(data stored in ACNUC1829 zone)

SWISSPROT: IM23_SCHMA

ID   IM23_SCHMA              Reviewed;         218 AA.
AC   P19331; Q26585;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   05-JUL-2017, entry version 80.
DE   RecName: Full=23 kDa integral membrane protein;
DE   AltName: Full=Sm23;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; Strigeidida;
OC   Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2324498;
RA   Wright M.D., Henkle K.J., Mitchell G.F.;
RT   "An immunogenic Mr 23,000 integral membrane protein of Schistosoma
RT   mansoni worms that closely resembles a human tumor-associated
RT   antigen.";
RL   J. Immunol. 144:3195-3200(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NMRI;
RX   PubMed=7821405; DOI=10.1006/expr.1995.1018;
RA   Lee K.W., Shalaby K.A., Medhat A.M., Shi H., Yang Q., Karim A.M.,
RA   Loverde P.T.;
RT   "Schistosoma mansoni: characterization of the gene encoding Sm23, an
RT   integral membrane protein.";
RL   Exp. Parasitol. 80:155-158(1995).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000305}.
DR   EMBL; M34453; AAA29900.1; -; mRNA.
DR   EMBL; L34755; AAA73525.1; -; Genomic_DNA.
DR   PIR; A43522; A43522.
DR   GeneDB; Smp_075720.1:pep; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   eggNOG; ENOG4111IRY; LUCA.
DR   HOGENOM; HOG000230651; -.
DR   OrthoDB; EOG091G12WV; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR000301; Tetraspanin.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; P19331.
DR   SWISS-2DPAGE; P19331.
KW   Glycoprotein; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN         1    218       23 kDa integral membrane protein.
FT                                /FTId=PRO_0000219282.
FT   TOPO_DOM      1     12       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     13     36       Helical. {ECO:0000255}.
FT   TOPO_DOM     37     55       Extracellular. {ECO:0000255}.
FT   TRANSMEM     56     71       Helical. {ECO:0000255}.
FT   TOPO_DOM     72     82       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     83    108       Helical. {ECO:0000255}.
FT   TOPO_DOM    109    183       Extracellular. {ECO:0000255}.
FT   TRANSMEM    184    205       Helical. {ECO:0000255}.
FT   TOPO_DOM    206    218       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD    165    165       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CONFLICT    151    151       D -> N (in Ref. 2; AAA73525).
FT                                {ECO:0000305}.
SQ   SEQUENCE   218 AA;  23684 MW;  1B31BBD34C218890 CRC64;
     MATLGTGMRC LKSCVFVLNI ICLLCSLVLI GAGAYVEVKF SQYGDNLHKV WQAAPIAIIV
     VGVIILIVSF LGCCGAIKEN VCMLYMYAFF LVVLLIAELA AAIVAVVYKD RIDSEIDALM
     TGALDKPTKE ITEFMNLIQS SFHCCGAKGP DDYRGNVPAS CKEENLTYTE GCVSVFGAFL
     KRNLVIVACV AFGVCFFQLL SIVIACCLGR QIKEYENV
//

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