(data stored in ACNUC7421 zone)

SWISSPROT: Q4WCQ5_ASPFU

ID   Q4WCQ5_ASPFU            Unreviewed;      2076 AA.
AC   Q4WCQ5;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 83.
DE   SubName: Full=tRNA-splicing endonuclease, putative {ECO:0000313|EMBL:EAL85833.1};
GN   ORFNames=AFUA_6G02060 {ECO:0000313|EMBL:EAL85833.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL85833.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL85833.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL85833.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAHF01000012; EAL85833.1; -; Genomic_DNA.
DR   RefSeq; XP_747871.1; XM_742778.1.
DR   STRING; 746128.CADAFUBP00009357; -.
DR   EnsemblFungi; EAL85833; EAL85833; AFUA_6G02060.
DR   GeneID; 3505311; -.
DR   KEGG; afm:AFUA_6G02060; -.
DR   EuPathDB; FungiDB:Afu6g02060; -.
DR   HOGENOM; HOG000202533; -.
DR   InParanoid; Q4WCQ5; -.
DR   KO; K10706; -.
DR   OMA; LVQGEFW; -.
DR   OrthoDB; 62494at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0016604; C:nuclear body; IBA:GO_Central.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0001147; F:transcription termination site sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR   InterPro; IPR041679; DNA2/NAM7-like_AAA.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR024481; Helicase_Sen1_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001878; Znf_CCHC.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF12726; SEN1_N; 1.
DR   SMART; SM00343; ZnF_C2HC; 3.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF57756; SSF57756; 1.
DR   PROSITE; PS50158; ZF_CCHC; 2.
PE   4: Predicted;
DR   PRODOM; Q4WCQ5.
DR   SWISS-2DPAGE; Q4WCQ5.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Endonuclease {ECO:0000313|EMBL:EAL85833.1};
KW   Hydrolase {ECO:0000313|EMBL:EAL85833.1};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Nuclease {ECO:0000313|EMBL:EAL85833.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT   DOMAIN          1924..1937
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50158"
FT   DOMAIN          1941..1957
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50158"
FT   REGION          1011..1041
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1829..1891
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1965..2076
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          956..978
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1476..1503
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1840..1876
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1965..1993
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2008..2038
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2076 AA;  232625 MW;  6B64A057B3956596 CRC64;
     MDFMDIVGEL RALPDNVHIL CPRQHDDDHG RYDDPNEIDD AGKSAAELVA EASSRREKFL
     SCMRILAYNQ EGVEELQTWI WRKLDDALEK CDLCIKQYYT GKIWLMEQLK ENYDDEDIEK
     FARMLDDWDV KRITKNLATA TAKLKEVPPQ EIGLHVLDRA SLLSIFESLS CEAMLRNDTL
     LQEHFDEPFR LIQTKRSLKV SDYVPAVTRF LFDSNQSRSF WAIHSWMRYS RPPTALEFDW
     AIKEGLLDML KTASQQPPQI AVIQRLWRGM QLVVKRLDKD QITHHLRALE IDPCRLSVEH
     LGIQSPGLRF LLNTIQIFLE KAPGDFWDAM QTISPQAIIE LVFYNPQLEA FLMQISEGEP
     YEKSALKDML SWVEPFMSSL KGAHQPSACR SLVYQLLDRL QNPRFPDLAR YHCFYVGLAS
     LLQTLRSFTD NESSRGSVAR IVLSETMGVV SANIETILNP PKFAVEQRRQ EEISSLCMDV
     IRNTLALECQ SLKSDYEVIL RQNLLQHGVS TYSASIWEAV VRNLHEDNRA LSTSALLGIL
     PLVGLETFPT KGESSPEKTH FNLIYGHLTR LSCQIIERLA DFKPEHLNEL LKSQDTSSAL
     ISALFAADLD TYQAAVDLIK NMSGQSARRD AISHLLQSFF ITTMYGLSWS FRRISNMKTF
     ASAPRMLHTG TDIIDILCDS QTGMLRTRKL ADRREILSLQ KLWEYLWQAL STIFDETEAW
     HLRGNDKAVM LEFCRDTIQF ADLLFDQYGV FLSAVVDADP SQEASARENF LKSPTTTMSA
     MVKWLRLKDE YLATTLVGLV AKLLRRLGEL SVTTVKDDAL SFIEGVAVKS TIKTILTLRE
     KAELVRALEA YYKKPVVTAS TASLKKQSMI TAFAKPAEVS ATPSPAKTTS EDEFDEDNVP
     DDVLMQLSRS VELNKERLVA EARRRGDKAA KALPAIPKPS AAPLKPNLTV QSFREKREKE
     KEAKRKRDLA ELARLKKNLP ARGVGEQTAE QGSGLSGIGV KGKVHTTVEE SMMVSSDSES
     ESESEDELDK ELFGPKARSQ PDAIKAYEES KKLSLKQQGP VKKIKQVRSA KDMRARLAPD
     LSSLHRTILA WDFFANGDLP PNSGRTDYSL VSNTFKDPLE YQKTFEPLLI LEAWQGFNST
     KEEGTFRPFE IKVATRLSVD SFVEVSTVLP SLEVKDLGLS EADIVLLSKS SRPTSDSSAP
     HCFARVAGIN KKRGTVEISY RVNPGSPFIN SLGPGVTIWG AKITSLTPLE REYGALMALQ
     YYDLCEEVIK AKPSPILHYS DASLKPIADN YNVNPAQAKA IKSALDNDAF TLIQGPPGSG
     KTKTIVALVG ALLSNVLGDQ GVTISRPTGV TNPRVPGRTT TSKKLLVCAP SNAAVDELVM
     RFKEGVKTIH GRHEKLNVIR LGRSDAINTN VLDVTLDELV NARLSQNPRK DSGERDLQTI
     YMEHKAADTA FKETRAKIDQ CRAQGLPVPE ELEREFDLLK KKKTQLSQEI DTARDKNHSA
     ARDADLNRRR IQQEIINNAH VICATLSGSG HEMFQNLSIE FETVVIDEAA QSIELSALIP
     LKYGCSKCIL VGDPKQLPPT VLSKVASKFQ YEQSLFVRMQ ANHPKDVHLL DTQYRMHPEI
     SVYPSAAFYD GKLKDGPNMA KLRARPWHQS ELLGPYRFFD VQGLHQNTTK GHSLINLAEL
     RVAMQLYERL ITDFREYDFS GKIGIITPYK GQLRELKTQF AARYGNAIFN MVDFNTTDAF
     QGRESEVIIF SCVRASNKGI GFLADIRRMN VGLTRAKSSL WVLGNSQSLV QGEFWNGLIK
     DARRRNVYTD GDILGILQRP QFTGYKNIDM MDAESPNPTA SLKAAGSEPA SRPTSASFDR
     PTSESSISTS VSRRGTPTEP PPDLPSGGPN GLDDTRTCGY CGSFAHMTHN CDNIDAKEAS
     RGTCYRCGRS GHTRVVCMAE RCLQCGEFGH DAQRCQSARE LSKKEKSRIA REEHQHAQMK
     KQRTERQRQK QLGGHDPKVP VLQVSSDPPP REDKKPEKRK PDQSNAPGKR KRTGSESPDT
     SKVSKPRSSD SVPNPPKGPR RKIDANVPTN TAVGLD
//

If you have problems or comments...

PBIL Back to PBIL home page