(data stored in ACNUC31108 zone)

SWISSPROT: CD37_HUMAN

ID   CD37_HUMAN              Reviewed;         281 AA.
AC   P11049; B4DVC1; Q3KPF9;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 2.
DT   08-MAY-2019, entry version 160.
DE   RecName: Full=Leukocyte antigen CD37;
DE   AltName: Full=Tetraspanin-26;
DE            Short=Tspan-26;
DE   AltName: CD_antigen=CD37;
GN   Name=CD37; Synonyms=TSPAN26;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=2466944; DOI=10.1084/jem.169.4.1497;
RA   Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I.;
RT   "The primary structure of the human leukocyte antigen CD37, a species
RT   homologue of the rat MRC OX-44 antigen.";
RL   J. Exp. Med. 169:1497-1502(1989).
RN   [2]
RP   ERRATUM, AND SEQUENCE REVISION.
RX   PubMed=2388030; DOI=10.1084/jem.172.3.1007;
RA   Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I.;
RL   J. Exp. Med. 172:1007-1007(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
RA   Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
RA   Korn B., Zuo D., Hu Y., LaBaer J.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   INTERACTION WITH SCIMP.
RX   PubMed=21930792; DOI=10.1128/MCB.05817-11;
RA   Draber P., Vonkova I., Stepanek O., Hrdinka M., Kucova M.,
RA   Skopcova T., Otahal P., Angelisova P., Horejsi V., Yeung M., Weiss A.,
RA   Brdicka T.;
RT   "SCIMP, a transmembrane adapter protein involved in major
RT   histocompatibility complex class II signaling.";
RL   Mol. Cell. Biol. 31:4550-4562(2011).
CC   -!- SUBUNIT: Interacts with SCIMP. {ECO:0000269|PubMed:21930792}.
CC   -!- INTERACTION:
CC       P07948:LYN; NbExp=5; IntAct=EBI-6139068, EBI-79452;
CC       P29350:PTPN6; NbExp=4; IntAct=EBI-6139068, EBI-78260;
CC       P43405:SYK; NbExp=3; IntAct=EBI-6139068, EBI-78302;
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=P11049-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P11049-2; Sequence=VSP_047228;
CC         Note=Gene prediction based on EST data.;
CC       Name=3;
CC         IsoId=P11049-3; Sequence=VSP_047228, VSP_047229;
CC         Note=No experimental confirmation available.;
CC   -!- TISSUE SPECIFICITY: B-lymphocytes.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000305}.
DR   EMBL; X14046; CAA32204.1; -; mRNA.
DR   EMBL; AK301016; BAG62633.1; -; mRNA.
DR   EMBL; CR541877; CAG46675.1; -; mRNA.
DR   EMBL; BT019851; AAV38654.1; -; mRNA.
DR   EMBL; AC010524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC011450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC106752; AAI06753.1; -; mRNA.
DR   EMBL; BC110379; AAI10380.1; -; mRNA.
DR   CCDS; CCDS12760.1; -. [P11049-1]
DR   CCDS; CCDS46139.1; -. [P11049-2]
DR   PIR; A47629; A47629.
DR   RefSeq; NP_001035120.1; NM_001040031.1. [P11049-2]
DR   RefSeq; NP_001765.1; NM_001774.2. [P11049-1]
DR   RefSeq; XP_011525846.1; XM_011527544.2. [P11049-2]
DR   RefSeq; XP_016883002.1; XM_017027513.1. [P11049-2]
DR   IntAct; P11049; 10.
DR   MINT; P11049; -.
DR   STRING; 9606.ENSP00000325708; -.
DR   ChEMBL; CHEMBL3712880; -.
DR   GuidetoPHARMACOLOGY; 3010; -.
DR   iPTMnet; P11049; -.
DR   PhosphoSitePlus; P11049; -.
DR   SwissPalm; P11049; -.
DR   BioMuta; CD37; -.
DR   DMDM; 115983; -.
DR   jPOST; P11049; -.
DR   MaxQB; P11049; -.
DR   PaxDb; P11049; -.
DR   PeptideAtlas; P11049; -.
DR   PRIDE; P11049; -.
DR   ProteomicsDB; 52690; -.
