(data stored in ACNUC1829 zone)

SWISSPROT: CD151_HUMAN

ID   CD151_HUMAN             Reviewed;         253 AA.
AC   P48509; A8KAK8; E9PI15; Q14826; Q86U54; Q96TE3;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 3.
DT   30-AUG-2017, entry version 162.
DE   RecName: Full=CD151 antigen;
DE   AltName: Full=GP27;
DE   AltName: Full=Membrane glycoprotein SFA-1;
DE   AltName: Full=Platelet-endothelial tetraspan antigen 3;
DE            Short=PETA-3;
DE   AltName: Full=Tetraspanin-24;
DE            Short=Tspan-24;
DE   AltName: CD_antigen=CD151;
GN   Name=CD151; Synonyms=TSPAN24;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Platelet;
RX   PubMed=7632941;
RA   Fitter S., Tetaz T.J., Berndt M.C., Ashman L.K.;
RT   "Molecular cloning of cDNA encoding a novel platelet-endothelial cell
RT   tetra-span antigen, PETA-3.";
RL   Blood 86:1348-1355(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS ARG-132 AND SER-137.
RX   PubMed=8627808;
RA   Hasegawa H., Utsunomiya Y., Kishimoto K., Yanagisawa K., Fujita S.;
RT   "SFA-1, a novel cellular gene induced by human T-cell leukemia virus
RT   type 1, is a member of the transmembrane 4 superfamily.";
RL   J. Virol. 70:3258-3263(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-132 AND SER-137.
RX   PubMed=11181065; DOI=10.1006/bbrc.2001.4384;
RA   Whittock N.V., McLean W.H.I.;
RT   "Genomic organization, amplification, fine mapping, and intragenic
RT   polymorphisms of the human hemidesmosomal tetraspanin CD151 gene.";
RL   Biochem. Biophys. Res. Commun. 281:425-430(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
RA   Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
RA   Korn B., Zuo D., Hu Y., LaBaer J.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Uterus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT MET-120.
RG   SeattleSNPs variation discovery resource;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA   Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA   FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA   Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA   Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA   Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [10]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [11]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon, and Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [12]
RP   PALMITOYLATION AT CYS-11; CYS-15; CYS-242 AND CYS-243.
RX   PubMed=11907260; DOI=10.1091/mbc.01-05-0275;
RA   Yang X., Claas C., Kraeft S.K., Chen L.B., Wang Z., Kreidberg J.A.,
RA   Hemler M.E.;
RT   "Palmitoylation of tetraspanin proteins: modulation of CD151 lateral
RT   interactions, subcellular distribution, and integrin-dependent cell
RT   morphology.";
RL   Mol. Biol. Cell 13:767-781(2002).
RN   [13]
RP   FUNCTION, TISSUE SPECIFICITY, INVOLVEMENT IN RAPH BLOOD GROUP SYSTEM,
RP   INVOLVEMENT IN NPEBD, AND VARIANT HIS-178.
RX   PubMed=15265795; DOI=10.1182/blood-2004-04-1512;
RA   Karamatic Crew V., Burton N., Kagan A., Green C.A., Levene C.,
RA   Flinter F., Brady R.L., Daniels G., Anstee D.J.;
RT   "CD151, the first member of the tetraspanin (TM4) superfamily detected
RT   on erythrocytes, is essential for the correct assembly of human
RT   basement membranes in kidney and skin.";
RL   Blood 104:2217-2223(2004).
RN   [14]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [15]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [16]
RP   FUNCTION (MICROBIAL INFECTION).
RX   PubMed=24553111; DOI=10.3390/v6020893;
RA   Scheffer K.D., Berditchevski F., Florin L.;
RT   "The tetraspanin CD151 in papillomavirus infection.";
RL   Viruses 6:893-908(2014).
CC   -!- FUNCTION: Essential for the proper assembly of the glomerular and
CC       tubular basement membranes in kidney.
CC       {ECO:0000269|PubMed:15265795}.
CC   -!- FUNCTION: (Microbial infection) Plays a role in human
CC       papillomavirus 16/HPV-16 endocytosis upon binding to cell surface
CC       receptor. {ECO:0000269|PubMed:24553111}.
CC   -!- SUBUNIT: Interacts with integrins alpha3beta1, alpha5beta1,
CC       alpha3beta1 and alpha6beta4, with CD9 and CD181.
