(data stored in ACNUC1829 zone)

SWISSPROT: TSN8_HUMAN

ID   TSN8_HUMAN              Reviewed;         237 AA.
AC   P19075; B2R7T7; Q9BS78;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   07-JUN-2017, entry version 149.
DE   RecName: Full=Tetraspanin-8;
DE            Short=Tspan-8;
DE   AltName: Full=Transmembrane 4 superfamily member 3;
DE   AltName: Full=Tumor-associated antigen CO-029;
GN   Name=TSPAN8; Synonyms=TM4SF3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Colon carcinoma;
RX   PubMed=2395876; DOI=10.1073/pnas.87.17.6833;
RA   Szala S., Kasai Y., Steplewski Z., Rodeck U., Koprowski H.,
RA   Linnenbach A.J.;
RT   "Molecular cloning of cDNA for the human tumor-associated antigen CO-
RT   029 and identification of related transmembrane antigens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:6833-6837(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ILE-35 AND
RP   ALA-73.
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118.
RC   TISSUE=Liver;
RX   PubMed=19159218; DOI=10.1021/pr8008012;
RA   Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT   "Glycoproteomics analysis of human liver tissue by combination of
RT   multiple enzyme digestion and hydrazide chemistry.";
RL   J. Proteome Res. 8:651-661(2009).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Gastric, colon, rectal, and pancreatic
CC       carcinomas.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/TSPAN8ID42585ch12q21.html";
DR   EMBL; M35252; AAA35709.1; -; mRNA.
DR   EMBL; AK313112; BAG35934.1; -; mRNA.
DR   EMBL; CH471054; EAW97257.1; -; Genomic_DNA.
DR   EMBL; BC005246; AAH05246.1; -; mRNA.
DR   CCDS; CCDS8999.1; -.
DR   PIR; A36056; A36056.
DR   RefSeq; NP_004607.1; NM_004616.2.
DR   RefSeq; XP_006719646.1; XM_006719583.3.
DR   RefSeq; XP_016875402.1; XM_017019913.1.
DR   UniGene; Hs.170563; -.
DR   ProteinModelPortal; P19075; -.
DR   STRING; 9606.ENSP00000247829; -.
DR   iPTMnet; P19075; -.
DR   PhosphoSitePlus; P19075; -.
DR   BioMuta; TSPAN8; -.
DR   DMDM; 116589; -.
DR   MaxQB; P19075; -.
DR   PaxDb; P19075; -.
DR   PeptideAtlas; P19075; -.
DR   PRIDE; P19075; -.
DR   DNASU; 7103; -.
DR   Ensembl; ENST00000247829; ENSP00000247829; ENSG00000127324.
DR   Ensembl; ENST00000393330; ENSP00000377003; ENSG00000127324.
DR   Ensembl; ENST00000546561; ENSP00000447160; ENSG00000127324.
DR   GeneID; 7103; -.
DR   KEGG; hsa:7103; -.
DR   UCSC; uc001swj.2; human.
DR   CTD; 7103; -.
DR   DisGeNET; 7103; -.
DR   GeneCards; TSPAN8; -.
DR   HGNC; HGNC:11855; TSPAN8.
DR   HPA; CAB026009; -.
DR   HPA; HPA044337; -.
DR   MIM; 600769; gene.
DR   neXtProt; NX_P19075; -.
DR   OpenTargets; ENSG00000127324; -.
DR   PharmGKB; PA36556; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   eggNOG; ENOG4111IRY; LUCA.
DR   GeneTree; ENSGT00880000137858; -.
DR   HOGENOM; HOG000230651; -.
DR   HOVERGEN; HBG002324; -.
DR   InParanoid; P19075; -.
DR   KO; K17349; -.
DR   OMA; IWIRVSK; -.
DR   OrthoDB; EOG091G0K9H; -.
DR   PhylomeDB; P19075; -.
DR   TreeFam; TF352895; -.
DR   ChiTaRS; TSPAN8; human.
DR   GeneWiki; TSPAN8; -.
DR   GenomeRNAi; 7103; -.
DR   PRO; PR:P19075; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   Bgee; ENSG00000127324; -.
DR   CleanEx; HS_TSPAN8; -.
DR   Genevisible; P19075; HS.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0030195; P:negative regulation of blood coagulation; IEA:Ensembl.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR000301; Tetraspanin.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P19075.
DR   SWISS-2DPAGE; P19075.
KW   Complete proteome; Glycoprotein; Membrane; Polymorphism;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN         1    237       Tetraspanin-8.
FT                                /FTId=PRO_0000219252.
FT   TOPO_DOM      1      9       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     10     33       Helical. {ECO:0000255}.
FT   TOPO_DOM     34     57       Extracellular. {ECO:0000255}.
FT   TRANSMEM     58     72       Helical. {ECO:0000255}.
FT   TOPO_DOM     73     83       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     84    109       Helical. {ECO:0000255}.
FT   TOPO_DOM    110    205       Extracellular. {ECO:0000255}.
FT   TRANSMEM    206    230       Helical. {ECO:0000255}.
FT   TOPO_DOM    231    237       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD    118    118       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:19159218}.
FT   VARIANT      35     35       V -> I (in dbSNP:rs17849952).
FT                                {ECO:0000269|PubMed:15489334}.
FT                                /FTId=VAR_061848.
FT   VARIANT      73     73       G -> A (in dbSNP:rs3763978).
FT                                {ECO:0000269|PubMed:15489334}.
FT                                /FTId=VAR_020093.
FT   VARIANT     213    213       S -> A (in dbSNP:rs1051334).
FT                                /FTId=VAR_012054.
SQ   SEQUENCE   237 AA;  26044 MW;  D1058F054EE8C14E CRC64;
     MAGVSACIKY SMFTFNFLFW LCGILILALA IWVRVSNDSQ AIFGSEDVGS SSYVAVDILI
     AVGAIIMILG FLGCCGAIKE SRCMLLLFFI GLLLILLLQV ATGILGAVFK SKSDRIVNET
     LYENTKLLSA TGESEKQFQE AIIVFQEEFK CCGLVNGAAD WGNNFQHYPE LCACLDKQRP
     CQSYNGKQVY KETCISFIKD FLAKNLIIVI GISFGLAVIE ILGLVFSMVL YCQIGNK
//

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