(data stored in ACNUC9306 zone)

EMBL: L27090

ID   L27090; SV 1; linear; mRNA; STD; MUS; 2374 BP.
XX
AC   L27090;
XX
DT   25-MAR-1994 (Rel. 39, Created)
DT   24-SEP-2008 (Rel. 97, Last updated, Version 4)
XX
DE   Mus musculus neurofibromatosis 2 (Nf-2) gene mRNA, complete cds.
XX
KW   merlin tumor suppressor; moesin-ezrin-radixin-like protein; murine merlin;
KW   murine neurofibromatosis 2 homologue.
XX
OS   Mus musculus (house mouse)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
XX
RN   [1]
RP   1-2374
RX   DOI; 10.1093/hmg/3.3.407.
RX   PUBMED; 8012352.
RA   Haase V.H., Trofatter J.A., MacCollin M., Tarttelin E., Gusella J.F.,
RA   Ramesh V.;
RT   "The murine NF2 homologue encodes a highly conserved merlin protein with
RT   alternative forms";
RL   Hum. Mol. Genet. 3(3):407-411(1994).
XX
DR   MD5; 96d963cf20e604ef1984603833af2af6.
DR   Ensembl-Gn; ENSMUSG00000009073; mus_musculus.
DR   Ensembl-Gn; MGP_129S1SvImJ_G0017989; mus_musculus_129s1svimj.
DR   Ensembl-Gn; MGP_AJ_G0017962; mus_musculus_aj.
DR   Ensembl-Gn; MGP_AKRJ_G0017926; mus_musculus_akrj.
DR   Ensembl-Gn; MGP_BALBcJ_G0017930; mus_musculus_balbcj.
DR   Ensembl-Gn; MGP_C3HHeJ_G0017743; mus_musculus_c3hhej.
DR   Ensembl-Gn; MGP_C57BL6NJ_G0018382; mus_musculus_c57bl6nj.
DR   Ensembl-Gn; MGP_CASTEiJ_G0017306; mus_musculus_casteij.
DR   Ensembl-Gn; MGP_CBAJ_G0017718; mus_musculus_cbaj.
DR   Ensembl-Gn; MGP_DBA2J_G0017828; mus_musculus_dba2j.
DR   Ensembl-Gn; MGP_FVBNJ_G0017820; mus_musculus_fvbnj.
DR   Ensembl-Gn; MGP_LPJ_G0017899; mus_musculus_lpj.
DR   Ensembl-Gn; MGP_NODShiLtJ_G0017846; mus_musculus_nodshiltj.
DR   Ensembl-Gn; MGP_NZOHlLtJ_G0018422; mus_musculus_nzohlltj.
DR   Ensembl-Gn; MGP_PWKPhJ_G0017085; mus_musculus_pwkphj.
DR   Ensembl-Gn; MGP_WSBEiJ_G0017359; mus_musculus_wsbeij.
DR   Ensembl-Tr; ENSMUST00000053079; mus_musculus.
DR   Ensembl-Tr; ENSMUST00000056290; mus_musculus.
DR   Ensembl-Tr; ENSMUST00000109910; mus_musculus.
DR   Ensembl-Tr; MGP_129S1SvImJ_T0027828; mus_musculus_129s1svimj.
DR   Ensembl-Tr; MGP_AJ_T0027797; mus_musculus_aj.
DR   Ensembl-Tr; MGP_AKRJ_T0027758; mus_musculus_akrj.
DR   Ensembl-Tr; MGP_BALBcJ_T0027776; mus_musculus_balbcj.
DR   Ensembl-Tr; MGP_C3HHeJ_T0027574; mus_musculus_c3hhej.
DR   Ensembl-Tr; MGP_C57BL6NJ_T0028278; mus_musculus_c57bl6nj.
DR   Ensembl-Tr; MGP_CASTEiJ_T0027170; mus_musculus_casteij.
