(data stored in ACNUC7421 zone)

SWISSPROT: A4DA81_ASPFU

ID   A4DA81_ASPFU            Unreviewed;       330 AA.
AC   A4DA81;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   11-DEC-2019, entry version 61.
DE   RecName: Full=Cytochrome c heme lyase {ECO:0000256|RuleBase:RU363130};
DE            EC=4.4.1.17 {ECO:0000256|RuleBase:RU363130};
GN   ORFNames=AFUA_4G04600 {ECO:0000313|EMBL:EBA27197.1};
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879 {ECO:0000313|EMBL:EBA27197.1, ECO:0000313|Proteomes:UP000002530};
RN   [1] {ECO:0000313|EMBL:EBA27197.1, ECO:0000313|Proteomes:UP000002530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC   {ECO:0000313|Proteomes:UP000002530};
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA   Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA   Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA   Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA   Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA   Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA   Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA   Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA   Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA   Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA   Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA   Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA   Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA   Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Links covalently the heme group to the apoprotein of
CC       cytochrome c. {ECO:0000256|RuleBase:RU363130}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=holo-[cytochrome c] = apo-[cytochrome c] + heme b;
CC         Xref=Rhea:RHEA:22648, Rhea:RHEA-COMP:10725, Rhea:RHEA-COMP:10726,
CC         ChEBI:CHEBI:29950, ChEBI:CHEBI:60344, ChEBI:CHEBI:83739; EC=4.4.1.17;
CC         Evidence={ECO:0000256|RuleBase:RU363130};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|RuleBase:RU363130}.
CC   -!- SIMILARITY: Belongs to the cytochrome c-type heme lyase family.
CC       {ECO:0000256|RuleBase:RU363130}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EBA27197.1}.
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DR   EMBL; AAHF01000016; EBA27197.1; -; Genomic_DNA.
DR   RefSeq; XP_001481551.1; XM_001481501.1.
DR   STRING; 746128.CADAFUBP00009562; -.
DR   EnsemblFungi; EBA27197; EBA27197; AFUA_4G04600.
DR   GeneID; 5077103; -.
DR   KEGG; afm:AFUA_4G04600; -.
DR   EuPathDB; FungiDB:Afu4g04600; -.
DR   HOGENOM; HOG000170352; -.
DR   InParanoid; A4DA81; -.
DR   KO; K01764; -.
DR   OMA; YPSKFGT; -.
DR   OrthoDB; 1282808at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0004408; F:holocytochrome-c synthase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0018063; P:cytochrome c-heme linkage; IBA:GO_Central.
DR   InterPro; IPR000511; Cyt_C/C1_haem_lyase.
DR   PANTHER; PTHR12743; PTHR12743; 1.
DR   Pfam; PF01265; Cyto_heme_lyase; 1.
DR   PROSITE; PS00822; CYTO_HEME_LYASE_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; A4DA81.
DR   SWISS-2DPAGE; A4DA81.
KW   Heme {ECO:0000256|RuleBase:RU363130}; Iron {ECO:0000256|RuleBase:RU363130};
KW   Lyase {ECO:0000256|RuleBase:RU363130, ECO:0000313|EMBL:EBA27197.1};
KW   Membrane {ECO:0000256|RuleBase:RU363130};
KW   Metal-binding {ECO:0000256|RuleBase:RU363130};
KW   Mitochondrion {ECO:0000256|RuleBase:RU363130};
KW   Mitochondrion inner membrane {ECO:0000256|RuleBase:RU363130};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT   REGION          1..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          104..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..59
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..88
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   330 AA;  36471 MW;  B61791E888A0207C CRC64;
     MGWFWADPQA KPTPVAPNPL ASSDASPPPG CPMHASNAPP ALSSLSARSD TSSSCPVRSP
     DSPFYVRPKT TVTDSPQPPA PETKSALSKL NPLNYMFSSI SQERAPNQTV DLPVEREPSS
     IPRGDADGNW EYPSPQQMYN AMLRKGYTDT PQDAVEAMVA VHNFLNEGAW AEIVGWERLF
     AKGLGQAWEK CRKGEQGIAR EAMKQEMTGN VDPACEPRLL RFKGRPQELT PKAQILQALG
     WLYPAKFGTN PPFDRHDWFV LRQTPSGPKE VRYVIDYYSG PPEPTGEPVF YLDIRPALDS
     PTAAIERLMR WGGDVWYRAS GGAVRENNNS
//

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