(data stored in ACNUC7421 zone)

SWISSPROT: Q4WCY3_ASPFU

ID   Q4WCY3_ASPFU            Unreviewed;       644 AA.
AC   Q4WCY3;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 106.
DE   SubName: Full=Serine/threonine protein kinase, putative {ECO:0000313|EMBL:EAL85755.1};
GN   ORFNames=AFUA_6G02840 {ECO:0000313|EMBL:EAL85755.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL85755.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL85755.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL85755.1}.
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DR   EMBL; AAHF01000012; EAL85755.1; -; Genomic_DNA.
DR   RefSeq; XP_747793.1; XM_742700.1.
DR   STRING; 746128.CADAFUBP00009276; -.
DR   EnsemblFungi; EAL85755; EAL85755; AFUA_6G02840.
DR   GeneID; 3505334; -.
DR   KEGG; afm:AFUA_6G02840; -.
DR   EuPathDB; FungiDB:Afu6g02840; -.
DR   HOGENOM; HOG000201972; -.
DR   InParanoid; Q4WCY3; -.
DR   OMA; FLDYYYD; -.
DR   OrthoDB; 759391at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0005816; C:spindle pole body; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR   GO; GO:0018105; P:peptidyl-serine phosphorylation; IBA:GO_Central.
DR   InterPro; IPR000961; AGC-kinase_C.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00133; S_TK_X; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
DR   PRODOM; Q4WCY3.
DR   SWISS-2DPAGE; Q4WCY3.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00593399};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Kinase {ECO:0000256|SAAS:SAAS00593820, ECO:0000313|EMBL:EAL85755.1};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00593601};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Serine/threonine-protein kinase {ECO:0000256|SAAS:SAAS00593706,
KW   ECO:0000313|EMBL:EAL85755.1}; Transferase {ECO:0000256|SAAS:SAAS00592725}.
FT   DOMAIN          258..561
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          562..641
FT                   /note="AGC-kinase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51285"
FT   REGION          1..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          109..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          601..621
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        32..58
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..129
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   644 AA;  74146 MW;  8A2223552E1244DC CRC64;
     MMTLDTPRES PERHGLRLPN PPPLLHTRSG NEPFDRPSTP ADNGFTTPAQ TPQGSPSKNR
     MPPGAIDLPN VFEKGMKLTP SSPTKNTFNH YNHPMFAPPK GAMDDFSESV IRQSPGSPTR
     RSNKENTPPS PLKVAKDLGP NPAAAAISRH EPYQQRDLET LQRRQVQMRG LTPEEMEKLQ
     SPRVKRLVNV TQLYFLDHYF DLLSYVHNRQ TRYSQFRAAY PDPPATPIDD YEPALLKYLG
     RERAHLRKRR TRLRQHDFQI LTQVGQGGYG QVYLAQKKDT REVCALKVMS KKLLFKLDEI
     RHILTERDIL TAAKSEWLVK LLYAFQDDEQ IYLAMEYVPG GDFRTLLNNT GVLHNRHARF
     YIAEMFSCID ALHALGYIHR DLKPENFLID STGHVKLTDF GLAAGMLNPG KIESMRVKLE
     EVGNTPVPFG RPMEQRTAAE RRQGYRSLRE RQVNYAKSIV GSPDYMAPEV LKGEEYDFTV
     DYWSLGCMLF EALAGYPPFA GATVDETWQN LKNWQKVLRK PVYEDPNYFL SRRTWGLITK
     LVAAKENRAK SIQEIHAHDY FSEVDFSRLR EQKAPFVPEL DSETDAGYFD DFSNEADMAK
     YKEVHEKQRA LEEMAEREEK MSKGLFVGFT FRYVHHILRA KIYL
//

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