(data stored in ACNUC7421 zone)

SWISSPROT: Q4WCU6_ASPFU

ID   Q4WCU6_ASPFU            Unreviewed;       582 AA.
AC   Q4WCU6;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 93.
DE   SubName: Full=Fumarate hydratase, putative {ECO:0000313|EMBL:EAL85792.1};
DE            EC=4.2.1.2 {ECO:0000313|EMBL:EAL85792.1};
GN   ORFNames=AFUA_6G02470 {ECO:0000313|EMBL:EAL85792.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL85792.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL85792.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL85792.1}.
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DR   EMBL; AAHF01000012; EAL85792.1; -; Genomic_DNA.
DR   RefSeq; XP_747830.1; XM_742737.1.
DR   STRING; 746128.CADAFUBP00009316; -.
DR   SwissPalm; Q4WCU6; -.
DR   PRIDE; Q4WCU6; -.
DR   EnsemblFungi; EAL85792; EAL85792; AFUA_6G02470.
DR   GeneID; 3505081; -.
DR   KEGG; afm:AFUA_6G02470; -.
DR   EuPathDB; FungiDB:Afu6g02470; -.
DR   HOGENOM; HOG000061736; -.
DR   InParanoid; Q4WCU6; -.
DR   KO; K01679; -.
DR   OMA; NDLRWMG; -.
DR   OrthoDB; 1022919at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
DR   GO; GO:0004333; F:fumarate hydratase activity; IBA:GO_Central.
DR   GO; GO:0006106; P:fumarate metabolic process; IBA:GO_Central.
DR   GO; GO:0006108; P:malate metabolic process; IBA:GO_Central.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR   CDD; cd01362; Fumarase_classII; 1.
DR   Gene3D; 1.10.275.10; -; 1.
DR   HAMAP; MF_00743; FumaraseC; 1.
DR   InterPro; IPR005677; Fum_hydII.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR018951; Fumarase_C_C.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR11444; PTHR11444; 1.
DR   Pfam; PF10415; FumaraseC_C; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00979; fumC_II; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4WCU6.
DR   SWISS-2DPAGE; Q4WCU6.
KW   Lyase {ECO:0000313|EMBL:EAL85792.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT   DOMAIN          127..458
FT                   /note="Lyase_1"
FT                   /evidence="ECO:0000259|Pfam:PF00206"
FT   DOMAIN          524..576
FT                   /note="FumaraseC_C"
FT                   /evidence="ECO:0000259|Pfam:PF10415"
SQ   SEQUENCE   582 AA;  63159 MW;  7BCB26CCB7F00348 CRC64;
     MLTSSTNSSR AAVRSMASLT HAATRTTSLN APAAARNALA FAARSPASFS SRRALSFNTR
     SLVQYPRLQS IQSISNKRTF GTTVRMVSVR PSPDGRKAGL TDLRYPLCSQ DFVIAASATR
     TESDAFGEIQ VPADKYWGAQ TQRSLTNFDI NQPQDRMPAP VIKAFGILKA AAAEVNMRYG
     LDPKIGEAIK QAATEVAEGK LMDHFPLVVW QTGSGTQSNM NANEVISNRA IEILGGTMGT
     KKPVHPNDHV NMSASSNDSF PTAMHIAAVL ELENTLLPSL RSLRNALQKK VEKFDKIIKI
     GRTHLQDATP LTLGQEFSGY VAQLDRNIER VEASLPHLRY LAQGGTAVGT GLNTFKGFAE
     GIAEEVTKLT GTEFKTAPNK FEVLAAHDSI VEASGSLNTL ACSLFKIAQD IRYLGSGPRC
     GLGELILPEN EPGSSIMPGK VNPTQCESLT MICSQVMGNH VAATVGGMNG QFELNVFKPL
     MIRNLLHSVR ILSDGMKSFE KHLVEGLEAN EPRINTLLHE SLMLVTCLNP VIGYDMASKV
     AKNAHKKGIT LKESAMELKA LSEEEFDKHV RPELMLSPKE KK
//

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