(data stored in ACNUC7421 zone)

SWISSPROT: A4ATQ8_MARSH

ID   A4ATQ8_MARSH            Unreviewed;       317 AA.
AC   A4ATQ8;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 58.
DE   RecName: Full=Methylenetetrahydrofolate reductase {ECO:0000256|RuleBase:RU003862};
DE            EC=1.5.1.20 {ECO:0000256|RuleBase:RU003862};
GN   OrderedLocusNames=FB2170_17126 {ECO:0000313|EMBL:EAR00828.1};
OS   Maribacter sp. (strain HTCC2170 / KCCM 42371).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Maribacter.
OX   NCBI_TaxID=313603 {ECO:0000313|EMBL:EAR00828.1, ECO:0000313|Proteomes:UP000001602};
RN   [1] {ECO:0000313|EMBL:EAR00828.1, ECO:0000313|Proteomes:UP000001602}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTCC2170 / KCCM 42371 {ECO:0000313|Proteomes:UP000001602};
RX   PubMed=21037013; DOI=10.1128/JB.01207-10;
RA   Oh H.M., Kang I., Yang S.J., Jang Y., Vergin K.L., Giovannoni S.J.,
RA   Cho J.C.;
RT   "Complete genome sequence of strain HTCC2170, a novel member of the
RT   genus Maribacter in the family Flavobacteriaceae.";
RL   J. Bacteriol. 193:303-304(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-
CC         5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH;
CC         Xref=Rhea:RHEA:19821, ChEBI:CHEBI:15378, ChEBI:CHEBI:15636,
CC         ChEBI:CHEBI:18608, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945;
CC         EC=1.5.1.20; Evidence={ECO:0000256|RuleBase:RU003862};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|RuleBase:RU003862};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|RuleBase:RU003862}.
CC   -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase
CC       family. {ECO:0000256|RuleBase:RU003862}.
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DR   EMBL; CP002157; EAR00828.1; -; Genomic_DNA.
DR   RefSeq; WP_013304631.1; NC_014472.1.
DR   STRING; 313603.FB2170_17126; -.
DR   EnsemblBacteria; EAR00828; EAR00828; FB2170_17126.
DR   KEGG; fbc:FB2170_17126; -.
DR   eggNOG; ENOG4105SYT; Bacteria.
DR   eggNOG; COG0685; LUCA.
DR   HOGENOM; HOG000246233; -.
DR   KO; K00297; -.
DR   OMA; FIRAETG; -.
DR   OrthoDB; 1425269at2; -.
DR   BioCyc; MSP313603:G1GNS-202-MONOMER; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000001602; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:InterPro.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00537; MTHFR; 1.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR003171; Mehydrof_redctse.
DR   InterPro; IPR004620; MTHF_reductase_bac.
DR   Pfam; PF02219; MTHFR; 1.
DR   SUPFAM; SSF51730; SSF51730; 1.
DR   TIGRFAMs; TIGR00676; fadh2; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4ATQ8.
DR   SWISS-2DPAGE; A4ATQ8.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001602};
KW   FAD {ECO:0000256|RuleBase:RU003862};
KW   Flavoprotein {ECO:0000256|RuleBase:RU003862};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003862};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001602}.
SQ   SEQUENCE   317 AA;  35602 MW;  534AD5C04D068454 CRC64;
     MKITDHILNA KGKTLFSFEI VPPVKGKNIQ ELYNNIDPLM EFKPPFIDVT TSREEYVYIN
     KSGLLDKKLT RRRPGTVGIC ASIQHKYKVD TVPHILCGGF TKEETEYVLV DCHYLGIQNV
     MALRGDARSE QKYFEATKGG HAFASELVGQ IQNLNCGKYL HEEIESDNCA DFCIGVAGYP
     EKHLEAPSLQ SDLKRLKEKV DAGADYVVTQ MFFDNQKYFE FVDAAKEIGI NVPIIPGIKP
     IAVKRHLQLL PQVFRIDLPQ DLIDAVDDCK DNKAVRQVGV DWAIQQSKEL KAAGVPVLHY
     YSMGKSDNIH AIAKGVF
//

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