(data stored in ACNUC17492 zone)

SWISSPROT: RGS1_RAT

ID   RGS1_RAT                Reviewed;         209 AA.
AC   P97844; A0A0H2UHC4; Q4KM99;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   17-FEB-2016, sequence version 3.
DT   08-MAY-2019, entry version 123.
DE   RecName: Full=Regulator of G-protein signaling 1;
DE            Short=RGS1;
GN   Name=Rgs1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 92-171.
RA   Greenwood M.T., Guo Y., Hussain S.N.A.;
RT   "The rat RGS1 gene is expressed in multiple tissues.";
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates G protein-coupled receptor signaling cascades,
CC       including signaling downstream of the N-formylpeptide
CC       chemoattractant receptors and leukotriene receptors. Inhibits B
CC       cell chemotaxis toward CXCL12 (By similarity). Inhibits signal
CC       transduction by increasing the GTPase activity of G protein alpha
CC       subunits, thereby driving them into their inactive GDP-bound form
CC       (By similarity). {ECO:0000250|UniProtKB:Q08116,
CC       ECO:0000250|UniProtKB:Q9JL25}.
CC   -!- SUBUNIT: Interacts with GNAI1 and GNAQ.
CC       {ECO:0000250|UniProtKB:Q08116}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000250|UniProtKB:Q08116}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q08116}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:Q08116}. Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q08116}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P97844-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P97844-2; Sequence=VSP_058127;
CC   -!- TISSUE SPECIFICITY: Expressed in multiple tissues.
CC       {ECO:0000305|Ref.4}.
DR   EMBL; AABR07021216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH473958; EDM09598.1; -; Genomic_DNA.
DR   EMBL; BC098681; AAH98681.1; -; mRNA.
DR   EMBL; U77698; AAB48300.1; -; mRNA.
DR   RefSeq; NP_062209.1; NM_019336.1. [P97844-2]
DR   RefSeq; XP_006250036.1; XM_006249974.3. [P97844-1]
DR   SMR; P97844; -.
DR   STRING; 10116.ENSRNOP00000005251; -.
DR   PaxDb; P97844; -.
DR   PRIDE; P97844; -.
DR   Ensembl; ENSRNOT00000005251; ENSRNOP00000005251; ENSRNOG00000003895. [P97844-1]
DR   GeneID; 54289; -.
DR   KEGG; rno:54289; -.
DR   UCSC; RGD:3561; rat. [P97844-1]
DR   CTD; 5996; -.
DR   RGD; 3561; Rgs1.
DR   eggNOG; KOG3589; Eukaryota.
DR   eggNOG; ENOG410YMJD; LUCA.
DR   GeneTree; ENSGT00940000157316; -.
DR   HOGENOM; HOG000233512; -.
DR   InParanoid; P97844; -.
DR   KO; K16449; -.
DR   OMA; KIYKAFV; -.
DR   OrthoDB; 1240467at2759; -.
DR   TreeFam; TF315837; -.
DR   Reactome; R-RNO-416476; G alpha (q) signalling events.
DR   Reactome; R-RNO-418594; G alpha (i) signalling events.
DR   PRO; PR:P97844; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000003895; Expressed in 8 organ(s), highest expression level in colon.
DR   Genevisible; P97844; RN.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0001965; F:G-protein alpha-subunit binding; IEA:Ensembl.
DR   GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0061737; P:leukotriene signaling pathway; ISS:UniProtKB.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; ISS:UniProtKB.
DR   Gene3D; 1.10.196.10; -; 2.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR030409; RGS1.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR024066; RGS_subdom1/3.
DR   PANTHER; PTHR10845:SF34; PTHR10845:SF34; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; SSF48097; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; P97844.
DR   SWISS-2DPAGE; P97844.
KW   Alternative splicing; Cell membrane; Complete proteome; Cytoplasm;
KW   GTPase activation; Membrane; Reference proteome;
KW   Signal transduction inhibitor.
FT   CHAIN         1    209       Regulator of G-protein signaling 1.
FT                                /FTId=PRO_0000204177.
FT   DOMAIN       85    200       RGS. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00171}.
FT   VAR_SEQ       1     47       Missing (in isoform 2).
FT                                /FTId=VSP_058127.
SQ   SEQUENCE   209 AA;  24096 MW;  939CCD55ADB06432 CRC64;
     MRAAAISMPR LNKMPGMFFS ASPKDSKEPS HSLLDDNKQK KRPKTFGMDM KAYLRSMIPH
     LESGMKSSKS KDILSAEEVM QWSQSLEKLL ANQMGQNVFG KFLKSEFSEE NIEFWLACED
     YKKTETDLLH NKAEHIYKAF VHSDAVKQIN IDFHTRESTA KKIKTPTPTC FDEAQKVIYA
     LMEKDSYPRF LKSNIYLNLL NDLQANTLK
//

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