(data stored in ACNUC1829 zone)

SWISSPROT: CD151_MOUSE

ID   CD151_MOUSE             Reviewed;         253 AA.
AC   O35566; O89118;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   07-JUN-2017, entry version 132.
DE   RecName: Full=CD151 antigen;
DE   AltName: Full=GP27;
DE   AltName: Full=Membrane glycoprotein SFA-1;
DE   AltName: Full=Platelet-endothelial tetraspan antigen 3;
DE            Short=PETA-3;
DE   AltName: CD_antigen=CD151;
GN   Name=Cd151; Synonyms=Peta3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9294006; DOI=10.1016/S0167-4781(97)00095-X;
RA   Hasegawa H., Watanabe H., Nomura T., Utsunomiya Y., Yanagisawa K.,
RA   Fujita S.;
RT   "Molecular cloning and expression of mouse homologue of SFA-1/PETA-3
RT   (CD151), a member of the transmembrane 4 superfamily.";
RL   Biochim. Biophys. Acta 1353:125-130(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=129/Sv;
RX   PubMed=9602068; DOI=10.1016/S0167-4781(98)00034-7;
RA   Fitter S., Seldin M.F., Ashman L.K.;
RT   "Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1);
RT   genomic structure, chromosomal localisation and identification of 2
RT   novel splice forms.";
RL   Biochim. Biophys. Acta 1398:75-85(1998).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
RC   Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Essential for the proper assembly of the glomerular and
CC       tubular basement membranes in kidney. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000305}.
DR   EMBL; D89290; BAA22447.1; -; mRNA.
DR   EMBL; AF033620; AAC25952.1; -; Genomic_DNA.
DR   EMBL; U89772; AAC25976.1; -; mRNA.
DR   CCDS; CCDS22017.1; -.
DR   RefSeq; NP_001104519.1; NM_001111049.1.
DR   RefSeq; NP_001104520.1; NM_001111050.1.
DR   RefSeq; NP_033972.2; NM_009842.3.
DR   UniGene; Mm.30246; -.
DR   UniGene; Mm.483720; -.
DR   ProteinModelPortal; O35566; -.
DR   BioGrid; 198574; 1.
DR   IntAct; O35566; 2.
DR   MINT; MINT-4090123; -.
DR   STRING; 10090.ENSMUSP00000061636; -.
DR   iPTMnet; O35566; -.
DR   PhosphoSitePlus; O35566; -.
DR   SwissPalm; O35566; -.
DR   MaxQB; O35566; -.
DR   PaxDb; O35566; -.
DR   PeptideAtlas; O35566; -.
DR   PRIDE; O35566; -.
DR   Ensembl; ENSMUST00000058746; ENSMUSP00000061636; ENSMUSG00000025510.
DR   Ensembl; ENSMUST00000106000; ENSMUSP00000101622; ENSMUSG00000025510.
DR   Ensembl; ENSMUST00000177840; ENSMUSP00000136331; ENSMUSG00000025510.
DR   GeneID; 12476; -.
DR   KEGG; mmu:12476; -.
DR   UCSC; uc009kll.2; mouse.
DR   CTD; 977; -.
DR   MGI; MGI:1096360; Cd151.
DR   eggNOG; KOG3882; Eukaryota.
DR   eggNOG; ENOG4111IRY; LUCA.
DR   GeneTree; ENSGT00880000137851; -.
DR   HOGENOM; HOG000230651; -.
DR   HOVERGEN; HBG107306; -.
DR   InParanoid; O35566; -.
DR   KO; K06537; -.
DR   OMA; CATFKEQ; -.
DR   OrthoDB; EOG091G0CQO; -.
DR   PhylomeDB; O35566; -.
DR   TreeFam; TF352892; -.
DR   Reactome; R-MMU-2022090; Assembly of collagen fibrils and other multimeric structures.
DR   Reactome; R-MMU-446107; Type I hemidesmosome assembly.
DR   PRO; PR:O35566; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   Bgee; ENSMUSG00000025510; -.
DR   CleanEx; MM_CD151; -.
DR   ExpressionAtlas; O35566; baseline and differential.
DR   Genevisible; O35566; MM.
DR   GO; GO:0005604; C:basement membrane; ISO:MGI.
DR   GO; GO:0005925; C:focal adhesion; ISO:MGI.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005178; F:integrin binding; ISO:MGI.
DR   GO; GO:0016477; P:cell migration; IMP:MGI.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0042098; P:T cell proliferation; IMP:MGI.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR000301; Tetraspanin.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   1: Evidence at protein level;
DR   PRODOM; O35566.
DR   SWISS-2DPAGE; O35566.
KW   Complete proteome; Glycoprotein; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN         1    253       CD151 antigen.
FT                                /FTId=PRO_0000219232.
FT   TOPO_DOM      1     18       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     19     39       Helical. {ECO:0000255}.
FT   TOPO_DOM     40     57       Extracellular. {ECO:0000255}.
FT   TRANSMEM     58     78       Helical. {ECO:0000255}.
FT   TOPO_DOM     79     91       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     92    112       Helical. {ECO:0000255}.
FT   TOPO_DOM    113    221       Extracellular. {ECO:0000255}.
FT   TRANSMEM    222    242       Helical. {ECO:0000255}.
FT   TOPO_DOM    243    253       Cytoplasmic. {ECO:0000255}.
FT   LIPID        11     11       S-palmitoyl cysteine. {ECO:0000250}.
FT   LIPID        15     15       S-palmitoyl cysteine. {ECO:0000250}.
FT   LIPID       242    242       S-palmitoyl cysteine. {ECO:0000250}.
FT   LIPID       243    243       S-palmitoyl cysteine. {ECO:0000250}.
FT   CARBOHYD    159    159       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CONFLICT    237    237       G -> S (in Ref. 1; BAA22447).
FT                                {ECO:0000305}.
SQ   SEQUENCE   253 AA;  28246 MW;  AEBEEBCE2D765F1B CRC64;
     MGEFNEKKAT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS LLASSTYLAT
     AYILVVAGVV VMVTGVLGCC ATFKERRNLL RLYFILLLII FLLEIIAGIL AYVYYQQLNT
     ELKENLKDTM VKRYHQSGHE GVSSAVDKLQ QEFHCCGSNN SQDWQDSEWI RSGEADSRVV
     PDSCCKTMVA GCGKRDHASN IYKVEGGCIT KLETFIQEHL RVIGAVGIGI ACVQVFGMIF
     TCCLYRSLKL EHY
//

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