU363100};
GN   ORFNames=AFUA_6G02970 {ECO:0000313|EMBL:EAL85741.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL85741.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL85741.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Mediates the uptake of pyruvate into mitochondria.
CC       {ECO:0000256|RuleBase:RU363100}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|RuleBase:RU363100}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU363100}.
CC   -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC)
CC       (TC 2.A.105) family. {ECO:0000256|RuleBase:RU363100}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU363100}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL85741.1}.
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DR   EMBL; AAHF01000012; EAL85741.1; -; Genomic_DNA.
DR   RefSeq; XP_747779.1; XM_742686.1.
DR   STRING; 746128.CADAFUBP00009264; -.
DR   EnsemblFungi; EAL85741; EAL85741; AFUA_6G02970.
DR   GeneID; 3505146; -.
DR   KEGG; afm:AFUA_6G02970; -.
DR   EuPathDB; FungiDB:Afu6g02970; -.
DR   HOGENOM; HOG000188910; -.
DR   InParanoid; Q4WCZ7; -.
DR   KO; K22139; -.
DR   OMA; FKTVHFW; -.
DR   OrthoDB; 1422466at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0050833; F:pyruvate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR005336; MPC.
DR   Pfam; PF03650; MPC; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4WCZ7.
DR   SWISS-2DPAGE; Q4WCZ7.
KW   Membrane {ECO:0000256|RuleBase:RU363100};
KW   Mitochondrion {ECO:0000256|RuleBase:RU363100};
KW   Mitochondrion inner membrane {ECO:0000256|RuleBase:RU363100};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Transmembrane {ECO:0000256|RuleBase:RU363100};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363100};
KW   Transport {ECO:0000256|RuleBase:RU363100}.
FT   TRANSMEM        117..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363100"
SQ   SEQUENCE   179 AA;  19803 MW;  46416A8731298427 CRC64;
     MSSSRIGLRF FQNTRAAFRN AYGPFRRPGA QGRRFQTSDA GAASAQQQST FQRLWNSPVG
     IKTVHFWAPV MKWALVIAGI SDFGRPAEKL SLTQNAALMA TGAIWTRWCF IIKPRNILLA
     AVNFFLGCVG VVQVTRIFLY RRSLEGGSTK EALKDFEHEM VDSAKSVVGK AEAAVKKST
//

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