(data stored in ACNUC11299 zone)

SWISSPROT: O77375_PLAF7

ID   O77375_PLAF7            Unreviewed;      2457 AA.
AC   O77375;
DT   01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1998, sequence version 1.
DT   05-JUL-2017, entry version 114.
DE   RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE            EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN   ORFNames=PF3D7_0318200 {ECO:0000313|EMBL:CAB11131.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAB11131.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|EMBL:CAB11131.1, ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=10448855; DOI=10.1038/22964;
RA   Bowman S., Lawson D., Basham D., Brown D., Chillingworth T.,
RA   Churcher C.M., Craig A., Davies R.M., Devlin K., Feltwell T.,
RA   Gentles S., Gwilliam R., Hamlin N., Harris D., Holroyd S., Hornsby T.,
RA   Horrocks P., Jagels K., Jassal B., Kyes S., McLean J., Moule S.,
RA   Mungall K., Murphy L., Oliver K., Quail M.A., Rajandream M.-A.,
RA   Rutter S., Skelton J., Squares R., Squares S., Sulston J.E.,
RA   Whitehead S., Woodward J.R., Newbold C., Barrell B.G.;
RT   "The complete nucleotide sequence of chromosome 3 of Plasmodium
RT   falciparum.";
RL   Nature 400:532-538(1999).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [3] {ECO:0000313|EMBL:CAB11131.1, ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription
CC       of DNA into RNA using the four ribonucleoside triphosphates as
CC       substrates. {ECO:0000256|RuleBase:RU004279}.
CC   -!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
CC       + RNA(n+1). {ECO:0000256|RuleBase:RU004279}.
CC   -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC       {ECO:0000256|RuleBase:RU004279}.
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DR   EMBL; AL844502; CAB11131.1; -; Genomic_DNA.
DR   PIR; T18492; T18492.
DR   RefSeq; XP_001351252.1; XM_001351216.1.
DR   ProteinModelPortal; O77375; -.
DR   SMR; O77375; -.
DR   IntAct; O77375; 1.
DR   MINT; MINT-1647573; -.
DR   EnsemblProtists; CAB11131; CAB11131; PF3D7_0318200.
DR   GeneDB; PF3D7_0318200.1:pep; -.
DR   GeneID; 814496; -.
DR   KEGG; pfa:PFC0805w; -.
DR   EuPathDB; PlasmoDB:PF3D7_0318200; -.
DR   HOGENOM; HOG000222975; -.
DR   InParanoid; O77375; -.
DR   KO; K03006; -.
DR   OMA; GKVNKFE; -.
DR   PhylomeDB; O77375; -.
DR   Reactome; R-PFA-113418; Formation of the Early Elongation Complex.
DR   Reactome; R-PFA-6781823; Formation of TC-NER Pre-Incision Complex.
DR   Reactome; R-PFA-72086; mRNA Capping.
DR   Reactome; R-PFA-73776; RNA Polymerase II Promoter Escape.
DR   Reactome; R-PFA-77075; RNA Pol II CTD phosphorylation and interaction with CE.
DR   Proteomes; UP000001450; Chromosome 3.
DR   GO; GO:0005665; C:DNA-directed RNA polymerase II, core complex; ISS:GeneDB.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; ISS:GeneDB.
DR   GO; GO:0006366; P:transcription from RNA polymerase II promoter; ISS:GeneDB.
DR   InterPro; IPR000722; RNA_pol_asu.
DR   InterPro; IPR000684; RNA_pol_II_repeat_euk.
DR   InterPro; IPR006592; RNA_pol_N.
DR   InterPro; IPR007080; RNA_pol_Rpb1_1.
DR   InterPro; IPR007066; RNA_pol_Rpb1_3.
DR   InterPro; IPR007083; RNA_pol_Rpb1_4.
DR   InterPro; IPR007081; RNA_pol_Rpb1_5.
DR   InterPro; IPR007075; RNA_pol_Rpb1_6.
DR   InterPro; IPR007073; RNA_pol_Rpb1_7.
DR   Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR   Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR   Pfam; PF04983; RNA_pol_Rpb1_3; 2.
DR   Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR   Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR   Pfam; PF04992; RNA_pol_Rpb1_6; 2.
DR   Pfam; PF04990; RNA_pol_Rpb1_7; 1.
DR   Pfam; PF05001; RNA_pol_Rpb1_R; 10.
DR   SMART; SM00663; RPOLA_N; 1.
