(data stored in ACNUC7421 zone)

SWISSPROT: A4AT78_MARSH

ID   A4AT78_MARSH            Unreviewed;       297 AA.
AC   A4AT78;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 70.
DE   RecName: Full=Tyrosine recombinase XerC {ECO:0000256|HAMAP-Rule:MF_01808};
GN   Name=xerC {ECO:0000256|HAMAP-Rule:MF_01808};
GN   OrderedLocusNames=FB2170_16226 {ECO:0000313|EMBL:EAR00648.1};
OS   Maribacter sp. (strain HTCC2170 / KCCM 42371).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Maribacter.
OX   NCBI_TaxID=313603 {ECO:0000313|EMBL:EAR00648.1, ECO:0000313|Proteomes:UP000001602};
RN   [1] {ECO:0000313|EMBL:EAR00648.1, ECO:0000313|Proteomes:UP000001602}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTCC2170 / KCCM 42371 {ECO:0000313|Proteomes:UP000001602};
RX   PubMed=21037013; DOI=10.1128/JB.01207-10;
RA   Oh H.M., Kang I., Yang S.J., Jang Y., Vergin K.L., Giovannoni S.J.,
RA   Cho J.C.;
RT   "Complete genome sequence of strain HTCC2170, a novel member of the
RT   genus Maribacter in the family Flavobacteriaceae.";
RL   J. Bacteriol. 193:303-304(2011).
CC   -!- FUNCTION: Site-specific tyrosine recombinase, which acts by
CC       catalyzing the cutting and rejoining of the recombining DNA
CC       molecules. The XerC-XerD complex is essential to convert dimers of
CC       the bacterial chromosome into monomers to permit their segregation
CC       at cell division. It also contributes to the segregational
CC       stability of plasmids. {ECO:0000256|HAMAP-Rule:MF_01808}.
CC   -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two
CC       molecules of XerC and two molecules of XerD. {ECO:0000256|HAMAP-
CC       Rule:MF_01808, ECO:0000256|SAAS:SAAS00608017}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01808,
CC       ECO:0000256|SAAS:SAAS00019473}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. XerC
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_01808,
CC       ECO:0000256|SAAS:SAAS00608022}.
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DR   EMBL; CP002157; EAR00648.1; -; Genomic_DNA.
DR   RefSeq; WP_013304451.1; NC_014472.1.
DR   STRING; 313603.FB2170_16226; -.
DR   EnsemblBacteria; EAR00648; EAR00648; FB2170_16226.
DR   KEGG; fbc:FB2170_16226; -.
DR   eggNOG; ENOG4105C13; Bacteria.
DR   eggNOG; COG4974; LUCA.
DR   HOGENOM; HOG000045294; -.
DR   KO; K03733; -.
DR   OMA; FASHMLE; -.
DR   OrthoDB; 745068at2; -.
DR   BioCyc; MSP313603:G1GNS-24-MONOMER; -.
DR   Proteomes; UP000001602; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   HAMAP; MF_01808; Recomb_XerC_XerD; 1.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD.
DR   Pfam; PF02899; Phage_int_SAM_1; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4AT78.
DR   SWISS-2DPAGE; A4AT78.
KW   Cell cycle {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00608023};
KW   Cell division {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00608024};
KW   Chromosome partition {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00608018};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001602};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00094312};
KW   DNA integration {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00298355};
KW   DNA recombination {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00019433};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01808,
KW   ECO:0000256|SAAS:SAAS00424103};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001602}.
FT   DOMAIN        3     85       Integrase_SAM-like_N. {ECO:0000259|Pfam:
FT                                PF02899}.
FT   DOMAIN      115    278       Phage_integrase. {ECO:0000259|Pfam:
FT                                PF00589}.
FT   ACT_SITE    146    146       {ECO:0000256|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    170    170       {ECO:0000256|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    240    240       {ECO:0000256|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    243    243       {ECO:0000256|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    266    266       {ECO:0000256|HAMAP-Rule:MF_01808}.
FT   ACT_SITE    275    275       O-(3'-phospho-DNA)-tyrosine intermediate.
FT                                {ECO:0000256|HAMAP-Rule:MF_01808}.
SQ   SEQUENCE   297 AA;  34482 MW;  CB747BDE6AC36D0D CRC64;
     MSVQSFTSYL LLEKNYSKHT VNAYEKDIQS FIDFCDKELK LESINNVEYN IIRNWIVTLV
     NTGISNRSVN RKIASLKAYY KFLQRVGSIN INPLAKHKAL KTSKKIEVPF SEEEMQRILL
     QLPFEDDFEG SRDKLIIELL YTTGIRRSEL INLRTNSVDL NQRSMKVLGK RNKERIVPLL
     LPTIDLFEAY FRYRKELENI THDEYIFLTI SGNKIYETLV YRIIKGYFSK VSSKVKRSPH
     ILRHTFATHL LNKGADLNSV KELLGHSSLA STQVYTHNSI AELKKVHSSA HPRGKKL
//

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