(data stored in ACNUC8465 zone)

SWISSPROT: O49975_MAIZE

ID   O49975_MAIZE            Unreviewed;       355 AA.
AC   O49975;
DT   01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT   01-JUN-1998, sequence version 1.
DT   11-DEC-2019, entry version 137.
DE   SubName: Full=MEK homolog1 {ECO:0000313|EMBL:ONM38571.1};
DE   SubName: Full=MKK6-putative MAPKK {ECO:0000313|EMBL:ACG40591.1};
DE   SubName: Full=Protein kinase ZmMEK1 {ECO:0000313|EMBL:AAC83393.1};
GN   Name=542356 {ECO:0000313|EnsemblPlants:Zm00001d043609_P001};
GN   ORFNames=ZEAMMB73_Zm00001d043609 {ECO:0000313|EMBL:ONM38571.1};
OS   Zea mays (Maize).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX   NCBI_TaxID=4577 {ECO:0000313|EMBL:AAC83393.1};
RN   [1] {ECO:0000313|EMBL:AAC83393.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MERIT {ECO:0000313|EMBL:AAC83393.1};
RC   TISSUE=Root tip {ECO:0000313|EMBL:AAC83393.1};
RX   PubMed=9821688; DOI=10.1007/s004250050435;
RA   Hardin S.C., Wolniak S.M.;
RT   "Molecular cloning and characterization of maize ZmMEK1, a protein kinase
RT   with a catalytic domain homologous to mitogen- and stress-activated protein
RT   kinase kinases.";
RL   Planta 206:577-584(1998).
RN   [2] {ECO:0000313|EMBL:ACG40591.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18937034; DOI=10.1007/s11103-008-9415-4;
RA   Alexandrov N.N., Brover V.V., Freidin S., Troukhan M.E., Tatarinova T.V.,
RA   Zhang H., Swaller T.J., Lu Y.P., Bouck J., Flavell R.B., Feldmann K.A.;
RT   "Insights into corn genes derived from large-scale cDNA sequencing.";
RL   Plant Mol. Biol. 69:179-194(2009).
RN   [3] {ECO:0000313|EMBL:ACN35425.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=B73 {ECO:0000313|EMBL:ACN35425.1};
RX   PubMed=19936069; DOI=10.1371/journal.pgen.1000740;
RA   Soderlund C., Descour A., Kudrna D., Bomhoff M., Boyd L., Currie J.,
RA   Angelova A., Collura K., Wissotski M., Ashley E., Morrow D., Fernandes J.,
RA   Walbot V., Yu Y.;
RT   "Sequencing, mapping, and analysis of 27,455 maize full-length cDNAs.";
RL   PLoS Genet. 5:E1000740-E1000740(2009).
RN   [4] {ECO:0000313|EMBL:ONM38571.1, ECO:0000313|EnsemblPlants:Zm00001d043609_P001, ECO:0000313|Proteomes:UP000007305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001d043609_P001,
RC   ECO:0000313|Proteomes:UP000007305};
RC   TISSUE=Seedling {ECO:0000313|EMBL:ONM38571.1};
RG   Maize Genome Sequencing Project;
RA   Ware D.;
RT   "Update maize B73 reference genome by single molecule sequencing
RT   technologies.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EnsemblPlants:Zm00001d043609_P001}
RP   IDENTIFICATION.
RC   STRAIN=cv. B73 {ECO:0000313|EnsemblPlants:Zm00001d043609_P001};
RG   EnsemblPlants;
RL   Submitted (MAY-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily.
CC       {ECO:0000256|RuleBase:RU000304}.
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DR   EMBL; U83625; AAC83393.1; -; mRNA.
DR   EMBL; EU968473; ACG40591.1; -; mRNA.
DR   EMBL; BT068528; ACN35425.1; -; mRNA.
DR   EMBL; CM007649; ONM38571.1; -; Genomic_DNA.
DR   PIR; T02056; T02056.
DR   RefSeq; NP_001105403.1; NM_001111933.1.
DR   STRING; 4577.GRMZM2G167856_P01; -.
DR   EnsemblPlants; Zm00001d043609_T001; Zm00001d043609_P001; Zm00001d043609.
DR   GeneID; 542356; -.
DR   Gramene; Zm00001d043609_T001; Zm00001d043609_P001; Zm00001d043609.
DR   KEGG; zma:542356; -.
DR   eggNOG; KOG0581; Eukaryota.
DR   eggNOG; ENOG410XQ5A; LUCA.
DR   HOGENOM; HOG000234206; -.
DR   KO; K04368; -.
DR   OMA; WGTPFEQ; -.
DR   OrthoDB; 688282at2759; -.
DR   Proteomes; UP000007305; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0009524; C:phragmoplast; IEA:EnsemblPlants.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004708; F:MAP kinase kinase activity; IEA:EnsemblPlants.
DR   GO; GO:0051019; F:mitogen-activated protein kinase binding; IEA:EnsemblPlants.
DR   GO; GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IEA:EnsemblPlants.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
DR   GO; GO:0002229; P:defense response to oomycetes; IEA:EnsemblPlants.
DR   GO; GO:0010311; P:lateral root formation; IEA:EnsemblPlants.
DR   GO; GO:0007112; P:male meiosis cytokinesis; IEA:EnsemblPlants.
DR   GO; GO:0023014; P:signal transduction by protein phosphorylation; IBA:GO_Central.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; O49975.
DR   SWISS-2DPAGE; O49975.
KW   ATP-binding {ECO:0000256|RuleBase:RU000304};
KW   Kinase {ECO:0000313|EMBL:AAC83393.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000304};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007305};
KW   Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
KW   Transferase {ECO:0000313|EMBL:AAC83393.1}.
FT   DOMAIN          71..330
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
SQ   SEQUENCE   355 AA;  39875 MW;  09F15248B04EBCF3 CRC64;
     MKGKKPVKEL KLTVPAQETP VDKFLTASGT FKDGELRLNQ SGLRLISEEN GDEDESTKLK
     VEDVQLSMDD LEMIQVIGKG SGGVVQLVRH KWVGTLFALK GIQMNIQESV RKQIVQELKI
     NQATQSPHIV MCHQSFYHNG VIYLVLEYMD RGSLADIVKQ VKTILEPYLA VLCKQVLEGL
     LYLHHQRHVI HRDIKPSNLL VNRKGEVKIT DFGVSAVLAS SIGQRDTFVG TYNYMAPERI
     SGSTYDYKSD IWSLGLVILE CAIGRFPYIP SEGEGWLSFY ELLEAIVDQP PPSAPADQFS
     PEFCSFISSC IQKDPAQRMS ASELLNHPFL KKFEDKDLNL GILVENLEPP MNIPE
//

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