(data stored in ACNUC27125 zone)


ID   ATP8_KLULA              Reviewed;          48 AA.
AC   Q00608;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   11-DEC-2019, entry version 96.
DE   RecName: Full=ATP synthase protein 8;
DE   AltName: Full=A6L;
DE   AltName: Full=F-ATPase subunit 8;
GN   Name=ATP8;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OG   Mitochondrion.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RC   STRAIN=ATCC 90735 / K8;
RX   PubMed=1657415; DOI=10.1007/bf00312772;
RA   Hardy C.M., Clark-Walker G.D.;
RT   "Nucleotide sequence of the COX1 gene in Kluyveromyces lactis mitochondrial
RT   DNA: evidence for recent horizontal transfer of a group II intron.";
RL   Curr. Genet. 20:99-114(1991).
RN   [2]
RC   STRAIN=ATCC 76492 / CBS 2359/152 / CLIB 210;
RX   PubMed=15691736; DOI=10.1016/j.femsyr.2004.09.003;
RA   Zivanovic Y., Wincker P., Vacherie B., Bolotin-Fukuhara M., Fukuhara H.;
RT   "Complete nucleotide sequence of the mitochondrial DNA from Kluyveromyces
RT   lactis.";
RL   FEMS Yeast Res. 5:315-322(2005).
CC   -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC       Complex V) produces ATP from ADP in the presence of a proton gradient
CC       across the membrane which is generated by electron transport complexes
CC       of the respiratory chain. F-type ATPases consist of two structural
CC       domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC       - containing the membrane proton channel, linked together by a central
CC       stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC       catalytic domain of F(1) is coupled via a rotary mechanism of the
CC       central stalk subunits to proton translocation. Part of the complex
CC       F(0) domain. Minor subunit located with subunit a in the membrane (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC       - and CF(0) - the membrane proton channel. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the ATPase protein 8 family. {ECO:0000305}.
DR   EMBL; X57546; CAA40770.1; -; Genomic_DNA.
DR   EMBL; AY654900; AAT64952.1; -; Genomic_DNA.
DR   PIR; S17994; S17994.
DR   RefSeq; YP_054499.1; NC_006077.1.
DR   GeneID; 2914080; -.
DR   KEGG; kla:KllafMp04; -.
DR   HOGENOM; HOG000034188; -.
DR   InParanoid; Q00608; -.
DR   KO; K02125; -.
DR   Proteomes; UP000000598; Mitochondrion.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR009230; ATP_synth_su8_fun.
DR   PANTHER; PTHR36101; PTHR36101; 1.
DR   Pfam; PF05933; Fun_ATP-synt_8; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q00608.
DR   SWISS-2DPAGE; Q00608.
KW   ATP synthesis; CF(0); Hydrogen ion transport; Ion transport; Membrane;
KW   Mitochondrion; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..48
FT                   /note="ATP synthase protein 8"
FT                   /id="PRO_0000195601"
FT   TRANSMEM        13..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   48 AA;  5711 MW;  9F5E8A929D94F8C3 CRC64;

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