CC   -!- INTERACTION:
CC       Q8IYS0:GRAMD1C; NbExp=8; IntAct=EBI-10210332, EBI-7054335;
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in a variety of tissues including
CC       vascular endothelium and epidermis. Expressed on erythroid cells,
CC       with a higher level of expression in erythroid precursors than on
CC       mature erythrocytes. {ECO:0000269|PubMed:15265795}.
CC   -!- INDUCTION: By HTLV-1.
CC   -!- POLYMORPHISM: CD151 defines the MER2=RAPH1 antigen of the RAPH
CC       blood group system. 92% of Caucasians are MER2-positive and 8% are
CC       apparently MER2-negative. {ECO:0000269|PubMed:15265795}.
CC   -!- DISEASE: Nephropathy with pretibial epidermolysis bullosa and
CC       deafness (NPEBD) [MIM:609057]: A disorder characterized by the
CC       association of hereditary nephritis, epidermolysis bullosa,
CC       deafness, and beta-thalassemia minor.
CC       {ECO:0000269|PubMed:15265795}. Note=The disease is caused by
CC       mutations affecting the gene represented in this entry.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=dbRBC/BGMUT; Note=Blood group antigen gene
CC       mutation database;
CC       URL="https://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=raph";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/cd151/";
CC   -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC       and Haematology;
CC       URL="http://atlasgeneticsoncology.org/Genes/CD151ID967ch11p15.html";
DR   EMBL; U14650; AAA87064.1; -; mRNA.
DR   EMBL; D29963; BAA06229.1; -; mRNA.
DR   EMBL; AF315942; AAK14179.1; -; Genomic_DNA.
DR   EMBL; BT007397; AAP36061.1; -; mRNA.
DR   EMBL; BT020132; AAV38934.1; -; mRNA.
DR   EMBL; CR456826; CAG33107.1; -; mRNA.
DR   EMBL; CR542098; CAG46895.1; -; mRNA.
DR   EMBL; AK293073; BAF85762.1; -; mRNA.
DR   EMBL; DQ074789; AAY68211.1; -; Genomic_DNA.
DR   EMBL; AP006621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP006623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471158; EAX02400.1; -; Genomic_DNA.
DR   EMBL; BC001374; AAH01374.1; -; mRNA.
DR   EMBL; BC013302; AAH13302.1; -; mRNA.
DR   CCDS; CCDS7719.1; -.
DR   RefSeq; NP_001034579.1; NM_001039490.1.
DR   RefSeq; NP_004348.2; NM_004357.4.
DR   RefSeq; NP_620598.1; NM_139029.1.
DR   RefSeq; NP_620599.1; NM_139030.3.
DR   UniGene; Hs.654379; -.
DR   ProteinModelPortal; P48509; -.
DR   BioGrid; 107415; 11.
DR   IntAct; P48509; 5.
DR   STRING; 9606.ENSP00000324101; -.
DR   TCDB; 8.A.40.1.15; the tetraspanin (tetraspanin) family.
DR   iPTMnet; P48509; -.
DR   PhosphoSitePlus; P48509; -.
DR   SwissPalm; P48509; -.
DR   BioMuta; CD151; -.
DR   DMDM; 85687560; -.
DR   EPD; P48509; -.
DR   MaxQB; P48509; -.
DR   PaxDb; P48509; -.
DR   PeptideAtlas; P48509; -.
DR   PRIDE; P48509; -.
DR   DNASU; 977; -.
DR   Ensembl; ENST00000322008; ENSP00000324101; ENSG00000177697.
DR   Ensembl; ENST00000397420; ENSP00000380565; ENSG00000177697.
DR   Ensembl; ENST00000397421; ENSP00000380566; ENSG00000177697.
DR   Ensembl; ENST00000530726; ENSP00000432385; ENSG00000177697.
DR   GeneID; 977; -.
DR   KEGG; hsa:977; -.
DR   UCSC; uc001lry.4; human.
DR   CTD; 977; -.
DR   DisGeNET; 977; -.
DR   GeneCards; CD151; -.
DR   HGNC; HGNC:1630; CD151.
DR   HPA; CAB002428; -.
DR   HPA; HPA011906; -.
DR   MalaCards; CD151; -.
DR   MIM; 179620; phenotype.
DR   MIM; 602243; gene.
DR   MIM; 609057; phenotype.
DR   neXtProt; NX_P48509; -.
DR   OpenTargets; ENSG00000177697; -.
DR   Orphanet; 300333; Nephrotic syndrome-deafness-pretibial epidermolysis bullosa syndrome.
