(data stored in ACNUC22857 zone)

SWISSPROT: AP1B1_BOVIN

ID   AP1B1_BOVIN             Reviewed;         951 AA.
AC   Q08DS7;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   10-MAY-2017, entry version 75.
DE   RecName: Full=AP-1 complex subunit beta-1;
DE   AltName: Full=Adaptor protein complex AP-1 subunit beta-1;
DE   AltName: Full=Adaptor-related protein complex 1 subunit beta-1;
DE   AltName: Full=Beta-1-adaptin;
DE   AltName: Full=Beta-adaptin 1;
DE   AltName: Full=Clathrin assembly protein complex 1 beta large chain;
DE   AltName: Full=Golgi adaptor HA1/AP1 adaptin beta subunit;
GN   Name=AP2B1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Subunit of clathrin-associated adaptor protein complex 1
CC       that plays a role in protein sorting in the late-Golgi/trans-Golgi
CC       network (TGN) and/or endosomes. The AP complexes mediate both the
CC       recruitment of clathrin to membranes and the recognition of
CC       sorting signals within the cytosolic tails of transmembrane cargo
CC       molecules (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Adaptor protein complex 1 (AP-1) is a heterotetramer
CC       composed of two large adaptins (gamma-type subunit AP1G1 and beta-
CC       type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or
CC       AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or
CC       AP1S3). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC       membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250};
CC       Cytoplasmic side {ECO:0000250}. Golgi apparatus {ECO:0000250}.
CC       Note=Component of the coat surrounding the cytoplasmic face of
CC       coated vesicles located at the Golgi complex. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC       {ECO:0000305}.
DR   EMBL; BC123583; AAI23584.1; -; mRNA.
DR   RefSeq; NP_001068593.1; NM_001075125.1.
DR   RefSeq; XP_010814093.1; XM_010815791.2.
DR   RefSeq; XP_015323437.1; XM_015467951.1.
DR   UniGene; Bt.88309; -.
DR   ProteinModelPortal; Q08DS7; -.
DR   SMR; Q08DS7; -.
DR   STRING; 9913.ENSBTAP00000027078; -.
DR   PaxDb; Q08DS7; -.
DR   PRIDE; Q08DS7; -.
DR   GeneID; 107131160; -.
DR   GeneID; 282183; -.
DR   KEGG; bta:107131160; -.
DR   KEGG; bta:282183; -.
DR   CTD; 163; -.
DR   eggNOG; KOG1061; Eukaryota.
DR   eggNOG; COG5096; LUCA.
DR   HOGENOM; HOG000163270; -.
DR   HOVERGEN; HBG050515; -.
DR   InParanoid; Q08DS7; -.
DR   KO; K11825; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR   GO; GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008565; F:protein transporter activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 2.60.40.1150; -; 1.
DR   InterPro; IPR026739; AP_beta.
DR   InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR015151; B-adaptin_app_sub_C.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR   InterPro; IPR013037; Clathrin_b-adaptin_app_Ig-like.
DR   InterPro; IPR009028; Coatomer/calthrin_app_sub_C.
DR   InterPro; IPR013041; Coatomer/clathrin_app_Ig-like.
DR   PANTHER; PTHR11134; PTHR11134; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   Pfam; PF02883; Alpha_adaptinC2; 1.
DR   Pfam; PF09066; B2-adapt-app_C; 1.
DR   PIRSF; PIRSF002291; AP_complex_beta; 1.
DR   SMART; SM00809; Alpha_adaptinC2; 1.
DR   SMART; SM00185; ARM; 2.
DR   SMART; SM01020; B2-adapt-app_C; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49348; SSF49348; 1.
DR   SUPFAM; SSF55711; SSF55711; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q08DS7.
DR   SWISS-2DPAGE; Q08DS7.
KW   Acetylation; Complete proteome; Cytoplasmic vesicle; Golgi apparatus;
KW   Membrane; Nitration; Protein transport; Reference proteome; Transport.
FT   CHAIN         1    951       AP-1 complex subunit beta-1.
FT                                /FTId=PRO_0000283800.
FT   COMPBIAS    576    730       Pro-rich (stalk region).
FT   MOD_RES     318    318       N6-acetyllysine.
FT                                {ECO:0000250|UniProtKB:Q10567}.
FT   MOD_RES     574    574       Nitrated tyrosine.
FT                                {ECO:0000250|UniProtKB:O35643}.
SQ   SEQUENCE   951 AA;  105706 MW;  3071B89A32674CA3 CRC64;
     MTDSKYFTTN KKGEIFELKA ELNNEKKEKR KEAVKKVIAA MTVGKDVSSL FPDVVNCMQT
     DNLELKKLVY LYLMNYAKSQ PDMAIMAVNS FVKDCEDPNP LIRALAVRTM GCIRVDKITE
     YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQMVEDQG FLDSLRDLIA DSNPMVVANA
     VAALSEISES HPNSNLLDLN PQNINKLLTA LNECTEWGQI FILDCLSNYN PKDDREAQSI
     CERVTPRLSH ANSAVVLSAV KVLMKFLELL PKESDYYNML LKKLAPPLVT LLSGEPEVQY
     VALRNINLIV QKRPEILKQE IKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE
     YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIRDIFRK
     YPNKYESIIA TLCENLDSLD EPDARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV
     QLTLLTAIVK LFLKKPSETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVTAKEV
     VLSEKPLISE ETDLIEPTLL DELICHIGSL ASVYHKPPNA FVEGSHGIHR KHLPIHHGST
     DAGDSPVGTT TATNLEQPQV IPSQGDLLGD LLNLDLGPPV NVPQVSSMQM GAVDLLGGGL
     DSLLGSDLGG GIGGSPAVGQ SFIPSSVPAT FAPSPTPAVV SSGLNDLFEL STGIGMAPGG
     YVAPKAVWLP AVKAKGLEIS GTFTHRQGHI YMEMNFTNKA LQHMTDFAIQ FNKNSFGVIP
     STPLAIHTPL MPNQSIDVSL PLNTLGPVMK MEPLNNLQVA VKNNIDVFYF SCLIPLNVLF
     VEDGKMERQV FLATWKDIPN ENELQFQIKE CHLNADTVSS KLQNNNVYTI AKRNVEGQDM
     LYQSLKLTNG IWILAELRIQ PGNPNYTLSL KCRAPEVSQY IYQVYDSILK N
//

If you have problems or comments...

PBIL Back to PBIL home page