DR   PROSITE; PS00115; RNA_POL_II_REPEAT; 3.
PE   3: Inferred from homology;
DR   PRODOM; O77375.
DR   SWISS-2DPAGE; O77375.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   DNA-directed RNA polymerase {ECO:0000256|RuleBase:RU004279,
KW   ECO:0000313|EMBL:CAB11131.1};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU004279,
KW   ECO:0000313|EMBL:CAB11131.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transcription {ECO:0000256|RuleBase:RU004279};
KW   Transferase {ECO:0000256|RuleBase:RU004279,
KW   ECO:0000313|EMBL:CAB11131.1}.
FT   DOMAIN      266    568       RPOLA_N. {ECO:0000259|SMART:SM00663}.
FT   COILED     1182   1209       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2457 AA;  278676 MW;  BB0FE1135F2FF43C CRC64;
     MTVDLNIPYS ACELKRVKRL ELGVLDPEII KKISVCEIVN VDIYKDGFPR EGGLNDIRMG
     TIDYRTLCGT CNMNVKYCPG HFGHIELAKP MYHYGFMNVV LNVLRCVCYH CGRLLCNVNS
     SKVKYIEKIK VNSLRLRKLA ELCLGIRACD HSVEEEGLNI NDNSLNNFYN NDLSNLNMNQ
     QMLLNKSNYT NIFEMVSKED VDCGCVQPKY SREGPNMYIQ FLHSSEEDID ESKRKLSAEE
     ALEILKKIRK EEMSILGFNS DRCVPASLIL TCIPIPPPCA RPYVQYGNQR SEDDLTLKLL
     DIVKTNIQLK RQTDRGAKSH VLQDLCSLLQ FHITTLFDND IPGMPIATTR SKKPIKAIRT
     RLKGKEGRLR GNLMGKRVDF SARTVITGDP NLNIDYIGVP KSVAMTLTFC ETVTPLNYDN
     LKKLVERGPY EWPGAKYIIR DNGTKYDLRH VRRNSEKELE YGYKVERHMT DEDYILFNRQ
     PSLHKMSIMG HKAKILPYST FRLNLSVTSP YNADFDGDEM NLHLAQSHET RSEIKHLMIV
     QRQIVSPQGN KPVMGIVQDS LLAIRKFTRR DNFLTKEEVM SLLIWIPYWN HVIPTPAIIK
     PRALWTGKQI FSMLLQFDDM NIEDDKNDTA NNKVGRDVNT NVNKDSSKMN TSGNYYYGNS
     TNDNNDDYLE KGNAYSRSGN NHPNSPLSIG DNINVGNVQQ NDMSSPNNNN NNNNSNNNNN
     NIGGGINSFK RFNMVKINLM RDSSTSSKDD NPYCSINDGK VIIKNNELLS GIICKRTVGS
     SSGSLIHVLW HEMGPDKTKD FLSALQKVTN NWLEYVGFTV SCSDIIASNK VLGKVREILD
     KSKSEVSKLV EKAQKGELEC QPGKSLYESF ETRVNNELNC AREMAGKVAS ESLDERNNIF
     SMVASGSKGS IINISQIISC VGQQNVEGKR IPFGFNHRSL PHFIKFDYGP ESRGFVSNSY
     LSGLTPQEVF FHAMGGREGI IDTACKTSET GYIQRRLIKA MEDVMVQYDR TVRNSYGDII
     QFLYGEDGMA GEYIEDQIID LMKLDNKEIN KLYKYNFDEE PFGKDYYIGN KNDGSRNTSY
     IDYNKQNILN QEFEELYKCK NYLCKEIFPD GDIRQHLPIN MNRLIEYAKS QFPCIPFVSN
     NNSTNNNNNN NNNNISNSRK LMDKGNLSST HNHKESKKRR KRRRRKNKFD KFKNENNELM
     SEIKKEYENN DLNNMMISKG DQSPFKGMNE FHMGVADNDM GSDLGNNNNY NNDDFVDDDY
     VDDDYDDDDD DYDDDDDYDD DDLDDDENYS DNINIGGNRK YYGNTLKNNY DENSMLNPID
     VVHKVNNFLE KLVIIKQINS NDTLSVEAQN NATILLKAHL RTYLNSKLLT QTHKVSVKGL
     DWLLQEIEKI FYKSLCHPGE CVGALAAQSI GEPATQMTLN TFHFAGVGSK NVTLGVPRLK
     ELINIVKNVK TPSTTIYLDD MVSNDQQKAK DILTKLEYTT LKQLTSHAQI IYDPNTTTTI
     LEEDKSWVNE FYEFPDEDDT QYSLGEWVLR IQLTNIHVNE KKLTMKEIVY IIYSVFSSDE
     LDIIYTDDNS EDLVLRIRVK YLNGEYNFMN YDVVDNANEQ VDEQEEDEEH LVANDRGNYD
     ETKNSTHPHH DYNNNTTNIF KSKVKNNISS DINTKNEDSI SINSSNNEQV KNINSSPVSN
     NMHNNNNNNN NDSSNINDIK VKNIKKEDGN EGALRGGGDS NTSALFGNKN SQKEDNIVNN
     NNDNNDDDEE EEEEEEDFLF GDHNVSPKNT KDGKNKNTNN KSNNNENKNK KSGNNNSNNS
     NTYDDGDVDN DNDDDNDDNK SDITIKEDND VAFMKTSTKN AEEDLELKNK NHIEHNISRE
     DTEDTFLKKL MEQCLSTLKL RGIENITKVY MREESKITYD SDNGKFVRSS HWVLDTDGCN
     LENIFCAPQV DFKKTVSNDI VEIFEVLGIE AVRRALLKEL RTVISFDSSY VNYRHLSILC
     DVMTQKGYLM SITRHGINRV DKGPLIKCSF EETVEILLEA AAFAQVDNLR GITENIMLGQ
     LCKIGTGSFD IIIDNQKLND ANQNLETIQD LTSAGFTTPD SLHVITPDGL QSPVAINTIN
     SPLPFSPTYN ANLLSPTAPI DNVNNLLSPQ YNLQNYGDNV MSPTSKDINN LDTLKLGGKF
     SPTQSPKSPT SVMHSPFSPF DHQNQQPVDA TNLLFSPKNN NIMNYNVFSP KPNINNNVIQ
     SPNIYSPNPM LDIFSPKPQI NHNIYSPSYS PTSPTYNANN AYYSPTSPKN QNDQMNVNSQ
     YNVMSPVYSV TSPKYSPTSP KYSPTSPKYS PTSPKYSPTS PKYSPTSPKY SPTSPKYSPT
     SPKYSPTSPK YSPTSPVAQN IASPNYSPYS ITSPKFSPTS PAYSISSPVY DKSGVVNAHQ
     PMSPAYILQS PVQIKQNVQD ANMFSPIQQA HVDEAKNDDP FSPMPYNIDE DEMKENM
//

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