(data stored in ACNUC1104 zone)

SWISSPROT: STP_MYCTO

ID   STP_MYCTO               Reviewed;         537 AA.
AC   P9WG90; L0TC78; O08222; P71879; Q7D7B2;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   08-MAY-2019, entry version 24.
DE   RecName: Full=Multidrug resistance protein Stp;
DE   AltName: Full=Spectinomycin tetracycline efflux pump;
GN   Name=stp; OrderedLocusNames=MT2395;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/JB.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H.,
RA   Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D.,
RA   Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M.,
RA   Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C.,
RA   Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. EmrB
CC       family. {ECO:0000305}.
DR   EMBL; AE000516; AAK46687.1; -; Genomic_DNA.
DR   PIR; F70705; F70705.
DR   RefSeq; WP_003899274.1; NZ_KK341227.1.
DR   EnsemblBacteria; AAK46687; AAK46687; MT2395.
DR   KEGG; mtc:MT2395; -.
DR   PATRIC; fig|83331.31.peg.2583; -.
DR   BioCyc; MTBCDC1551:GT3Z-6824-MONOMER; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; P9WG90.
DR   SWISS-2DPAGE; P9WG90.
KW   Antibiotic resistance; Cell membrane; Complete proteome; Membrane;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    537       Multidrug resistance protein Stp.
FT                                /FTId=PRO_0000428403.
FT   TRANSMEM      6     26       Helical. {ECO:0000255}.
FT   TRANSMEM     46     66       Helical. {ECO:0000255}.
FT   TRANSMEM     77     97       Helical. {ECO:0000255}.
FT   TRANSMEM    104    124       Helical. {ECO:0000255}.
FT   TRANSMEM    136    156       Helical. {ECO:0000255}.
FT   TRANSMEM    163    183       Helical. {ECO:0000255}.
FT   TRANSMEM    200    220       Helical. {ECO:0000255}.
FT   TRANSMEM    223    243       Helical. {ECO:0000255}.
FT   TRANSMEM    262    282       Helical. {ECO:0000255}.
FT   TRANSMEM    300    320       Helical. {ECO:0000255}.
FT   TRANSMEM    327    347       Helical. {ECO:0000255}.
FT   TRANSMEM    352    372       Helical. {ECO:0000255}.
FT   TRANSMEM    397    417       Helical. {ECO:0000255}.
FT   TRANSMEM    478    498       Helical. {ECO:0000255}.
SQ   SEQUENCE   537 AA;  57163 MW;  DBDAD2EBC53F9FD9 CRC64;
     MNRTQLLTLI ATGLGLFMIF LDALIVNVAL PDIQRSFAVG EDGLQWVVAS YSLGMAVFIM
     SAATLADLYG RRRWYLIGVS LFTLGSIACG LAPSIAVLTT ARGAQGLGAA AVSVTSLALV
     SAAFPEAKEK ARAIGIWTAI ASIGTTTGPT LGGLLVDQWG WRSIFYVNLP MGALVLFLTL
     CYVEESCNER ARRFDLSGQL LFIVAVGALV YAVIEGPQIG WTSVQTIVML WTAAVGCALF
     VWLERRSSNP MMDLTLFRDT SYALAIATIC TVFFAVYGML LLTTQFLQNV RGYTPSVTGL
     MILPFSAAVA IVSPLVGHLV GRIGARVPIL AGLCMLMLGL LMLIFSEHRS SALVLVGLGL
     CGSGVALCLT PITTVAMTAV PAERAGMASG IMSAQRAIGS TIGFAVLGSV LAAWLSATLE
     PHLERAVPDP VQRHVLAEII IDSANPRAHV GGIVPRRHIE HRDPVAIAEE DFIEGIRVAL
     LVATATLAVV FLAGWRWFPR DVHTAGSDLS ERLPTAMTVE CAVSHMPGAT WCRLWPA
//

If you have problems or comments...

PBIL Back to PBIL home page