DR   Ensembl-Tr; MGP_CBAJ_T0027503; mus_musculus_cbaj.
DR   Ensembl-Tr; MGP_DBA2J_T0027632; mus_musculus_dba2j.
DR   Ensembl-Tr; MGP_FVBNJ_T0027614; mus_musculus_fvbnj.
DR   Ensembl-Tr; MGP_LPJ_T0027746; mus_musculus_lpj.
DR   Ensembl-Tr; MGP_NODShiLtJ_T0027598; mus_musculus_nodshiltj.
DR   Ensembl-Tr; MGP_NZOHlLtJ_T0028302; mus_musculus_nzohlltj.
DR   Ensembl-Tr; MGP_PWKPhJ_T0026858; mus_musculus_pwkphj.
DR   Ensembl-Tr; MGP_WSBEiJ_T0027085; mus_musculus_wsbeij.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..2374
FT                   /organism="Mus musculus"
FT                   /map="11"
FT                   /mol_type="mRNA"
FT                   /cell_line="C1300 neuroblasts"
FT                   /db_xref="taxon:10090"
FT   5'UTR           1..10
FT   CDS_pept        11..1801
FT                   /codon_start=1
FT                   /gene="Nf-2"
FT                   /standard_name="neurofibromatosis 2"
FT                   /product="merlin"
FT                   /db_xref="GOA:P46662"
FT                   /db_xref="InterPro:IPR000299"
FT                   /db_xref="InterPro:IPR000798"
FT                   /db_xref="InterPro:IPR008954"
FT                   /db_xref="InterPro:IPR011174"
FT                   /db_xref="InterPro:IPR011259"
FT                   /db_xref="InterPro:IPR011993"
FT                   /db_xref="InterPro:IPR014352"
FT                   /db_xref="InterPro:IPR018979"
FT                   /db_xref="InterPro:IPR018980"
FT                   /db_xref="InterPro:IPR019747"
FT                   /db_xref="InterPro:IPR019748"
FT                   /db_xref="InterPro:IPR019749"
FT                   /db_xref="InterPro:IPR029071"
FT                   /db_xref="InterPro:IPR035963"
FT                   /db_xref="InterPro:IPR041789"
FT                   /db_xref="MGI:MGI:97307"
FT                   /db_xref="PDB:1ISN"
FT                   /db_xref="PDB:3WA0"
FT                   /db_xref="PDB:4P7I"
FT                   /db_xref="PDB:4ZRK"
FT                   /db_xref="UniProtKB/Swiss-Prot:P46662"
FT                   /protein_id="AAA63648.1"
FT                   /translation="MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKD
FT                   LFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPEN
FT                   AEEELVQEITQHLFFLQVKKQILDEKVYCPPEASVLLASYAVQAKYGDYDPSVHKRGFL
FT                   AQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYF
FT                   TIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKID
FT                   VFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLA
FT                   REKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLA
FT                   QKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDL
FT                   QEAREAERRAKQKLLEIATKPTYPPMNPIPPPLPPDIPSFDIIADSLSFDFKDTDMKRL
FT                   SMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKEAETALDVLHSESSDRGGPSSKHN
FT                   TIKKLTLQSAKSRVAFFEEL"
FT   3'UTR           1802..2374
XX
SQ   Sequence 2374 BP; 624 A; 578 C; 652 G; 520 T; 0 other;
     accccgcgcc atggccggag ccatcgcttc tcgcatgagc ttcagctcac tcaagaggaa        60
