(data stored in SCRATCH zone)

SWISSPROT: YNFM_ECOLI

ID   YNFM_ECOLI              Reviewed;         417 AA.
AC   P43531; P76886; P77705;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   11-DEC-2019, entry version 134.
DE   RecName: Full=Inner membrane transport protein YnfM;
GN   Name=ynfM; Synonyms=yzyC; OrderedLocusNames=b1596, JW1588;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA   Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA   Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA   Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA   Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA   Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA   Wada C., Yamamoto Y., Horiuchi T.;
RT   "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 28.0-40.1 min region on the linkage map.";
RL   DNA Res. 3:363-377(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 350-417.
RC   STRAIN=K12 / N2212;
RA   Jakubcionyte E., Apirion D., Normark S.;
RL   Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   IDENTIFICATION.
RA   Rudd K.E.;
RL   Unpublished observations (JUL-1995).
RN   [6]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
DR   EMBL; U00096; AAC74668.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA15330.1; -; Genomic_DNA.
DR   EMBL; AF405541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; F64915; F64915.
DR   RefSeq; NP_416113.1; NC_000913.3.
DR   RefSeq; WP_000091840.1; NZ_SSZK01000001.1.
DR   BioGrid; 4259121; 157.
DR   STRING; 511145.b1596; -.
DR   TCDB; 2.A.1.36.1; the major facilitator superfamily (mfs).
DR   PaxDb; P43531; -.
DR   PRIDE; P43531; -.
DR   EnsemblBacteria; AAC74668; AAC74668; b1596.
DR   EnsemblBacteria; BAA15330; BAA15330; BAA15330.
DR   GeneID; 946138; -.
DR   KEGG; ecj:JW1588; -.
DR   KEGG; eco:b1596; -.
DR   PATRIC; fig|1411691.4.peg.666; -.
DR   EchoBASE; EB2785; -.
DR   eggNOG; ENOG4105D94; Bacteria.
DR   eggNOG; ENOG410XP8J; LUCA.
DR   HOGENOM; HOG000217197; -.
DR   InParanoid; P43531; -.
DR   KO; K08224; -.
DR   PhylomeDB; P43531; -.
DR   BioCyc; EcoCyc:B1596-MONOMER; -.
DR   BioCyc; ECOL316407:JW1588-MONOMER; -.
DR   PRO; PR:P43531; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P43531.
DR   SWISS-2DPAGE; P43531.
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..417
FT                   /note="Inner membrane transport protein YnfM"
FT                   /id="PRO_0000173411"
FT   TOPO_DOM        1..38
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        60..73
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        95..101
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..125
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        147..152
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        174..190
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        212..241
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        263..264
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        286..315
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        337..364
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        386..387
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        388..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        409..417
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   417 AA;  45258 MW;  78862FD89AD1987B CRC64;
     MSRTTTVDGA PASDTDKQSI SQPNQFIKRG TPQFMRVTLA LFSAGLATFA LLYCVQPILP
     VLSQEFGLTP ANSSISLSIS TAMLAIGLLF TGPLSDAIGR KPVMVTALLL ASICTLLSTM
     MTSWHGILIM RALIGLSLSG VAAVGMTYLS EEIHPSFVAF SMGLYISGNS IGGMSGRLIS
     GVFTDFFNWR IALAAIGCFA LASALMFWKI LPESRHFRPT SLRPKTLFIN FRLHWRDRGL
     PLLFAEGFLL MGSFVTLFNY IGYRLMLSPW HVSQAVVGLL SLAYLTGTWS SPKAGTMTTR
     YGRGPVMLFS TGVMLFGLLM TLFSSLWLIF AGMLLFSAGF FAAHSVASSW IGPRAKRAKG
     QASSLYLFSY YLGSSIAGTL GGVFWHNYGW NGVGAFIALM LVIALLVGTR LHRRLHA
//

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