(data stored in ACNUC1104 zone)

SWISSPROT: EFPA_MYCTO

ID   EFPA_MYCTO              Reviewed;         530 AA.
AC   P9WJY4; L0TDQ9; O05813; Q50747; Q7D6G8;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   08-MAY-2019, entry version 24.
DE   RecName: Full=Uncharacterized MFS-type transporter EfpA;
DE   AltName: Full=Efflux protein A;
GN   Name=efpA; OrderedLocusNames=MT2912;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/JB.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H.,
RA   Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D.,
RA   Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M.,
RA   Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C.,
RA   Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
DR   EMBL; AE000516; AAK47238.1; -; Genomic_DNA.
DR   PIR; A70589; A70589.
DR   RefSeq; WP_003414532.1; NZ_KK341227.1.
DR   EnsemblBacteria; AAK47238; AAK47238; MT2912.
DR   KEGG; mtc:MT2912; -.
DR   PATRIC; fig|83331.31.peg.3146; -.
DR   BioCyc; MTBCDC1551:GT3Z-7384-MONOMER; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; P9WJY4.
DR   SWISS-2DPAGE; P9WJY4.
KW   Cell membrane; Complete proteome; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN         1    530       Uncharacterized MFS-type transporter
FT                                EfpA.
FT                                /FTId=PRO_0000427749.
FT   TOPO_DOM      1     50       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     51     71       Helical. {ECO:0000255}.
FT   TOPO_DOM     72     91       Extracellular. {ECO:0000255}.
FT   TRANSMEM     92    112       Helical. {ECO:0000255}.
FT   TOPO_DOM    113    119       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    120    140       Helical. {ECO:0000255}.
FT   TOPO_DOM    141    150       Extracellular. {ECO:0000255}.
FT   TRANSMEM    151    171       Helical. {ECO:0000255}.
FT   TOPO_DOM    172    180       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    181    201       Helical. {ECO:0000255}.
FT   TOPO_DOM    202    203       Extracellular. {ECO:0000255}.
FT   TRANSMEM    204    224       Helical. {ECO:0000255}.
FT   TOPO_DOM    225    239       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    240    260       Helical. {ECO:0000255}.
FT   TOPO_DOM    261    266       Extracellular. {ECO:0000255}.
FT   TRANSMEM    267    287       Helical. {ECO:0000255}.
FT   TOPO_DOM    288    306       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    307    327       Helical. {ECO:0000255}.
FT   TOPO_DOM    328    343       Extracellular. {ECO:0000255}.
FT   TRANSMEM    344    364       Helical. {ECO:0000255}.
FT   TOPO_DOM    365    370       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    371    391       Helical. {ECO:0000255}.
FT   TOPO_DOM    392    400       Extracellular. {ECO:0000255}.
FT   TRANSMEM    401    421       Helical. {ECO:0000255}.
FT   TOPO_DOM    422    437       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    438    458       Helical. {ECO:0000255}.
FT   TOPO_DOM    459    488       Extracellular. {ECO:0000255}.
FT   TRANSMEM    489    509       Helical. {ECO:0000255}.
FT   TOPO_DOM    510    530       Cytoplasmic. {ECO:0000255}.
SQ   SEQUENCE   530 AA;  55580 MW;  189F752ECB053BED CRC64;
     MTALNDTERA VRNWTAGRPH RPAPMRPPRS EETASERPSR YYPTWLPSRS FIAAVIAIGG
     MQLLATMDST VAIVALPKIQ NELSLSDAGR SWVITAYVLT FGGLMLLGGR LGDTIGRKRT
     FIVGVALFTI SSVLCAVAWD EATLVIARLS QGVGSAIASP TGLALVATTF PKGPARNAAT
     AVFAAMTAIG SVMGLVVGGA LTEVSWRWAF LVNVPIGLVM IYLARTALRE TNKERMKLDA
     TGAILATLAC TAAVFAFSIG PEKGWMSGIT IGSGLVALAA AVAFVIVERT AENPVVPFHL
     FRDRNRLVTF SAILLAGGVM FSLTVCIGLY VQDILGYSAL RAGVGFIPFV IAMGIGLGVS
     SQLVSRFSPR VLTIGGGYLL FGAMLYGSFF MHRGVPYFPN LVMPIVVGGI GIGMAVVPLT
     LSAIAGVGFD QIGPVSAIAL MLQSLGGPLV LAVIQAVITS RTLYLGGTTG PVKFMNDVQL
     AALDHAYTYG LLWVAGAAII VGGMALFIGY TPQQVAHAQE VKEAIDAGEL
//

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