DR   DNASU; 951; -.
DR   Ensembl; ENST00000323906; ENSP00000325708; ENSG00000104894. [P11049-1]
DR   Ensembl; ENST00000426897; ENSP00000413151; ENSG00000104894. [P11049-2]
DR   Ensembl; ENST00000598095; ENSP00000470394; ENSG00000104894. [P11049-3]
DR   GeneID; 951; -.
DR   KEGG; hsa:951; -.
DR   UCSC; uc002pnd.4; human. [P11049-1]
DR   CTD; 951; -.
DR   DisGeNET; 951; -.
DR   GeneCards; CD37; -.
DR   HGNC; HGNC:1666; CD37.
DR   HPA; CAB002492; -.
DR   HPA; HPA032120; -.
DR   HPA; HPA032121; -.
DR   MIM; 151523; gene.
DR   neXtProt; NX_P11049; -.
DR   OpenTargets; ENSG00000104894; -.
DR   PharmGKB; PA26213; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   eggNOG; ENOG4111IRY; LUCA.
DR   GeneTree; ENSGT00940000161485; -.
DR   HOGENOM; HOG000230651; -.
DR   InParanoid; P11049; -.
DR   KO; K06475; -.
DR   OMA; FMPLQIW; -.
DR   OrthoDB; 1207549at2759; -.
DR   PhylomeDB; P11049; -.
DR   TreeFam; TF352892; -.
DR   ChiTaRS; CD37; human.
DR   GeneWiki; CD37; -.
DR   GenomeRNAi; 951; -.
DR   PRO; PR:P11049; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000104894; Expressed in 137 organ(s), highest expression level in leukocyte.
DR   ExpressionAtlas; P11049; baseline and differential.
DR   Genevisible; P11049; HS.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0001772; C:immunological synapse; IDA:UniProtKB.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR000301; Tetraspanin.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P11049.
DR   SWISS-2DPAGE; P11049.
KW   Alternative splicing; Complete proteome; Glycoprotein; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN         1    281       Leukocyte antigen CD37.
FT                                /FTId=PRO_0000219209.
FT   TOPO_DOM      1     17       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     18     38       Helical. {ECO:0000255}.
FT   TOPO_DOM     39     59       Extracellular. {ECO:0000255}.
FT   TRANSMEM     60     74       Helical. {ECO:0000255}.
FT   TOPO_DOM     75     85       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     86    111       Helical. {ECO:0000255}.
FT   TOPO_DOM    112    241       Extracellular. {ECO:0000255}.
FT   TRANSMEM    242    266       Helical. {ECO:0000255}.
FT   TOPO_DOM    267    281       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD    170    170       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    183    183       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    188    188       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VAR_SEQ       1     68       Missing (in isoform 2 and isoform 3).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_047228.
FT   VAR_SEQ     257    281       LGFMTLSIFLCRNLDHVYNRLARYR -> VIWPRPHPRSAL
FT                                NP (in isoform 3).
FT                                {ECO:0000303|PubMed:14702039}.
FT                                /FTId=VSP_047229.
SQ   SEQUENCE   281 AA;  31703 MW;  4342C5FB4479FDC8 CRC64;
     MSAQESCLSL IKYFLFVFNL FFFVLGSLIF CFGIWILIDK TSFVSFVGLA FVPLQIWSKV
     LAISGIFTMG IALLGCVGAL KELRCLLGLY FGMLLLLFAT QITLGILIST QRAQLERSLR
     DVVEKTIQKY GTNPEETAAE ESWDYVQFQL RCCGWHYPQD WFQVLILRGN GSEAHRVPCS
     CYNLSATNDS TILDKVILPQ LSRLGHLARS RHSADICAVP AESHIYREGC AQGLQKWLHN
     NLISIVGICL GVGLLELGFM TLSIFLCRNL DHVYNRLARY R
//

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