(data stored in ACNUC7421 zone)

SWISSPROT: Q4WNH3_ASPFU

ID   Q4WNH3_ASPFU            Unreviewed;       455 AA.
AC   Q4WNH3;
DT   05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2005, sequence version 1.
DT   11-DEC-2019, entry version 89.
DE   RecName: Full=Isocitrate dehydrogenase [NAD] subunit, mitochondrial {ECO:0000256|RuleBase:RU361266};
GN   ORFNames=AFUA_6G06370 {ECO:0000313|EMBL:EAL88491.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL88491.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EAL88491.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|RuleBase:RU361266}.
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|RuleBase:RU361266}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAL88491.1}.
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DR   EMBL; AAHF01000006; EAL88491.1; -; Genomic_DNA.
DR   RefSeq; XP_750529.1; XM_745436.1.
DR   STRING; 746128.CADAFUBP00007037; -.
DR   EnsemblFungi; EAL88491; EAL88491; AFUA_6G06370.
DR   GeneID; 3508845; -.
DR   KEGG; afm:AFUA_6G06370; -.
DR   EuPathDB; FungiDB:Afu6g06370; -.
DR   HOGENOM; HOG000021113; -.
DR   InParanoid; Q4WNH3; -.
DR   KO; K00030; -.
DR   OMA; TSMQLVA; -.
DR   OrthoDB; 868374at2759; -.
DR   Proteomes; UP000002530; Chromosome 6.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IBA:GO_Central.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051287; F:NAD binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006102; P:isocitrate metabolic process; IBA:GO_Central.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR   InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR   InterPro; IPR004434; Isocitrate_DH_NAD.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   Pfam; PF00180; Iso_dh; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   TIGRFAMs; TIGR00175; mito_nad_idh; 1.
DR   PROSITE; PS00470; IDH_IMDH; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q4WNH3.
DR   SWISS-2DPAGE; Q4WNH3.
KW   Mitochondrion {ECO:0000256|RuleBase:RU361266};
KW   Oxidoreductase {ECO:0000313|EMBL:EAL88491.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW   Transit peptide {ECO:0000256|RuleBase:RU361266};
KW   Tricarboxylic acid cycle {ECO:0000256|RuleBase:RU361266}.
FT   DOMAIN          114..447
FT                   /note="Iso_dh"
FT                   /evidence="ECO:0000259|SMART:SM01329"
SQ   SEQUENCE   455 AA;  49745 MW;  800FB6121B2ED8C8 CRC64;
     MFSLRTAQPA QVSKTLHQID CVTRGRAFSH FLSHFSLLRP AAASQQLSHS QCLDVMFLCI
     KANVLLLCRL SYAAQLVQAL SSTPRSQQDL LLACSLTSSS PRSMAESTPL LSFQVPMAHP
     KPCPECDGIG AEVAESVKTI FKADNVPIEW EQVDVSGVDT GNKHSEELFK ESIASLRRNK
     LGLKGILFTP VERSGHQSFN VALRQELDIF ASIVLIKNIP GYKTRHENVD LCIIRENTEG
     EYSGLEHQSV QGVVESLKII TRAKSERIAK FAFGFALANN RKKVTCIHKA NIMKLADGLF
     RSTFHKVAEM YPTLEVNDMI VDNASMQAVS RPQQFDVMVM PNLYGGILSN VGAALVGGPG
     VVPGCNMGRD VAVFEPGCRH VGLDIKGKDQ ANPSAMILSG SMLLRHLGLD DHANRISKAV
     YDVIGEGKTR TRDMGGQATT HEFTRAVLDK MEAAL
//

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