DR   PharmGKB; PA26189; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   eggNOG; ENOG4111IRY; LUCA.
DR   GeneTree; ENSGT00880000137851; -.
DR   HOGENOM; HOG000230651; -.
DR   HOVERGEN; HBG107306; -.
DR   InParanoid; P48509; -.
DR   KO; K06537; -.
DR   OMA; CATFKEQ; -.
DR   OrthoDB; EOG091G0CQO; -.
DR   PhylomeDB; P48509; -.
DR   TreeFam; TF352892; -.
DR   Reactome; R-HSA-2022090; Assembly of collagen fibrils and other multimeric structures.
DR   Reactome; R-HSA-446107; Type I hemidesmosome assembly.
DR   GeneWiki; CD151; -.
DR   GenomeRNAi; 977; -.
DR   PRO; PR:P48509; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000177697; -.
DR   CleanEx; HS_CD151; -.
DR   ExpressionAtlas; P48509; baseline and differential.
DR   Genevisible; P48509; HS.
DR   GO; GO:0005604; C:basement membrane; IDA:CACAO.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005925; C:focal adhesion; IDA:UniProtKB.
DR   GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR   GO; GO:0016020; C:membrane; TAS:ProtInc.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0005178; F:integrin binding; IPI:UniProtKB.
DR   GO; GO:0007155; P:cell adhesion; NAS:ProtInc.
DR   GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0031581; P:hemidesmosome assembly; TAS:Reactome.
DR   GO; GO:0042098; P:T cell proliferation; IEA:Ensembl.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR000301; Tetraspanin.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P48509.
DR   SWISS-2DPAGE; P48509.
KW   Blood group antigen; Complete proteome; Deafness;
KW   Epidermolysis bullosa; Glycoprotein; Lipoprotein; Membrane; Palmitate;
KW   Polymorphism; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN         1    253       CD151 antigen.
FT                                /FTId=PRO_0000219230.
FT   TOPO_DOM      1     18       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     19     39       Helical. {ECO:0000255}.
FT   TOPO_DOM     40     57       Extracellular. {ECO:0000255}.
FT   TRANSMEM     58     78       Helical. {ECO:0000255}.
FT   TOPO_DOM     79     91       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     92    112       Helical. {ECO:0000255}.
FT   TOPO_DOM    113    221       Extracellular. {ECO:0000255}.
FT   TRANSMEM    222    242       Helical. {ECO:0000255}.
FT   TOPO_DOM    243    253       Cytoplasmic. {ECO:0000255}.
FT   LIPID        11     11       S-palmitoyl cysteine.
FT                                {ECO:0000269|PubMed:11907260}.
FT   LIPID        15     15       S-palmitoyl cysteine.
FT                                {ECO:0000269|PubMed:11907260}.
FT   LIPID       242    242       S-palmitoyl cysteine.
FT                                {ECO:0000269|PubMed:11907260}.
FT   LIPID       243    243       S-palmitoyl cysteine.
FT                                {ECO:0000269|PubMed:11907260}.
FT   CARBOHYD    159    159       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   VARIANT     120    120       T -> M (in dbSNP:rs34215390).
FT                                {ECO:0000269|Ref.8}.
FT                                /FTId=VAR_025098.
FT   VARIANT     132    132       K -> R. {ECO:0000269|PubMed:11181065,
FT                                ECO:0000269|PubMed:8627808}.
FT                                /FTId=VAR_012490.
FT   VARIANT     137    137       P -> S. {ECO:0000269|PubMed:11181065,
FT                                ECO:0000269|PubMed:8627808}.
FT                                /FTId=VAR_012491.
FT   VARIANT     178    178       R -> H (in dbSNP:rs779114765).
FT                                {ECO:0000269|PubMed:15265795}.
FT                                /FTId=VAR_021153.
SQ   SEQUENCE   253 AA;  28295 MW;  0C8FE4CF2C3C286D CRC64;
     MGEFNEKKTT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS LLASGTYLAT
     AYILVVAGTV VMVTGVLGCC ATFKERRNLL RLYFILLLII FLLEIIAGIL AYAYYQQLNT
     ELKENLKDTM TKRYHQPGHE AVTSAVDQLQ QEFHCCGSNN SQDWRDSEWI RSQEAGGRVV
     PDSCCKTVVA LCGQRDHASN IYKVEGGCIT KLETFIQEHL RVIGAVGIGI ACVQVFGMIF
     TCCLYRSLKL EHY
//

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