(data stored in ACNUC7421 zone)

SWISSPROT: Q4WCS1_ASPFU

ID   Q4WCS1_ASPFU            Unreviewed;       636 AA.
AC   Q4WCS1;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 71.
DE   SubName: Full=MFS toxin efflux pump, putative {ECO:0000313|EMBL:EAL85817.1};
GN   ORFNames=AFUA_6G02220 {ECO:0000313|EMBL:EAL85817.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL85817.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL85817.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL85817.1}.
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DR   EMBL; AAHF01000012; EAL85817.1; -; Genomic_DNA.
DR   RefSeq; XP_747855.1; XM_742762.1.
DR   STRING; 746128.CADAFUBP00009339; -.
DR   EnsemblFungi; EAL85817; EAL85817; AFUA_6G02220.
DR   GeneID; 3505283; -.
DR   KEGG; afm:AFUA_6G02220; -.
DR   EuPathDB; FungiDB:Afu6g02220; -.
DR   HOGENOM; HOG000048649; -.
DR   InParanoid; Q4WCS1; -.
DR   OrthoDB; 627633at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR001411; Tet-R_TetB/Drug-R_transptr.
DR   PANTHER; PTHR23501; PTHR23501; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   4: Predicted;
DR   PRODOM; Q4WCS1.
DR   SWISS-2DPAGE; Q4WCS1.
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        88..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        126..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        156..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        213..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        285..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        353..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          91..636
FT                   /note="MFS"
FT                   /evidence="ECO:0000259|PROSITE:PS50850"
FT   REGION          1..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..29
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   636 AA;  70468 MW;  C4A6BE2D94C5C938 CRC64;
     MENTASGHSP HSPGANSSQT KLTSEPHAPG RRQSSDKEST LVESSPGLEY PQSPVPERRS
     ESQAMGMEYS EGHGNEKQEP EHLKSWKLGF VMASISLVIF CMSLDNTILA TAIPKITDQF
     NSLDDVGWYG SSYLLTTCSL VLPYGKLYTF YSTKWVYLTA IAIFEIGSLI CGVAPNSVAL
     IIGRAVAGLG AAGLFTGSIL IIAQSVPLQK RPIYTGVLGG MYGISSVAGP LMGGAFTDHV
     TWRWCFYINL PIGGVTWLFV LLFFKAPKSY KDNSGLKDQV SRLDLPGLFV FLPAIISMLL
     ALQWGGTKYN WGNARIIALF VVFGVLIVIF AARQHWAQEN ATVPPRILKN RNVWGAAFYS
     FSVSAAFMLF VYYVPSNLVP SHQRRLGDQI WYHEPAHAAW NSSDVPRLWV PGFGNRLLHP
     LHADLFGDHD DRGRSAIDTE GRLRPSCLDR VPGPDWDWDW RRTSASNDCG ADCGSGHGCP
     QRNGHRDVHP ISRRRAVRFS RAERIPEPTV QKPGHRGAEC QCCTSRRDWC HYAATRCFRG
     CATGSPRCLQ QRHHRVVLRC CCHGGNFDHR RPSSPVALRE GKEDRSTPCL DLIAARGYRL
     FIASKLIAEL MQALAWGRDT CLQGGCLSLS FRWPVA
//

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