     gcagcccaag acattcacgg tgcggatcgt caccatggac gccgagatgg agttcaactg       120
     cgagatgaaa tggaagggga aggacctgtt tgatttggtg tgccggacac tggggcttcg       180
     ggaaacctgg ttctttggac tgcagtatac aatcaaggac acggtggcct ggctcaaaat       240
     ggacaagaag gtgttggatc atgatgtttc gaaggaagaa ccagttacct ttcacttcct       300
     ggccaaattt tatcctgaaa atgctgagga ggagctagtt caagagatca cgcaacactt       360
     atttttctta caggtgaaga agcagatttt ggatgaaaag gtctactgcc ctcccgaggc       420
     gtccgtgctc ttggcgtcat atgctgtcca ggccaagtat ggcgactatg acccctctgt       480
     gcacaagcgg ggatttttag cccaagagga attgctcccg aaaagggtga taaatctcta       540
     tcagatgact ccggaaatgt gggaggagag aattacggct tggtatgcgg agcaccgggg       600
     cagagccagg gatgaagctg aaatggagta tttgaagata gctcaggacc tggagatgta       660
     tggtgtgaac tactttacaa tccggaataa aaagggcaca gagttgctgc ttggagtgga       720
     tgctcttggg cttcatatct acgaccctga gaacaggctg acccccaaga tctccttccc       780
     atggaatgaa atccgaaaca tctcctacag cgacaaggag tttactatta aaccactgga       840
     taagaaaatt gatgtcttca aatttaactc ctcaaagctt cgtgttaata agctgattct       900
     tcagctatgt attgggaacc atgacctatt tatgaggcga cggaaagctg actctttaga       960
     agttcagcag atgaaagccc aggccaggga agagaaggct agaaagcaga tggaaaggca      1020
     gcggctggct cgagagaagc agatgcggga ggaggccgag cgtacaagag atgagttaga      1080
     gaggaggctc ctgcagatga aagaagaagc aacgatggcc aatgaagctc tgatgcgctc      1140
     tgaggagaca gctgatctgt tggctgaaaa ggctcagatc acagaggagg aggccaagct      1200
     tttggcacaa aaggctgcag aggctgagca agagatgcag cgaatcaagg ccacggccat      1260
     tcggacagag gaggagaagc gcctgatgga gcagaaggtg ctggaggctg aagtgctggc      1320
     attgaagatg gctgaggagt cagagaggag ggccaaggag gctgatcagt taaagcaaga      1380
     cttgcaagaa gcccgagaag cagaacgaag agccaagcag aagctcttag aaatcgccac      1440
     caagcccacc tatccaccca tgaacccaat tccaccacca ctgcctcctg acataccgag      1500
     cttcgacatt attgctgaca gcttgtcatt cgacttcaag gatacggaca tgaagcgact      1560
     ttccatggag atagagaaag aaaaagtgga gtacatggag aagagcaagc acctgcagga      1620
     gcagctcaac gagctcaaga ctgagatcga ggccttgaaa ctcaaagagg cggagacggc      1680
     cttggacgtc ctacacagcg agagctcaga cagaggcggc cccagcagca agcataatac      1740
     cattaaaaag ctcactctgc agagcgccaa gtcccgagtg gccttctttg aagaactcta      1800
     gcaggtgacc ccggccacct cctgccacat ctgctgctcc tgacaccaac aggatgggcc      1860
     agacccaaaa ggaaccatca gtagagggct ggcttgtttg ggaactcttg agttgagggc      1920
     cccgggcact ctgaccctat agagaggttt ctcaatgtgt tctagttctc cttgcctcct      1980
     gcatacctgc atatctctct ctccctccct ctctctctct ctccctctcc ttctctctct      2040
     ctctctctct ctctctctct ctctctttct ctctctctct ctctcttata taaatacttg      2100
     ttgtgtgtgg gctgccatcc ttcctgcacc ttcgactgtg gtgcacgggt tgctgtgctt      2160
     gctgacattg agaatcggct gtgggagtcc agtgtgaaag ctggctgaaa tctaccatgc      2220
     aggtgctacc cactccccaa ctgggcttct gggatgggcc tcccctccaa gcatggggta      2280
     gaagtgtgga ctggcttagc tcagaaccag gaatgggggt tggggattta gctcagtgag      2340
     agcgcttact cgggccctgg gttcggtcct cagc                                  2374
//

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