(data stored in ACNUC7421 zone)

SWISSPROT: A4ATL6_MARSH

ID   A4ATL6_MARSH            Unreviewed;       450 AA.
AC   A4ATL6;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 89.
DE   RecName: Full=UDP-N-acetylmuramate--L-alanine ligase {ECO:0000256|HAMAP-Rule:MF_00046, ECO:0000256|SAAS:SAAS01090471};
DE            EC=6.3.2.8 {ECO:0000256|HAMAP-Rule:MF_00046, ECO:0000256|SAAS:SAAS01090477};
DE   AltName: Full=UDP-N-acetylmuramoyl-L-alanine synthetase {ECO:0000256|HAMAP-Rule:MF_00046};
GN   Name=murC {ECO:0000256|HAMAP-Rule:MF_00046};
GN   OrderedLocusNames=FB2170_16916 {ECO:0000313|EMBL:EAR00786.1};
OS   Maribacter sp. (strain HTCC2170 / KCCM 42371).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Maribacter.
OX   NCBI_TaxID=313603 {ECO:0000313|EMBL:EAR00786.1, ECO:0000313|Proteomes:UP000001602};
RN   [1] {ECO:0000313|EMBL:EAR00786.1, ECO:0000313|Proteomes:UP000001602}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTCC2170 / KCCM 42371 {ECO:0000313|Proteomes:UP000001602};
RX   PubMed=21037013; DOI=10.1128/JB.01207-10;
RA   Oh H.M., Kang I., Yang S.J., Jang Y., Vergin K.L., Giovannoni S.J.,
RA   Cho J.C.;
RT   "Complete genome sequence of strain HTCC2170, a novel member of the
RT   genus Maribacter in the family Flavobacteriaceae.";
RL   J. Bacteriol. 193:303-304(2011).
CC   -!- FUNCTION: Cell wall formation. {ECO:0000256|HAMAP-Rule:MF_00046,
CC       ECO:0000256|SAAS:SAAS01090476}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP +
CC         H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine;
CC         Xref=Rhea:RHEA:23372, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57972, ChEBI:CHEBI:70757,
CC         ChEBI:CHEBI:83898, ChEBI:CHEBI:456216; EC=6.3.2.8;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00046,
CC         ECO:0000256|SAAS:SAAS01124320};
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00046, ECO:0000256|SAAS:SAAS00085119}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00046,
CC       ECO:0000256|SAAS:SAAS00085149}.
CC   -!- SIMILARITY: Belongs to the MurCDEF family. {ECO:0000256|HAMAP-
CC       Rule:MF_00046, ECO:0000256|SAAS:SAAS01090475}.
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DR   EMBL; CP002157; EAR00786.1; -; Genomic_DNA.
DR   RefSeq; WP_013304589.1; NC_014472.1.
DR   STRING; 313603.FB2170_16916; -.
DR   EnsemblBacteria; EAR00786; EAR00786; FB2170_16916.
DR   KEGG; fbc:FB2170_16916; -.
DR   eggNOG; ENOG4105DFU; Bacteria.
DR   eggNOG; COG0773; LUCA.
DR   HOGENOM; HOG000256031; -.
DR   KO; K01924; -.
DR   OMA; LTMGAGD; -.
DR   OrthoDB; 307881at2; -.
DR   BioCyc; MSP313603:G1GNS-161-MONOMER; -.
DR   UniPathway; UPA00219; -.
DR   Proteomes; UP000001602; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008763; F:UDP-N-acetylmuramate-L-alanine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1190.10; -; 1.
DR   Gene3D; 3.90.190.20; -; 1.
DR   HAMAP; MF_00046; MurC; 1.
DR   InterPro; IPR036565; Mur-like_cat_sf.
DR   InterPro; IPR004101; Mur_ligase_C.
DR   InterPro; IPR036615; Mur_ligase_C_dom_sf.
DR   InterPro; IPR013221; Mur_ligase_cen.
DR   InterPro; IPR000713; Mur_ligase_N.
DR   InterPro; IPR005758; UDP-N-AcMur_Ala_ligase_murC.
DR   Pfam; PF01225; Mur_ligase; 1.
DR   Pfam; PF02875; Mur_ligase_C; 1.
DR   Pfam; PF08245; Mur_ligase_M; 1.
DR   SUPFAM; SSF53244; SSF53244; 1.
DR   SUPFAM; SSF53623; SSF53623; 1.
DR   TIGRFAMs; TIGR01082; murC; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4ATL6.
DR   SWISS-2DPAGE; A4ATL6.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00046,
KW   ECO:0000256|SAAS:SAAS00459234};
KW   Cell cycle {ECO:0000256|HAMAP-Rule:MF_00046,
KW   ECO:0000256|SAAS:SAAS00459266};
KW   Cell division {ECO:0000256|HAMAP-Rule:MF_00046,
KW   ECO:0000256|SAAS:SAAS00459376};
KW   Cell shape {ECO:0000256|HAMAP-Rule:MF_00046,
KW   ECO:0000256|SAAS:SAAS00459316};
KW   Cell wall biogenesis/degradation {ECO:0000256|HAMAP-Rule:MF_00046,
KW   ECO:0000256|SAAS:SAAS00459280};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001602};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00046,
KW   ECO:0000256|SAAS:SAAS00459252};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00046,
KW   ECO:0000256|SAAS:SAAS00459220, ECO:0000313|EMBL:EAR00786.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00046,
KW   ECO:0000256|SAAS:SAAS00459312};
KW   Peptidoglycan synthesis {ECO:0000256|HAMAP-Rule:MF_00046,
KW   ECO:0000256|SAAS:SAAS00459348};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001602};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM      6     26       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        9    110       Mur_ligase. {ECO:0000259|Pfam:PF01225}.
FT   DOMAIN      117    286       Mur_ligase_M. {ECO:0000259|Pfam:PF08245}.
FT   DOMAIN      306    393       Mur_ligase_C. {ECO:0000259|Pfam:PF02875}.
FT   NP_BIND     119    125       ATP. {ECO:0000256|HAMAP-Rule:MF_00046}.
SQ   SEQUENCE   450 AA;  50559 MW;  A8E2716CA83D8C73 CRC64;
     MDLKKINSVY FIGIGGIGMS ALARYFRFIE KNVAGYDKTE TPLTQELEAL GIDIHYNDDL
     KAIDDCYKNT EDTLIIYTPA VPKTHSEYQY FLSKGFEVHK RSEVLGMITK DTFCFAVAGT
     HGKTTTSSIL AHLLNETGTP FTAFLGGISE DFNSNFLFRG SDYSVVEADE FDRSFLRLYP
     DVACITSMDA DHLDIYGNSE ELTKSFNDFV GKINPDGKLF VRNGLPLDGI TYGIEDDSDY
     CIRNLKIEHG AYIFDLKTPK TTLSGVKFNK PGKHNLLNGL VAFAMAIEAG SPPYRLAEAL
     GTFKGVQRRF SYKIKEDDFV FIDDYAHHPT EINAVYDAIA EMHPDKNVLA VFQPHLFSRT
     RDFGDDFAES LSKFDSILLL EIYPAREQPI EGITSKWLMK KIDNDNKKLI GKSNLIQEIK
     AQSPDVLVTM GAGDIGLEVS RIRKEFEYAN
//

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