(data stored in ACNUC7421 zone)

SWISSPROT: Q4WCY1_ASPFU

ID   Q4WCY1_ASPFU            Unreviewed;       703 AA.
AC   Q4WCY1;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 89.
DE   SubName: Full=Metalloreductase, putative {ECO:0000313|EMBL:EAL85757.1};
GN   ORFNames=AFUA_6G02820 {ECO:0000313|EMBL:EAL85757.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL85757.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL85757.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL85757.1}.
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DR   EMBL; AAHF01000012; EAL85757.1; -; Genomic_DNA.
DR   RefSeq; XP_747795.1; XM_742702.1.
DR   STRING; 746128.CADAFUBP00009278; -.
DR   EnsemblFungi; EAL85757; EAL85757; AFUA_6G02820.
DR   GeneID; 3505336; -.
DR   KEGG; afm:AFUA_6G02820; -.
DR   EuPathDB; FungiDB:Afu6g02820; -.
DR   HOGENOM; HOG000201994; -.
DR   InParanoid; Q4WCY1; -.
DR   OMA; WVARTMF; -.
DR   OrthoDB; 190356at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0000293; F:ferric-chelate reductase activity; IBA:GO_Central.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IBA:GO_Central.
DR   GO; GO:0015677; P:copper ion import; IBA:GO_Central.
DR   GO; GO:0006826; P:iron ion transport; IBA:GO_Central.
DR   InterPro; IPR013112; FAD-bd_8.
DR   InterPro; IPR017927; FAD-bd_FR_type.
DR   InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR   InterPro; IPR013121; Fe_red_NAD-bd_6.
DR   InterPro; IPR039261; FNR_nucleotide-bd.
DR   InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR   Pfam; PF08022; FAD_binding_8; 1.
DR   Pfam; PF01794; Ferric_reduct; 1.
DR   Pfam; PF08030; NAD_binding_6; 1.
DR   SUPFAM; SSF52343; SSF52343; 1.
DR   SUPFAM; SSF63380; SSF63380; 1.
DR   PROSITE; PS51384; FAD_FR; 1.
PE   4: Predicted;
DR   PRODOM; Q4WCY1.
DR   SWISS-2DPAGE; Q4WCY1.
KW   Membrane {ECO:0000256|SAAS:SAAS00441788, ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS01053954};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00441950, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00441924,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        101..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        142..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        215..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        265..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          300..412
FT                   /note="FAD-binding FR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51384"
FT   REGION          515..545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   703 AA;  78453 MW;  60761F87F5D1E447 CRC64;
     MDGMSMSGMG HMSMGEGVPD VFYLQRMYWA VIGGLHSPFK RYEEPGRSTQ HRLRDSTLTP
     SKPKSFFFSS YATLTAVVRE ASYATLPPIT IRGRSFHFAP LGPIAIILAN LVVVLVFCFY
     KLDTTNKWKW EDVGYRTGFV AISQLPLIFL LAGRQNIIGL FVGLSYERLN WFHRWISRTL
     WLTATIHMGF WFRNWARYDY ITYQLQNDVL TQRGFAAWCI LTFIVISSAA PIRRLSYELF
     VLQHLVTFAG FLAAVWLHAP AEVKAWVWIS IGFLVFDRVA RYVWAAYANL SIFHASKSNP
     HPLWANVATF TPLPGNVTRI TVENPGVRWK PGQHVFLTCH SIVPLQSHPF TITSIPDDGK
     MEFFVRAEKG GTRRFFRYAS KHHLALGSGE VSTAQRPRTV FIDGPYGRIR TLRQFDSVVL
     LAGGMGATFT IPLLRDIVAG WKAECAGNST RRIAATKRIR FVWVIKSRAQ LSWFETQIQS
     VLSDVDECRQ AQPDMIRELE VSIYITCDEK LEQQPPKTAC LQPPSSPTEA PKAIEPRKGE
     FSEKNNRISI QSVSASSSSG QDPASTSGCL PGGGCCCTAA VEDEDEITEH KCTCSGNAPA
     SESSKPIPTA AAETEETRQL KASAQPEPAQ SHHLNLLSGR PQPRIIIRKV LEKAEGESAV
     VVCGPEGLSD DVRRSVVYLS DERAVHKGTG AQGIYLHVEA FGW
//

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