(data stored in ACNUC23059 zone)

SWISSPROT: CDKA1_MOUSE

ID   CDKA1_MOUSE             Reviewed;         114 AA.
AC   O35207; B2RV53; Q3SYK3; Q6ZWZ1;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 2.
DT   08-MAY-2019, entry version 118.
DE   RecName: Full=Cyclin-dependent kinase 2-associated protein 1;
DE            Short=CDK2-associated protein 1;
DE   AltName: Full=Deleted in oral cancer 1;
DE            Short=DOC-1;
DE   AltName: Full=Putative oral cancer suppressor;
GN   Name=Cdk2ap1; Synonyms=Cdkap1, Doc1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Liver;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N-3; TISSUE=Brain, Colon, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 6-114.
RC   TISSUE=Fibroblast;
RA   Wong D.T.W., Tsuji T., Todd R., McBride J.;
RT   "Molecular cloning and characterization of mouse doc-1 oral tumor
RT   suppressor gene.";
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   FUNCTION, AND INTERACTION WITH CDK2.
RX   PubMed=10938106; DOI=10.1128/MCB.20.17.6300-6307.2000;
RA   Shintani S., Ohyama H., Zhang X., McBride J., Matsuo K., Tsuji T.,
RA   Hu M.G., Hu G., Kohno Y., Lerman M., Todd R., Wong D.T.;
RT   "p12(DOC-1) is a novel cyclin-dependent kinase 2-associated protein.";
RL   Mol. Cell. Biol. 20:6300-6307(2000).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: specific inhibitor of the cell-cycle kinase CDK2.
CC       {ECO:0000269|PubMed:10938106}.
CC   -!- SUBUNIT: Homodimer (By similarity). Interacts with monomeric
CC       unphosphorylated CDK2 (PubMed:10938106). Interacts with CDK2AP2
CC       (By similarity). {ECO:0000250|UniProtKB:O14519,
CC       ECO:0000269|PubMed:10938106}.
CC   -!- PTM: Phosphorylated in vitro by IKBKE at Ser-45. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDK2AP family. {ECO:0000305}.
DR   EMBL; AK004852; BAB23616.1; -; mRNA.
DR   EMBL; AL645849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC083075; AAH83075.1; -; mRNA.
DR   EMBL; BC103772; AAI03773.1; -; mRNA.
DR   EMBL; BC147052; AAI47053.1; -; mRNA.
DR   EMBL; BC147053; AAI47054.1; -; mRNA.
DR   EMBL; AF011644; AAB65752.1; -; mRNA.
DR   CCDS; CCDS39279.1; -.
DR   RefSeq; NP_038840.2; NM_013812.2.
DR   SMR; O35207; -.
DR   BioGrid; 199264; 13.
DR   IntAct; O35207; 13.
DR   STRING; 10090.ENSMUSP00000100565; -.
DR   PhosphoSitePlus; O35207; -.
DR   EPD; O35207; -.
DR   MaxQB; O35207; -.
DR   PaxDb; O35207; -.
DR   PeptideAtlas; O35207; -.
DR   PRIDE; O35207; -.
DR   Ensembl; ENSMUST00000031341; ENSMUSP00000031341; ENSMUSG00000029394.
DR   Ensembl; ENSMUST00000104959; ENSMUSP00000100565; ENSMUSG00000078154.
DR   GeneID; 13445; -.
DR   KEGG; mmu:13445; -.
DR   UCSC; uc008zpo.1; mouse.
DR   CTD; 8099; -.
DR   MGI; MGI:1202069; Cdk2ap1.
DR   eggNOG; KOG4713; Eukaryota.
DR   eggNOG; ENOG41126TJ; LUCA.
DR   GeneTree; ENSGT00940000155149; -.
DR   HOGENOM; HOG000035115; -.
DR   InParanoid; O35207; -.
DR   OMA; ISDGHIC; -.
DR   OrthoDB; 1630301at2759; -.
DR   PhylomeDB; O35207; -.
DR   TreeFam; TF101037; -.
DR   ChiTaRS; Car6; mouse.
DR   PRO; PR:O35207; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Proteomes; UP000000589; Chromosome 5.
DR   Bgee; ENSMUSG00000029394; Expressed in 35 organ(s), highest expression level in skeletal muscle tissue.
DR   ExpressionAtlas; O35207; baseline and differential.
DR   Genevisible; O35207; MM.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR   GO; GO:0070182; F:DNA polymerase binding; ISO:MGI.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0060325; P:face morphogenesis; IMP:MGI.
DR   GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:MGI.
DR   InterPro; IPR017266; DOC_1/2.
DR   PANTHER; PTHR22607; PTHR22607; 1.
DR   Pfam; PF09806; CDK2AP; 1.
DR   PIRSF; PIRSF037709; CDK2-associated_p2; 1.
PE   1: Evidence at protein level;
DR   PRODOM; O35207.
DR   SWISS-2DPAGE; O35207.
KW   Cell cycle; Complete proteome; Disulfide bond; Phosphoprotein;
KW   Reference proteome; Tumor suppressor.
FT   CHAIN         1    114       Cyclin-dependent kinase 2-associated
FT                                protein 1.
FT                                /FTId=PRO_0000089454.
FT   REGION        1     60       Intrinsically disordered. {ECO:0000250}.
FT   REGION       19     24       Interaction with CDK2AP2.
FT                                {ECO:0000250|UniProtKB:O14519}.
FT   MOD_RES      45     45       Phosphoserine; by IKKE.
FT                                {ECO:0000250|UniProtKB:O14519}.
FT   DISULFID    104    104       Interchain. {ECO:0000255}.
SQ   SEQUENCE   114 AA;  12354 MW;  6421DD87E438F02D CRC64;
     MSYKPNLTAH MPAAALNAGS VHSPSTSMAT SSQYRQLLSD YGPPSLGYTQ GTGNSQVPQS
     KYAELLAIIE ELGKEIRPTY AGSKSAMERL KRGIIHARSL VRECLAETER NARS
//

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