(data stored in ACNUC7421 zone)

SWISSPROT: Q4WCT6_ASPFU

ID   Q4WCT6_ASPFU            Unreviewed;       169 AA.
AC   Q4WCT6;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 70.
DE   RecName: Full=Actin-related protein 2/3 complex subunit 4 {ECO:0000256|PIRNR:PIRNR039100};
GN   ORFNames=AFUA_6G02370 {ECO:0000313|EMBL:EAL85802.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL85802.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL85802.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Functions as actin-binding component of the Arp2/3 complex
CC       which is involved in regulation of actin polymerization and together
CC       with an activating nucleation-promoting factor (NPF) mediates the
CC       formation of branched actin networks. Seems to contact the mother actin
CC       filament. {ECO:0000256|PIRNR:PIRNR039100}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, actin patch
CC       {ECO:0000256|PIRNR:PIRNR039100}.
CC   -!- SIMILARITY: Belongs to the ARPC4 family.
CC       {ECO:0000256|PIRNR:PIRNR039100}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL85802.1}.
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DR   EMBL; AAHF01000012; EAL85802.1; -; Genomic_DNA.
DR   RefSeq; XP_747840.1; XM_742747.1.
DR   STRING; 746128.CADAFUBP00009326; -.
DR   EnsemblFungi; EAL85802; EAL85802; AFUA_6G02370.
DR   GeneID; 3505261; -.
DR   KEGG; afm:AFUA_6G02370; -.
DR   EuPathDB; FungiDB:Afu6g02370; -.
DR   HOGENOM; HOG000202303; -.
DR   InParanoid; Q4WCT6; -.
DR   KO; K05755; -.
DR   OMA; RFMMQRA; -.
DR   OrthoDB; 1351067at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.
DR   GO; GO:0005885; C:Arp2/3 protein complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0030041; P:actin filament polymerization; IEA:UniProtKB-UniRule.
DR   GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1460.20; -; 1.
DR   InterPro; IPR034666; ARPC2/4.
DR   InterPro; IPR008384; ARPC4.
DR   PANTHER; PTHR22629; PTHR22629; 1.
DR   Pfam; PF05856; ARPC4; 1.
DR   PIRSF; PIRSF039100; ARPC4; 1.
DR   SUPFAM; SSF69645; SSF69645; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4WCT6.
DR   SWISS-2DPAGE; Q4WCT6.
KW   Actin-binding {ECO:0000256|PIRNR:PIRNR039100};
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR039100};
KW   Cytoskeleton {ECO:0000256|PIRNR:PIRNR039100};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530}.
SQ   SEQUENCE   169 AA;  19570 MW;  D4AFC9BD77017D5B CRC64;
     MSQSLRPYLQ CVRSSLTAAL AISNFASQTS ERHNVPEIEA QSSPELLLNP LTISRNENEK
     VLIEPSVNSV RVSIRIKQAD EIEHILVHKF TRFLTQRAES FFILRRKPVK GYDISFLITN
     FHTEAMLKHK LVDFIIQFME EVDKEISEMK LFLNARARFV AESFLTPFD
//

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